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UniProtKB - Q0P641 (CB080_HUMAN)

Entry version 88 (07 Apr 2021)
Sequence version 2 (20 Apr 2010)
Previous versions | rss
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Protein

Uncharacterized protein C2orf80

Gene

C2orf80

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q0P641

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C2orf80
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C2orf80
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:34352, C2orf80

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615536, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q0P641

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188674.10

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		389073

Open Targets

More...OpenTargetsi		ENSG00000188674

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162379620

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q0P641, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C2orf80

Domain mapping of disease mutations (DMDM)

More...DMDMi		294862414

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003261231 – 193Uncharacterized protein C2orf80Add BLAST193

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q0P641

PRoteomics IDEntifications database

More...PRIDEi		Q0P641

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58768

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188674, Expressed in caudate nucleus and 106 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q0P641, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q0P641, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188674, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		132959, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343171

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q0P641, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q0P641

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S0E2, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004840

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_094619_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q0P641

Identification of Orthologs from Complete Genome Data

More...OMAi		RPIYPNH

Database of Orthologous Groups

More...OrthoDBi		1331662at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q0P641

TreeFam database of animal gene trees

More...TreeFami		TF338259

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038776, C2orf80

The PANTHER Classification System

More...PANTHERi		PTHR36296, PTHR36296, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17718, DUF5563, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q0P641-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERRLIKKEM KKLLGDYIGI RLRENEFDPK GRRQLTFLDD MAHYDLAISV 
        60         70         80         90        100
ALQWLDPSED LTWLEWEELK IPLHGRPIYP NRREREAMIL SSYAGILMNS 
       110        120        130        140        150
IPIEEVFKIY GADSSADSGT IKVPRVSSLC LSLHPFAMLT APKAAAYARK 
       160        170        180        190 
QSVKSRKVTT NKNATSISAK EANATEWKSS QRFSDTQPKH KVT
Length:193
Mass (Da):22,038
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20A0E5654F8AFF1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J2L1C9J2L1_HUMAN
Uncharacterized protein C2orf80
C2orf80
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZF5H7BZF5_HUMAN
Uncharacterized protein C2orf80
C2orf80
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2S2C9J2S2_HUMAN
Uncharacterized protein C2orf80
C2orf80
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTX0C9JTX0_HUMAN
Uncharacterized protein C2orf80
C2orf80
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAS9C9JAS9_HUMAN
Uncharacterized protein C2orf80
C2orf80
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2Y3H7C2Y3_HUMAN
Uncharacterized protein C2orf80
C2orf80
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05071782R → H. Corresponds to variant dbSNP:rs11898181Ensembl.1
Natural variantiVAR_050718130C → R1 PublicationCorresponds to variant dbSNP:rs6435421Ensembl.1
Natural variantiVAR_050719152S → G. Corresponds to variant dbSNP:rs10804166Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC016697 Genomic DNA No translation available.
BC035737 mRNA Translation: AAH35737.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42809.1

NCBI Reference Sequences

More...RefSeqi		NP_001092804.1, NM_001099334.2
XP_016859565.1, XM_017004076.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341287; ENSP00000343171; ENSG00000188674

Database of genes from NCBI RefSeq genomes

More...GeneIDi		389073

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:389073

UCSC genome browser

More...UCSCi		uc002vcr.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016697 Genomic DNA No translation available.
BC035737 mRNA Translation: AAH35737.1
CCDSiCCDS42809.1
RefSeqiNP_001092804.1, NM_001099334.2
XP_016859565.1, XM_017004076.1

3D structure databases

SMRiQ0P641
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi132959, 1 interactor
STRINGi9606.ENSP00000343171

Genetic variation databases

BioMutaiC2orf80
DMDMi294862414

Proteomic databases

PaxDbiQ0P641
PRIDEiQ0P641
ProteomicsDBi58768

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52192, 31 antibodies

Genome annotation databases

EnsembliENST00000341287; ENSP00000343171; ENSG00000188674
GeneIDi389073
KEGGihsa:389073
UCSCiuc002vcr.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		389073
DisGeNETi389073

GeneCards: human genes, protein and diseases

More...GeneCardsi		C2orf80
HGNCiHGNC:34352, C2orf80
HPAiENSG00000188674, Tissue enriched (brain)
MIMi615536, gene
neXtProtiNX_Q0P641
OpenTargetsiENSG00000188674
PharmGKBiPA162379620
VEuPathDBiHostDB:ENSG00000188674.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S0E2, Eukaryota
GeneTreeiENSGT00390000004840
HOGENOMiCLU_094619_0_0_1
InParanoidiQ0P641
OMAiRPIYPNH
OrthoDBi1331662at2759
PhylomeDBiQ0P641
TreeFamiTF338259

Enzyme and pathway databases

PathwayCommonsiQ0P641

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		389073, 9 hits in 964 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		389073
PharosiQ0P641, Tdark

Protein Ontology

More...PROi		PR:Q0P641
RNActiQ0P641, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188674, Expressed in caudate nucleus and 106 other tissues
ExpressionAtlasiQ0P641, baseline and differential
GenevisibleiQ0P641, HS

Family and domain databases

InterProiView protein in InterPro
IPR038776, C2orf80
PANTHERiPTHR36296, PTHR36296, 1 hit
PfamiView protein in Pfam
PF17718, DUF5563, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCB080_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0P641
Secondary accession number(s): A6NKZ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 20, 2010
Last modified: April 7, 2021
This is version 88 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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