UniProtKB - Q0P4H0 (ADAT2_XENTR)
Protein
tRNA-specific adenosine deaminase 2
Gene
adat2
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.By similarity
Catalytic activityi
- EC:3.5.4.33Curated
Cofactori
Zn2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 54 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 56 | Proton donorBy similarity | 1 | |
Metal bindingi | 90 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 93 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- tRNA-specific adenosine-34 deaminase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- tRNA wobble adenosine to inosine editing Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | tRNA processing |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA-specific adenosine deaminase 2 (EC:3.5.4.33Curated)Alternative name(s): Deaminase domain-containing protein 1 tRNA-specific adenosine-34 deaminase subunit ADAT2 |
Gene namesi | Name:adat2 Synonyms:deadc1 |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-963029, adat2 |
Subcellular locationi
Other locations
- tRNA-specific adenosine-34 deaminase complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287657 | 1 – 170 | tRNA-specific adenosine deaminase 2Add BLAST | 170 |
Proteomic databases
PaxDbi | Q0P4H0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 128 | CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST | 126 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1018, Eukaryota |
InParanoidi | Q0P4H0 |
OrthoDBi | 1616309at2759 |
Family and domain databases
HAMAPi | MF_00972, tRNA_aden_deaminase, 1 hit |
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR016193, Cytidine_deaminase-like IPR028883, tRNA_aden_deaminase |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q0P4H0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEEIQNWMH KAFQMAQDAL NNGEVPVGCL MVYDNQVVGK GRNEVNETKN
60 70 80 90 100
ATRHAEMVAI DQVLDWCEKN SKKSRDVFEN IVLYVTVEPC IMCAGALRLL
110 120 130 140 150
KIPLVVYGCR NERFGGCGSV LNVAGDNIPD TGTEFKYIGG YQAEKAVELL
160 170
KTFYKQENPN APRSKVRKKE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A7D9N0E8 | A0A7D9N0E8_XENTR | tRNA-specific adenosine deaminase 2 | adat2 | 175 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC122084 mRNA Translation: AAI22085.1 |
RefSeqi | NP_001072562.1, NM_001079094.1 |
Genome annotation databases
GeneIDi | 780017 |
KEGGi | xtr:780017 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC122084 mRNA Translation: AAI22085.1 |
RefSeqi | NP_001072562.1, NM_001079094.1 |
3D structure databases
SMRi | Q0P4H0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000021557 |
Proteomic databases
PaxDbi | Q0P4H0 |
Genome annotation databases
GeneIDi | 780017 |
KEGGi | xtr:780017 |
Organism-specific databases
CTDi | 134637 |
Xenbasei | XB-GENE-963029, adat2 |
Phylogenomic databases
eggNOGi | KOG1018, Eukaryota |
InParanoidi | Q0P4H0 |
OrthoDBi | 1616309at2759 |
Family and domain databases
HAMAPi | MF_00972, tRNA_aden_deaminase, 1 hit |
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR016193, Cytidine_deaminase-like IPR028883, tRNA_aden_deaminase |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAT2_XENTR | |
Accessioni | Q0P4H0Primary (citable) accession number: Q0P4H0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | September 19, 2006 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families