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Protein

Poly(A) polymerase catalytic subunit

Gene

VARV-VD21-UVic-047

Organism
Variola virus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.UniRule annotation

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei202UniRule annotation1
Active sitei204UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processmRNA processingUniRule annotation, TranscriptionUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunitUniRule annotation (EC:2.7.7.19UniRule annotation)
Alternative name(s):
Poly(A) polymerase large subunitUniRule annotation
Gene namesi
Name:VARV-VD21-UVic-047Imported
Synonyms:E1LImported
ORF Names:VARV_AFG70_vlt4_045Imported, VARV_BEN68_59_045Imported, VARV_BSH74_nur_045Imported, VARV_BSH74_shz_045Imported, VARV_BSH74_sol_045Imported, VARV_BSH75_banu_045Imported, VARV_CHN48_horn_045Imported, VARV_CNG70_227_045Imported, VARV_CNG70_46_045Imported, VARV_ETH72_16_045Imported, VARV_ETH72_17_045Imported, VARV_GER58_hdlg_045Imported, VARV_GUI69_005_045Imported, VARV_IND53_mad_045Imported, VARV_IND53_ndel_045Imported, VARV_IND64_vel4_045Imported, VARV_IND64_vel5_045Imported, VARV_IRN72_tbrz_045Imported, VARV_JAP51_hrpr_045Imported, VARV_JAP51_stwl_045Imported, VARV_KOR47_lee_045Imported, VARV_KUW67_1629_045Imported, VARV_NEP73_175_045Imported, VARV_NIG69_001_045Imported, VARV_PAK69_lah_045Imported, VARV_SLN68_258_045Imported, VARV_SOM77_1252_045Imported, VARV_SOM77_1605_045Imported, VARV_SOM77_ali_045Imported, VARV_SUD47_jub_045Imported, VARV_SUD47_rum_045Imported, VARV_SUM70_222_045Imported, VARV_SUM70_228_045Imported, VARV_SYR72_119_045Imported, VARV_TAN65_kem_045Imported, VARV_UNK46_hind_045Imported, VARV_UNK47_hig_045Imported, VARV_UNK52_but_045Imported, VARV_YUG72_164_045Imported
OrganismiVariola virusImported
Taxonomic identifieri10255 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000098225 Componenti: Genome
  • UP000117241 Componenti: Genome
  • UP000145752 Componenti: Genome
  • UP000170050 Componenti: Genome
  • UP000156539 Componenti: Genome
  • UP000170428 Componenti: Genome
  • UP000133301 Componenti: Genome
  • UP000127036 Componenti: Genome
  • UP000122860 Componenti: Genome
  • UP000107112 Componenti: Genome
  • UP000126850 Componenti: Genome
  • UP000129347 Componenti: Genome
  • UP000127760 Componenti: Genome
  • UP000136898 Componenti: Genome
  • UP000141018 Componenti: Genome
  • UP000116035 Componenti: Genome
  • UP000112452 Componenti: Genome
  • UP000130170 Componenti: Genome
  • UP000120193 Componenti: Genome
  • UP000165444 Componenti: Genome
  • UP000166432 Componenti: Genome
  • UP000158565 Componenti: Genome
  • UP000105724 Componenti: Genome
  • UP000118036 Componenti: Genome
  • UP000140295 Componenti: Genome
  • UP000113219 Componenti: Genome
  • UP000181005 Componenti: Genome
  • UP000117332 Componenti: Genome
  • UP000112873 Componenti: Genome
  • UP000098436 Componenti: Genome
  • UP000181075 Componenti: Genome
  • UP000160505 Componenti: Genome
  • UP000134328 Componenti: Genome
  • UP000168855 Componenti: Genome
  • UP000142290 Componenti: Genome
  • UP000154290 Componenti: Genome
  • UP000134690 Componenti: Genome
  • UP000100387 Componenti: Genome
  • UP000136147 Componenti: Genome

