UniProtKB - Q0P543 (GIPR_MOUSE)
Protein
Gastric inhibitory polypeptide receptor
Gene
Gipr
Organism
Mus musculus (Mouse)
Status
Functioni
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity
GO - Molecular functioni
- gastric inhibitory peptide receptor activity Source: MGI
- G protein-coupled peptide receptor activity Source: GO_Central
- peptide hormone binding Source: MGI
- signaling receptor activity Source: MGI
GO - Biological processi
- cell surface receptor signaling pathway Source: InterPro
- desensitization of G protein-coupled receptor signaling pathway Source: MGI
- endocrine pancreas development Source: MGI
- neuropeptide signaling pathway Source: MGI
- positive regulation of cAMP-mediated signaling Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of insulin secretion Source: MGI
- response to axon injury Source: Ensembl
- response to calcium ion Source: MGI
- response to fatty acid Source: Ensembl
- response to glucose Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-418555 G alpha (s) signalling events R-MMU-420092 Glucagon-type ligand receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Gastric inhibitory polypeptide receptorShort name: GIP-R Alternative name(s): Glucose-dependent insulinotropic polypeptide receptor |
Gene namesi | Name:Gipr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1352753 Gipr |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 134 | ExtracellularSequence analysisAdd BLAST | 116 | |
Transmembranei | 135 – 155 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 156 – 222 | CytoplasmicSequence analysisAdd BLAST | 67 | |
Transmembranei | 223 – 243 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 244 – 255 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 256 – 276 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 277 – 297 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 298 – 318 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 319 – 337 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 338 – 358 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 359 – 370 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 371 – 391 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 392 – 460 | ExtracellularSequence analysisAdd BLAST | 69 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000306251 | 19 – 460 | Gastric inhibitory polypeptide receptorAdd BLAST | 442 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 66 | By similarity | ||
Disulfide bondi | 57 ↔ 99 | By similarity | ||
Glycosylationi | 58 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 80 ↔ 114 | By similarity |
Post-translational modificationi
N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q0P543 |
PRIDEi | Q0P543 |
PTM databases
PhosphoSitePlusi | Q0P543 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030406 Expressed in 21 organ(s), highest expression level in testis |
ExpressionAtlasi | Q0P543 baseline and differential |
Genevisiblei | Q0P543 MM |
Interactioni
Subunit structurei
May form homodimers and heterodimers with GLP1R.By similarity
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000092384 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000161988 |
HOGENOMi | HOG000008250 |
HOVERGENi | HBG008318 |
InParanoidi | Q0P543 |
KOi | K04580 |
OMAi | PAGLACN |
OrthoDBi | 651627at2759 |
PhylomeDBi | Q0P543 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR001749 GPCR_2_GIP_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR01129 GIPRECEPTOR PR00249 GPCRSECRETIN |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q0P543-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MPLRLLLLLL WLWGLQWAET DSEGQTTTGE LYQRWEHYGQ ECQKMLETTE
60 70 80 90 100
PPSGLACNGS FDMYACWNYT AANTTARVSC PWYLPWFRQV SAGFVFRQCG
110 120 130 140 150
SDGQWGSWRD HTQCENPEKN GAFQDQTLIL ERLQIMYTVG YSLSLTTLLL
160 170 180 190 200
ALLILSLFRR LHCTRNYIHM NLFTSFMLRA AAILTRDQLL PPLGPYTGDQ
210 220 230 240 250
APTPWNQALA ACRTAQIMTQ YCVGANYTWL LVEGVYLHHL LVIVGRSEKG
260 270 280 290 300
HFRCYLLLGW GAPALFVIPW VIVRYLRENT QCWERNEVKA IWWIIRTPIL
310 320 330 340 350
ITILINFLIF IRILGILVSK LRTRQMRCPD YRLRLARSTL TLVPLLGVHE
360 370 380 390 400
VVFAPVTEEQ VEGSLRFAKL AFEIFLSSFQ GFLVSVLYCF INKEVQSEIR
410 420 430 440 450
QGWRHRRLRL SLQEQRPRPH QELAPRAVPL SSACREAAVG NALPSGMLHV
460
PGDEVLESYC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RP73 | A0A0U1RP73_MOUSE | Gastric inhibitory polypeptide rece... | Gipr | 140 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 122 | A → V in AAO85080 (PubMed:12679517).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028433 | 208 – 230 | ALAAC…NYTWL → VLHRLLPGGTKTFPIYFRTF PHH in isoform 2. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_028434 | 231 – 460 | Missing in isoform 2. 1 PublicationAdd BLAST | 230 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC145199 Genomic DNA No translation available. BC120671 mRNA Translation: AAI20672.1 BC120673 mRNA Translation: AAI20674.1 AY255568 mRNA Translation: AAO85080.1 |
CCDSi | CCDS39795.1 [Q0P543-1] |
RefSeqi | NP_001074284.1, NM_001080815.1 [Q0P543-1] |
UniGenei | Mm.333633 |
Genome annotation databases
Ensembli | ENSMUST00000094790; ENSMUSP00000092384; ENSMUSG00000030406 [Q0P543-1] |
GeneIDi | 381853 |
KEGGi | mmu:381853 |
UCSCi | uc009fkw.1 mouse [Q0P543-1] uc009fkx.1 mouse [Q0P543-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC145199 Genomic DNA No translation available. BC120671 mRNA Translation: AAI20672.1 BC120673 mRNA Translation: AAI20674.1 AY255568 mRNA Translation: AAO85080.1 |
CCDSi | CCDS39795.1 [Q0P543-1] |
RefSeqi | NP_001074284.1, NM_001080815.1 [Q0P543-1] |
UniGenei | Mm.333633 |
3D structure databases
ProteinModelPortali | Q0P543 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000092384 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | Q0P543 |
Proteomic databases
PaxDbi | Q0P543 |
PRIDEi | Q0P543 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000094790; ENSMUSP00000092384; ENSMUSG00000030406 [Q0P543-1] |
GeneIDi | 381853 |
KEGGi | mmu:381853 |
UCSCi | uc009fkw.1 mouse [Q0P543-1] uc009fkx.1 mouse [Q0P543-2] |
Organism-specific databases
CTDi | 2696 |
MGIi | MGI:1352753 Gipr |
Phylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000161988 |
HOGENOMi | HOG000008250 |
HOVERGENi | HBG008318 |
InParanoidi | Q0P543 |
KOi | K04580 |
OMAi | PAGLACN |
OrthoDBi | 651627at2759 |
PhylomeDBi | Q0P543 |
TreeFami | TF315710 |
Enzyme and pathway databases
Reactomei | R-MMU-418555 G alpha (s) signalling events R-MMU-420092 Glucagon-type ligand receptors |
Miscellaneous databases
PROi | PR:Q0P543 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030406 Expressed in 21 organ(s), highest expression level in testis |
ExpressionAtlasi | Q0P543 baseline and differential |
Genevisiblei | Q0P543 MM |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR001749 GPCR_2_GIP_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR01129 GIPRECEPTOR PR00249 GPCRSECRETIN |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | GIPR_MOUSE | |
Accessioni | Q0P543Primary (citable) accession number: Q0P543 Secondary accession number(s): Q80UB4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | February 13, 2019 | |
This is version 96 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries