UniProtKB - Q0P670 (SPEM2_HUMAN)
Protein
Uncharacterized protein SPEM2
Gene
SPEM2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized protein SPEM2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27315, SPEM2 |
neXtProti | NX_Q0P670 |
VEuPathDBi | HostDB:ENSG00000184560.7 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 26 – 46 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 201243 |
OpenTargetsi | ENSG00000184560 |
PharmGKBi | PA142672222 |
Miscellaneous databases
Pharosi | Q0P670, Tdark |
Genetic variation databases
BioMutai | SPEM2 |
DMDMi | 261260060 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286623 | 1 – 501 | Uncharacterized protein SPEM2Add BLAST | 501 |
Proteomic databases
MassIVEi | Q0P670 |
PaxDbi | Q0P670 |
PeptideAtlasi | Q0P670 |
PRIDEi | Q0P670 |
ProteomicsDBi | 58775 |
PTM databases
iPTMneti | Q0P670 |
PhosphoSitePlusi | Q0P670 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184560, Expressed in left testis and 35 other tissues |
ExpressionAtlasi | Q0P670, baseline and differential |
Genevisiblei | Q0P670, HS |
Organism-specific databases
HPAi | ENSG00000184560, Tissue enriched (testis) |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 122 – 137 | Arg-richAdd BLAST | 16 | |
Compositional biasi | 280 – 283 | Poly-Pro | 4 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RKNT, Eukaryota |
GeneTreei | ENSGT00510000049558 |
HOGENOMi | CLU_045547_0_0_1 |
InParanoidi | Q0P670 |
OMAi | DVHIHCT |
OrthoDBi | 646751at2759 |
PhylomeDBi | Q0P670 |
TreeFami | TF337389 |
Family and domain databases
InterProi | View protein in InterPro IPR031368, SPEM1_N |
Pfami | View protein in Pfam PF15670, Spem1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q0P670-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENQLWHNTV RCCNQYQESP HDAEDILLLL LGLIVLVNIG INVATMMWHG
60 70 80 90 100
LQNALDKMID WATQKNEIQA SESPPSGPPD KAQDVHIHCI LDPVQVKMSR
110 120 130 140 150
PTQYSSFSCH HFSNHHSSSL LRCVRRRRRR HRRCRRRCCN HQQRPQNYRQ
160 170 180 190 200
IPHSHSVFRN PHRSQKMSQL HRVPFFDQED PDSYLEEEDN LPFPYPKYPR
210 220 230 240 250
RGWGGFYQRA GLPSNVGLWG HQGGILASLP PPSLYLSPEL RCMPKRVEAR
260 270 280 290 300
SELRLQSYGR HGSQSRLWGN VEAEQWASSP PPPHRLPPNP SWVPVGHSPY
310 320 330 340 350
PSVGWMLYDS WDQRRRGTEG FERPPASVSR NARPEAQGCR EHHSPQSHQQ
360 370 380 390 400
SLLGHAYGQS HRSPHPSTEP LGYSSQDPRE VRRRAADWAE ALPAWRPLTT
410 420 430 440 450
SASLTVLDEA SHQRTPAPSS VLVPHSSQPW PKVQAADPAP PPTMFVPLSR
460 470 480 490 500
NPGGNANYQV YDSLELKRQV QKSRARSSSL PPASTSTLRP SLHRSQTEKL
N
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketI3L1F6 | I3L1F6_HUMAN | Uncharacterized protein SPEM2 | SPEM2 | 125 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 409 | Missing in BC031286 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032145 | 108 | S → A. Corresponds to variant dbSNP:rs13290Ensembl. | 1 | |
Natural variantiVAR_032146 | 376 | Q → R. Corresponds to variant dbSNP:rs3892554Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113189 Genomic DNA No translation available. BC031286 mRNA No translation available. |
CCDSi | CCDS42255.1 |
RefSeqi | NP_783861.3, NM_175734.4 |
Genome annotation databases
Ensembli | ENST00000333870; ENSP00000328061; ENSG00000184560 ENST00000639609; ENSP00000492107; ENSG00000283714 |
GeneIDi | 201243 |
KEGGi | hsa:201243 |
UCSCi | uc002ggw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113189 Genomic DNA No translation available. BC031286 mRNA No translation available. |
CCDSi | CCDS42255.1 |
RefSeqi | NP_783861.3, NM_175734.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
iPTMneti | Q0P670 |
PhosphoSitePlusi | Q0P670 |
Genetic variation databases
BioMutai | SPEM2 |
DMDMi | 261260060 |
Proteomic databases
MassIVEi | Q0P670 |
PaxDbi | Q0P670 |
PeptideAtlasi | Q0P670 |
PRIDEi | Q0P670 |
ProteomicsDBi | 58775 |
Protocols and materials databases
Antibodypediai | 6127, 68 antibodies |
Genome annotation databases
Ensembli | ENST00000333870; ENSP00000328061; ENSG00000184560 ENST00000639609; ENSP00000492107; ENSG00000283714 |
GeneIDi | 201243 |
KEGGi | hsa:201243 |
UCSCi | uc002ggw.4, human |
Organism-specific databases
CTDi | 201243 |
DisGeNETi | 201243 |
GeneCardsi | SPEM2 |
HGNCi | HGNC:27315, SPEM2 |
HPAi | ENSG00000184560, Tissue enriched (testis) |
neXtProti | NX_Q0P670 |
OpenTargetsi | ENSG00000184560 |
PharmGKBi | PA142672222 |
VEuPathDBi | HostDB:ENSG00000184560.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RKNT, Eukaryota |
GeneTreei | ENSGT00510000049558 |
HOGENOMi | CLU_045547_0_0_1 |
InParanoidi | Q0P670 |
OMAi | DVHIHCT |
OrthoDBi | 646751at2759 |
PhylomeDBi | Q0P670 |
TreeFami | TF337389 |
Enzyme and pathway databases
PathwayCommonsi | Q0P670 |
Miscellaneous databases
BioGRID-ORCSi | 201243, 4 hits in 984 CRISPR screens |
GenomeRNAii | 201243 |
Pharosi | Q0P670, Tdark |
PROi | PR:Q0P670 |
RNActi | Q0P670, protein |
Gene expression databases
Bgeei | ENSG00000184560, Expressed in left testis and 35 other tissues |
ExpressionAtlasi | Q0P670, baseline and differential |
Genevisiblei | Q0P670, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031368, SPEM1_N |
Pfami | View protein in Pfam PF15670, Spem1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPEM2_HUMAN | |
Accessioni | Q0P670Primary (citable) accession number: Q0P670 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | October 13, 2009 | |
Last modified: | April 7, 2021 | |
This is version 93 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports