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Protein

Mdm2-binding protein

Gene

mtbp

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth arrest, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Mdm2-binding protein
Gene namesi
Name:mtbp
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-990920 mtbp

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003237481 – 867Mdm2-binding proteinAdd BLAST867

Proteomic databases

PaxDbiQ0P4G8
PRIDEiQ0P4G8

Structurei

3D structure databases

SMRiQ0P4G8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MTBP family.Curated

Phylogenomic databases

eggNOGiENOG410IIA4 Eukaryota
ENOG410YVAG LUCA
HOGENOMiHOG000113675
HOVERGENiHBG108152
InParanoidiQ0P4G8

Family and domain databases

InterProiView protein in InterPro
IPR039061 MTBP
IPR029418 MTBP_C
IPR029420 MTBP_central
IPR029421 MTBP_N
PANTHERiPTHR14382 PTHR14382, 1 hit
PfamiView protein in Pfam
PF14920 MTBP_C, 1 hit
PF14919 MTBP_mid, 1 hit
PF14918 MTBP_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q0P4G8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERFVLCIHW ERRAESGAEQ HRVPQGLAYA QDIYTQLKEY STKYTSTFPA
60 70 80 90 100
CSLTGNPGTR KWFFALQSLY GSFQFCSSDW DDLCPAVTTE DNEEPVQTAL
110 120 130 140 150
DECLEALQFP DGEDDNSRDS ISQTNLFEEA AELLHQLSDK LPAPGRALVD
160 170 180 190 200
VLLFTPEAPK LKDCLSAIGA IKHLKEWHSA KITIVSKDCK GWQKIAKFLS
210 220 230 240 250
ANVVESACPK ELIDSHELWR GNIEISERKF TSEVEFPEFC LRSVSDDKFP
260 270 280 290 300
YFEHNGDDKN KAVLLPEVFH YYGTSLEYVQ MVALSEIPSY FVSDSVFELS
310 320 330 340 350
ITRNALQGKS KLMLDQLCSL TDKVGAIFML SCNVCSLPNP PALQRSSKKW
360 370 380 390 400
REYMSRKPKD IKVPGVELKG EYCSYYFLIQ GKGSGFCKAT LLHSASQISG
410 420 430 440 450
AASLVLLHQR LNNYQPGNMA EGTSEILDSV PHFRGEQIAV RERILARAQA
460 470 480 490 500
LAVNEYLKRH EALPHPSVSH VNNLRTLLAV TRERVIGDCE SRLDGVSYKN
510 520 530 540 550
LQNITVSTPT VSESEAMISN PADWPERNVL QNLENFEKVK QRLRASILSS
560 570 580 590 600
SAEQLLGRKD GLKEGMTLLD AKELLKYFTP QGIAVGELQP LQVQRGDNAF
610 620 630 640 650
LLTPKLTPKK LKGLPFEKAA ECHYHGLEYC LDNRKALDRD VAFSELQSRL
660 670 680 690 700
IRYETQTTCT RECCPVPFAL SPLPSPAVLS EPGSVPDGES IQTELRGEPL
710 720 730 740 750
LLKRRSRDLD GLYASKRLAK SGSSDSLVSL ASEGSGHQPP TRATRLRPER
760 770 780 790 800
AASSTSAVQP PSARVQMAPS VPAQSKQSTH PDLEQKESRS QKHNRMLKEV
810 820 830 840 850
VSKTLQKYGI GVEHPCYAAC NQRLFDISKF FLKDLKTSRG LLDEMKKAAS
860
NNAKQVIQWE LDKLKKK
Length:867
Mass (Da):97,059
Last modified:March 18, 2008 - v2
Checksum:iC0B9694A05530FD5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7BPE7F7BPE7_XENTR
Mdm2-binding protein
mtbp
870Annotation score:

Sequence cautioni

The sequence AAI22087 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122086 mRNA Translation: AAI22087.1 Different initiation.
BC155673 mRNA Translation: AAI55674.1
RefSeqiNP_001107690.1, NM_001114218.1
UniGeneiStr.16675

Genome annotation databases

GeneIDi779505
KEGGixtr:779505

Similar proteinsi

Entry informationi

Entry nameiMTBP_XENTR
AccessioniPrimary (citable) accession number: Q0P4G8
Secondary accession number(s): A9JRI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 12, 2018
This is version 40 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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