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Protein

Zinc metalloproteinase-disintegrin-like bothrojarin-1

Gene
N/A
Organism
Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The hemorrhagic metalloproteinase-disintegrin-like bothrojarin-1 is a potent inhibitor of collagen-induced platelet aggregation by blockage of alpha-2/beta-1 (ITGA2/ITGB1) integrin. It does not present any fibrinogen-clotting activity (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7Calcium; via carbonyl oxygenBy similarity1
Metal bindingi10CalciumBy similarity1
Metal bindingi12Calcium; via carbonyl oxygenBy similarity1
Metal bindingi14CalciumBy similarity1
Metal bindingi17CalciumBy similarity1
Metal bindingi20CalciumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Hydrolase, Metalloprotease, Platelet aggregation inhibiting toxin, Protease, Toxin
LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase-disintegrin-like bothrojarin-1 (EC:3.4.24.-)
Alternative name(s):
Snake venom metalloproteinase
Short name:
SVMP
OrganismiBothrops jararaca (Jararaca) (Bothrops jajaraca)
Taxonomic identifieri8724 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeBothrops

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000329983‹1 – ›166Zinc metalloproteinase-disintegrin-like bothrojarin-1Add BLAST›166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi8 ↔ 37PROSITE-ProRule annotation
Disulfide bondi19 ↔ 32PROSITE-ProRule annotation
Disulfide bondi21 ↔ 27PROSITE-ProRule annotation
Disulfide bondi31 ↔ 54PROSITE-ProRule annotation
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi45 ↔ 51PROSITE-ProRule annotation
Disulfide bondi50 ↔ 76PROSITE-ProRule annotation
Disulfide bondi63 ↔ 83PROSITE-ProRule annotation
Disulfide bondi70 ↔ 102PROSITE-ProRule annotation
Disulfide bondi95 ↔ 107PROSITE-ProRule annotation
Disulfide bondi114 ↔ 164PROSITE-ProRule annotation
Disulfide bondi142 ↔ 152PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ0NZY0
SMRiQ0NZY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 91DisintegrinPROSITE-ProRule annotationAdd BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi69 – 71D/ECD-tripeptide3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG101729

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q0NZY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DIVSPPVCGN YFVEVGEECD CGRPGKCQNP CCNATTCKLT PGSQCADGLC
60 70 80 90 100
CDQCRFKGAG TECRAARSEC DIAESCTGQS PECPTDDFQR NGQPCLNNQG
110 120 130 140 150
YCYNGNCPIL DHQCHNLFGA GATVAPDACF NFNRRGQGIY YCRKQNGVTI
160
PCARKDIKCG RLFCVQ
Length:166
Mass (Da):17,951
Last modified:September 19, 2006 - v1
Checksum:i40885BC7ECA3069F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1661

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ375436 mRNA Translation: ABD34829.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ375436 mRNA Translation: ABD34829.1

3D structure databases

ProteinModelPortaliQ0NZY0
SMRiQ0NZY0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG101729

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVM3B1_BOTJA
AccessioniPrimary (citable) accession number: Q0NZY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 19, 2006
Last modified: November 22, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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