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Protein

Homeobox protein MSX-2

Gene

MSX2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi142 – 201HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processOsteogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MSX-2
Gene namesi
Name:MSX2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Organism-specific databases

VGNCiVGNC:31712 MSX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002840761 – 267Homeobox protein MSX-2Add BLAST267

Proteomic databases

PaxDbiQ0P5C3

Expressioni

Gene expression databases

BgeeiENSBTAG00000013873 Expressed in 6 organ(s), highest expression level in prefrontal cortex

Interactioni

Subunit structurei

Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018417

Structurei

3D structure databases

ProteinModelPortaliQ0P5C3
SMRiQ0P5C3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Msh homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0492 Eukaryota
ENOG410YT2J LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231922
HOVERGENiHBG005205
InParanoidiQ0P5C3
KOiK09341
OMAiPLGYSMY
OrthoDBiEOG091G0P1V
TreeFamiTF350699

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0P5C3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPSKGNDL FSSDEEGPAM VAGPGPGPGG AEGAAEERRV KVSSLPFSVE
60 70 80 90 100
ALMSDKKPPK ETSPRPAESA SAGATLRPLL LPGHGVREAH SPGPLVKPFE
110 120 130 140 150
TASVKSENSE DGAAWMQEPG RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT
160 170 180 190 200
TSQLLALERK FRQKQYLSIA ERAEFSSSLN LTETQVKIWF QNRRAKAKRL
210 220 230 240 250
QEAELEKLKM AAKPMLPSGF SLPFPINSPL QAASLYGASY PFHRPVLPIP
260
PVGLYATPVG YGMYHLS
Length:267
Mass (Da):29,027
Last modified:September 19, 2006 - v1
Checksum:iDB4F56EDFCEF1DDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120248 mRNA Translation: AAI20249.1
RefSeqiNP_001073082.1, NM_001079614.2
UniGeneiBt.102117

Genome annotation databases

EnsembliENSBTAT00000018417; ENSBTAP00000018417; ENSBTAG00000013873
GeneIDi540230
KEGGibta:540230

Similar proteinsi

Entry informationi

Entry nameiMSX2_BOVIN
AccessioniPrimary (citable) accession number: Q0P5C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: September 19, 2006
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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