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Entry version 91 (16 Jan 2019)
Sequence version 1 (19 Sep 2006)
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Protein

Vacuolar protein sorting-associated protein 8 homolog

Gene

Vps8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1257 – 1309RING-type; atypicalPROSITE-ProRule annotationAdd BLAST53

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 8 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vps8
Synonyms:Kiaa0804
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2146407 Vps8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002782681 – 1427Vacuolar protein sorting-associated protein 8 homologAdd BLAST1427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphoserineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei127PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q0P5W1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q0P5W1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0P5W1

PeptideAtlas

More...
PeptideAtlasi
Q0P5W1

PRoteomics IDEntifications database

More...
PRIDEi
Q0P5W1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0P5W1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0P5W1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033653 Expressed in 234 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0P5W1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0P5W1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB5C (PubMed:25266290). Interacts with TGFBRAP1 (By similarity). Component of the putative class C core vacuole/endosome tethering (CORVET) complex; the core of which is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, associated with VPS8 and TGFBRAP1 (PubMed:25266290).By similarity1 Publication1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q0P5W1, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000111055

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q0P5W1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati193 – 234WDAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS8 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1257 – 1309RING-type; atypicalPROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

WD repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2079 Eukaryota
ENOG410XRX6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000010672

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000013171

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG071091

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0P5W1

KEGG Orthology (KO)

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KOi
K20178

Identification of Orthologs from Complete Genome Data

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OMAi
WSNVLTV

Database of Orthologous Groups

More...
OrthoDBi
22166at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314244

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025941 Vps8_central_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12816 Vps8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q0P5W1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METEPDQEHL DQNPCARTVE EELSKSFNLE ASLSKFSCLD LDKELEFRSD
60 70 80 90 100
LIDDKEFDIP QVDTPPTLES ILNETDDEDE SFVLEDPTLL NVDTIDSHSY
110 120 130 140 150
DTSSVASSDS GDRANLKRKK KLPDSFSLHG SVMRHSLLKG ISAQIVSAAD
160 170 180 190 200
KVDAGLPTAI AVSSLIAVGT SHGLALIFDQ NQALRLCLGS TSVGGQYGAI
210 220 230 240 250
SALSINNDCS RLLCGFAKGQ ITMWDLASGK LLRSITDAHP PGTAILHIKF
260 270 280 290 300
TDDPTLAICN DSGGSVFELT FKRVMGVRTC ESRCLFSGSK GEVCCIEPLH
310 320 330 340 350
SKPELKDHPI TQFSLLAMAS LTKILVIGLK PSLKVWMTFP YGRMDPSSVP
360 370 380 390 400
LLAWHFVAVN NSVNPMLAFC RGDMVHFLLV KRDESGAIHV TKQKHLHLYY
410 420 430 440 450
DLINFTWINS RTVVLLDSVE KLHVIDRQTQ EELETMEISE VQLVYNSSHF
460 470 480 490 500
KSLATGGNVS QALALVGEKA CYQSISSYGG QIFYLGTKSV YVMMLRSWRE
510 520 530 540 550
RMDHLLKQDC LTEALALAWS FHEGKAKAVV GLSGDVSKRK AVVADRMVEI
560 570 580 590 600
LFHYADRALK KCPDQGKIQV MEQHFQDTVP VIVDYCLLLQ RKDLLFGQMY
610 620 630 640 650
DKLSENSVAK GVFLECLEPY ILSDKLVGIT PQVMKDLIVH FQDKKLLENV
660 670 680 690 700
EALIVHMDIT SLDIQQVVLM CWENRLYDAM VYVYNRGMNE FISPMEKLFK
710 720 730 740 750
VIAPPLNAGK TLTDEQVVMG NKLLVYISCC LAGRAYPLGD IPEDLVPLVK
760 770 780 790 800
NQVFEFLIRL HSVEASSEEE VYPYVRTLLH FDTREFLNVL ALTFEDFKND
810 820 830 840 850
KQAVEYQQRI VDILLKVMVE NSDFTPSQVG CLFTFLARQL AKPDNTLFVN
860 870 880 890 900
RTLFDQVLEF LCSPDDDSRH SERQQVLLEL LQAGGIVQFE ESRLIRMAEK
910 920 930 940 950
AEFYQICEFM YEREHQYDKI IDCYLHDPLR EEEVFNYIHN ILSIPGHSAE
960 970 980 990 1000
EKQSVWQKAM NHMEELVSLK PCKAAELVAT HFSEQIEVVI GQLQNQLLLF
1010 1020 1030 1040 1050
KFLRSLLDPR EGVHVNQELL QIPPHITEQF IELLCQFSPD QVIQTLQVLE
1060 1070 1080 1090 1100
CYRLEETIQI TQKYQLHEVT AYLLEKKGDA HGAFLLLLER LQSRLQEMTR
1110 1120 1130 1140 1150
QDENTKEDIL LKGVEDTMVE TIALCQRNSQ NLNQQQREAL WFPLLEAMMT
1160 1170 1180 1190 1200
PQKLSSSAAA PHPHCEALKS LTMQVLNSMA AFIALPSILQ RILQDPIYGK
1210 1220 1230 1240 1250
GKLGEIQGLI LGMLDTFNYE QTLLETTASL LNQDLHWSLC NLRASVSRGL
1260 1270 1280 1290 1300
NPKQDYCSIC LQQYKRRQEM ADEIIVFSCG HLYHSFCLQS KECTLEVEGQ
1310 1320 1330 1340 1350
TRWACHKCSS SNKAGKLSEN PSENKKGRIT SSQVKMSPSY HQSKGDPPAR
1360 1370 1380 1390 1400
KANSEPVLDP QQMQAFDQLC RLYRGSSRLA LLTELSQNRG GDSCRPFAGP
1410 1420
QSGPAFNSVF QKENFQLQLA PPPVAED
Length:1,427
Mass (Da):161,146
Last modified:September 19, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E88538003B36B72
GO
Isoform 2 (identifier: Q0P5W1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1278-1292: SCGHLYHSFCLQSKE → RFLYWVTGASPIQPK
     1293-1427: Missing.

