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Protein
Submitted name:

WW domain-containing oxidoreductase

Gene

WWOX

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-1251985 Nuclear signaling by ERBB4
R-BTA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-BTA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Names & Taxonomyi

Protein namesi
Submitted name:
WW domain-containing oxidoreductaseImported
Gene namesi
Name:WWOXImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:36977 WWOX

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSBTAG00000015894 Expressed in 9 organ(s), highest expression level in prefrontal cortex

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000032547

Structurei

3D structure databases

SMRiQ0P5N4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 49WWInterPro annotationAdd BLAST34
Domaini57 – 90WWInterPro annotationAdd BLAST34

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
COG5021 LUCA
GeneTreeiENSGT00760000119068
HOVERGENiHBG078800
KOiK19329
OMAiAATSIYC
OrthoDBiEOG091G0EI5
TreeFamiTF105428

Family and domain databases

CDDicd00201 WW, 2 hits
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PF00397 WW, 2 hits
PRINTSiPR00081 GDHRDH
SMARTiView protein in SMART
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q0P5N4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALRYAGLD DTDSEDELPP GWEQRTTKDG WVYYANHTEE KTQWEHPKTG
60 70 80 90 100
KRKRIAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK
110 120 130 140 150
PTTRQRYDGS TTAMEILQGR DLSGKVVVVT GANSGIGFET AKSFALHGAH
160 170 180 190 200
VILACRNMTR ANEAVSRILG EWHKAKVEAM TLDLALLRSV QHFAQAFKAK
210 220 230 240 250
NVSLHVLVCN AAVFGLPWTL TKDGLETTFQ VNHLGHFYLV QLLQDVLCRS
260 270 280 290 300
APARVVVVSS ESHRFTDIND SSGKLDFSRL SPSKNDYWAM LAYNRSKLCN
310 320 330 340 350
ILFSNELHRR LSPRGVTSNA VHPGNMMYSA LHRGWWVYTL LFTLARPFTK
360 370 380 390 400
SMQQGAATTV YCAVAPELEG LGGMYFNSCC RCLPSAEAQS EDSARALWAL
410
SERLLQGVPG GPPS
Length:414
Mass (Da):46,191
Last modified:September 19, 2006 - v1
Checksum:iFDEE208DC9E8C103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02046067 Genomic DNA No translation available.
DAAA02046068 Genomic DNA No translation available.
DAAA02046069 Genomic DNA No translation available.
DAAA02046070 Genomic DNA No translation available.
DAAA02046071 Genomic DNA No translation available.
DAAA02046072 Genomic DNA No translation available.
DAAA02046073 Genomic DNA No translation available.
DAAA02046074 Genomic DNA No translation available.
DAAA02046075 Genomic DNA No translation available.
DAAA02046076 Genomic DNA No translation available.
BC119823 mRNA Translation: AAI19824.1
FJ978047 mRNA Translation: ADC84386.1
RefSeqiNP_001071560.1, NM_001078092.1
UniGeneiBt.104291
Bt.88210

Genome annotation databases

EnsembliENSBTAT00000032617; ENSBTAP00000032547; ENSBTAG00000015894
GeneIDi618792
KEGGibta:618792

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02046067 Genomic DNA No translation available.
DAAA02046068 Genomic DNA No translation available.
DAAA02046069 Genomic DNA No translation available.
DAAA02046070 Genomic DNA No translation available.
DAAA02046071 Genomic DNA No translation available.
DAAA02046072 Genomic DNA No translation available.
DAAA02046073 Genomic DNA No translation available.
DAAA02046074 Genomic DNA No translation available.
DAAA02046075 Genomic DNA No translation available.
DAAA02046076 Genomic DNA No translation available.
BC119823 mRNA Translation: AAI19824.1
FJ978047 mRNA Translation: ADC84386.1
RefSeqiNP_001071560.1, NM_001078092.1
UniGeneiBt.104291
Bt.88210

3D structure databases

SMRiQ0P5N4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000032547

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000032617; ENSBTAP00000032547; ENSBTAG00000015894
GeneIDi618792
KEGGibta:618792

Organism-specific databases

CTDi51741
VGNCiVGNC:36977 WWOX

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
COG5021 LUCA
GeneTreeiENSGT00760000119068
HOVERGENiHBG078800
KOiK19329
OMAiAATSIYC
OrthoDBiEOG091G0EI5
TreeFamiTF105428

Enzyme and pathway databases

ReactomeiR-BTA-1251985 Nuclear signaling by ERBB4
R-BTA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-BTA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Gene expression databases

BgeeiENSBTAG00000015894 Expressed in 9 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd00201 WW, 2 hits
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PF00397 WW, 2 hits
PRINTSiPR00081 GDHRDH
SMARTiView protein in SMART
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ0P5N4_BOVIN
AccessioniPrimary (citable) accession number: Q0P5N4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 19, 2006
Last sequence update: September 19, 2006
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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