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UniProtKB - Q0P5M9 (MFS10_BOVIN)
Protein
Major facilitator superfamily domain-containing protein 10
Gene
MFSD10
Organism
Bos taurus (Bovine)
Status
Functioni
Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump (By similarity).
By similarityGO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Major facilitator superfamily domain-containing protein 10Alternative name(s): Tetracycline transporter-like protein |
Gene namesi | Name:MFSD10 Synonyms:TETRAN |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000021130 |
VGNCi | VGNC:31432, MFSD10 |
Subcellular locationi
Nucleus
- Nucleus inner membrane By similarity; Multi-pass membrane protein Sequence analysis
Nucleus
- nuclear inner membrane Source: UniProtKB
Plasma Membrane
- brush border membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 125 – 145 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 179 – 199 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 278 – 298 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 311 – 328 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 343 – 363 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 365 – 385 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 422 – 442 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324657 | 1 – 456 | Major facilitator superfamily domain-containing protein 10Add BLAST | 456 |
Proteomic databases
PaxDbi | Q0P5M9 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000021130, Expressed in pituitary gland and 93 other tissues |
ExpressionAtlasi | Q0P5M9, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily.Sequence analysis
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2615, Eukaryota |
GeneTreei | ENSGT00830000128422 |
HOGENOMi | CLU_001265_10_2_1 |
InParanoidi | Q0P5M9 |
OrthoDBi | 787769at2759 |
TreeFami | TF314512 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q0P5M9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGCGAGGSCT PRPPIRQQQA PETRVVAVVF LGLLLDLLAF TLLLPLLPGL
60 70 80 90 100
LESHGRAHDP LYGSWQRGVD WFAAAIGMPA EKRYNSVLFG GLIGSVFSLL
110 120 130 140 150
QFLSAPLTGA LSDCLGRRPG MLLSLAGVAT SYAVWAASKS FAAFLASRVI
160 170 180 190 200
GGISKGNVSL CTAIVADLGS PSARSKGMAV IGVAFSLGFT LGPTLGAFLP
210 220 230 240 250
SETVPWLALL FAVSDLLFIW CFLPETLPPE KRAPSVTLGF RAAADLLSPL
260 270 280 290 300
ALLRFSAVAR GPDPPTGVRL GSLRGLGLVY FLYLFLFSGL EFTLSFLVHQ
310 320 330 340 350
RFRFSRVEQG KMFFFIGLTM ATIQGAYARR IRPGREIAAV KQAILLLIPA
360 370 380 390 400
SLFVGWGHTL PILGLGLLLY SWAAAVVVPC LSSVVAGYGS PGQKGTVMGT
410 420 430 440 450
LRSLGALARA VGPVVAASAY WLAGARVCYT VCAALFLLPF SILRTLSPPA
RTLKAE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1LMJ2 | A0A3Q1LMJ2_BOVIN | Major facilitator superfamily domai... | MFSD10 | 440 | Annotation score: | ||
A0A3Q1MB25 | A0A3Q1MB25_BOVIN | Major facilitator superfamily domai... | MFSD10 | 460 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC119845 mRNA Translation: AAI19846.1 |
RefSeqi | NP_001068772.1, NM_001075304.1 XP_010804632.1, XM_010806330.2 |
Genome annotation databases
Ensembli | ENSBTAT00000028155; ENSBTAP00000028155; ENSBTAG00000021130 |
GeneIDi | 507194 |
KEGGi | bta:507194 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC119845 mRNA Translation: AAI19846.1 |
RefSeqi | NP_001068772.1, NM_001075304.1 XP_010804632.1, XM_010806330.2 |
3D structure databases
SMRi | Q0P5M9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000028155 |
Proteomic databases
PaxDbi | Q0P5M9 |
Genome annotation databases
Ensembli | ENSBTAT00000028155; ENSBTAP00000028155; ENSBTAG00000021130 |
GeneIDi | 507194 |
KEGGi | bta:507194 |
Organism-specific databases
CTDi | 10227 |
VEuPathDBi | HostDB:ENSBTAG00000021130 |
VGNCi | VGNC:31432, MFSD10 |
Phylogenomic databases
eggNOGi | KOG2615, Eukaryota |
GeneTreei | ENSGT00830000128422 |
HOGENOMi | CLU_001265_10_2_1 |
InParanoidi | Q0P5M9 |
OrthoDBi | 787769at2759 |
TreeFami | TF314512 |
Gene expression databases
Bgeei | ENSBTAG00000021130, Expressed in pituitary gland and 93 other tissues |
ExpressionAtlasi | Q0P5M9, baseline and differential |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MFS10_BOVIN | |
Accessioni | Q0P5M9Primary (citable) accession number: Q0P5M9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | September 19, 2006 | |
Last modified: | February 23, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families