Note: No experimental confirmation available.
Show »
Length:1,292
Mass (Da):146,393
Checksum:iD47F5716E4CE0631
GO
Isoform 3 (identifier: Q0P5W1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: F → FGK
     965-994: Missing.

Note: No experimental confirmation available.
Show »
Length:1,399
Mass (Da):158,068
Checksum:i6C337962F31AB989
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUP0D3YUP0_MOUSE
Vacuolar protein sorting-associated...
Vps8
1,429Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WI64F8WI64_MOUSE
Vacuolar protein sorting-associated...
Vps8
1,399Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZLN8F6ZLN8_MOUSE
Vacuolar protein sorting-associated...
Vps8
964Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2G2D3Z2G2_MOUSE
Vacuolar protein sorting-associated...
Vps8
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7A250F7A250_MOUSE
Vacuolar protein sorting-associated...
Vps8
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P780A0A338P780_MOUSE
Vacuolar protein sorting-associated...
Vps8
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH32214 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC26237 differs from that shown. Reason: Frameshift at position 631.Curated
The sequence BAC65657 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti591R → G in BAC26237 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023252178F → FGK in isoform 3. 1 Publication1
Alternative sequenceiVSP_023253965 – 994Missing in isoform 3. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_0232541278 – 1292SCGHL…LQSKE → RFLYWVTGASPIQPK in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0232551293 – 1427Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK122375 mRNA Translation: BAC65657.1 Different initiation.
AK029007 mRNA Translation: BAC26237.1 Frameshift.
AK141678 mRNA Translation: BAE24795.1
BC032214 mRNA Translation: AAH32214.1 Different initiation.
BC055323 mRNA Translation: AAH55323.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS70700.1 [Q0P5W1-3]
CCDS70701.1 [Q0P5W1-1]

NCBI Reference Sequences

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RefSeqi
NP_001272822.1, NM_001285893.1 [Q0P5W1-1]
NP_001272823.1, NM_001285894.1 [Q0P5W1-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.235683

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000096191; ENSMUSP00000093905; ENSMUSG00000033653 [Q0P5W1-2]
ENSMUST00000117598; ENSMUSP00000112937; ENSMUSG00000033653 [Q0P5W1-1]
ENSMUST00000118923; ENSMUSP00000112636; ENSMUSG00000033653 [Q0P5W1-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
209018

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:209018

UCSC genome browser

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UCSCi
uc007yrj.2 mouse [Q0P5W1-1]
uc012adi.2 mouse [Q0P5W1-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122375 mRNA Translation: BAC65657.1 Different initiation.
AK029007 mRNA Translation: BAC26237.1 Frameshift.
AK141678 mRNA Translation: BAE24795.1
BC032214 mRNA Translation: AAH32214.1 Different initiation.
BC055323 mRNA Translation: AAH55323.1
CCDSiCCDS70700.1 [Q0P5W1-3]
CCDS70701.1 [Q0P5W1-1]
RefSeqiNP_001272822.1, NM_001285893.1 [Q0P5W1-1]
NP_001272823.1, NM_001285894.1 [Q0P5W1-3]
UniGeneiMm.235683

3D structure databases

ProteinModelPortaliQ0P5W1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0P5W1, 1 interactor
STRINGi10090.ENSMUSP00000111055

PTM databases

iPTMnetiQ0P5W1
PhosphoSitePlusiQ0P5W1

Proteomic databases

jPOSTiQ0P5W1
MaxQBiQ0P5W1
PaxDbiQ0P5W1
PeptideAtlasiQ0P5W1
PRIDEiQ0P5W1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096191; ENSMUSP00000093905; ENSMUSG00000033653 [Q0P5W1-2]
ENSMUST00000117598; ENSMUSP00000112937; ENSMUSG00000033653 [Q0P5W1-1]
ENSMUST00000118923; ENSMUSP00000112636; ENSMUSG00000033653 [Q0P5W1-3]
GeneIDi209018
KEGGimmu:209018
UCSCiuc007yrj.2 mouse [Q0P5W1-1]
uc012adi.2 mouse [Q0P5W1-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23355
MGIiMGI:2146407 Vps8

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG2079 Eukaryota
ENOG410XRX6 LUCA
GeneTreeiENSGT00390000010672
HOGENOMiHOG000013171
HOVERGENiHBG071091
InParanoidiQ0P5W1
KOiK20178
OMAiWSNVLTV
OrthoDBi22166at2759
TreeFamiTF314244

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Vps8 mouse

Protein Ontology

More...
PROi
PR:Q0P5W1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033653 Expressed in 234 organ(s), highest expression level in brain
ExpressionAtlasiQ0P5W1 baseline and differential
GenevisibleiQ0P5W1 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR025941 Vps8_central_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12816 Vps8, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0P5W1
Secondary accession number(s): Q3UR93, Q80TR5, Q8K280
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: September 19, 2006
Last modified: January 16, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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