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 117Pox_polyA_pol_NInterPro annotationAdd BLAST103
Domaini132 – 279Pox_polyA_polInterPro annotationAdd BLAST148
Domaini282 – 478Pox_polyA_pol_CInterPro annotationAdd BLAST197

Sequence similaritiesi

Belongs to the poxviridae poly(A) polymerase catalytic subunit family.UniRule annotation

Family and domain databases

Gene3Di1.20.1270.320, 1 hit
3.30.460.60, 1 hit
InterProiView protein in InterPro
IPR037265 PolyA_pol_cat_sf
IPR024231 Pox_polyA_pol_nucTrfase
IPR038419 Pox_polyA_pol_nucTrfase_sf
IPR004976 Poxviridae_polyA_pol_cat
IPR024397 Poxvirus_polyA_pol_cat_C
IPR024398 Poxvirus_polyA_pol_cat_N
IPR038337 Poxvirus_polyA_pol_cat_N_sf
PfamiView protein in Pfam
PF03296 Pox_polyA_pol, 1 hit
PF12629 Pox_polyA_pol_C, 1 hit
PF12630 Pox_polyA_pol_N, 1 hit
PIRSFiPIRSF015693 VAC-48L_nuct, 2 hits
SUPFAMiSSF160957 SSF160957, 1 hit

Sequencei

Sequence statusi: Complete.

Q0N5A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRNPDHNTL PNITLKIIET YLGRLPSVNE YHMLKLQTRN IQKITVFNKD
60 70 80 90 100
IFVSLVKKNK KRFFSDVDTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL
110 120 130 140 150
QSVLVTTYTD ILGVLTIKAP NVISSKISYN VTSMEELARD MLNSMNVAVI
160 170 180 190 200
DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN KSCICYGSYS LYLINPNIRY
210 220 230 240 250
GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY MVIKDENDNH
260 270 280 290 300
IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK
310 320 330 340 350
DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRVVTVTTKD
360 370 380 390 400
YFSFKKCLVY LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF
410 420 430 440 450
SNTILLSDKG KVHEISARGL CAHILLYQML TSGAYKQCLS DLLNSMMNRD
460 470
KIPIYSHTER DKKHGRHGFI NIEKDIIVF
Length:479
Mass (Da):55,553
Last modified:September 19, 2006 - v1
Checksum:i63EC3937D25A9149
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ441416 Genomic DNA Translation: ABF22805.1
DQ441420 Genomic DNA Translation: ABF23618.1
DQ441421 Genomic DNA Translation: ABF23814.1
DQ441422 Genomic DNA Translation: ABF24011.1
DQ441423 Genomic DNA Translation: ABF24208.1
DQ441424 Genomic DNA Translation: ABF24409.1
DQ441425 Genomic DNA Translation: ABF24611.1
DQ441426 Genomic DNA Translation: ABF24813.1
DQ441427 Genomic DNA Translation: ABF25014.1
DQ441428 Genomic DNA Translation: ABF25214.1
DQ441430 Genomic DNA Translation: ABF25618.1
DQ441431 Genomic DNA Translation: ABF25819.1
DQ441432 Genomic DNA Translation: ABF26021.1
DQ441433 Genomic DNA Translation: ABF26223.1
DQ441434 Genomic DNA Translation: ABF26425.1
DQ441437 Genomic DNA Translation: ABF27031.1
DQ441438 Genomic DNA Translation: ABF27232.1
DQ441439 Genomic DNA Translation: ABF27431.1
DQ441440 Genomic DNA Translation: ABF27630.1
DQ441441 Genomic DNA Translation: ABF27830.1
DQ441442 Genomic DNA Translation: ABF28030.1
DQ441443 Genomic DNA Translation: ABF28229.1
DQ441445 Genomic DNA Translation: ABF28629.1
DQ441446 Genomic DNA Translation: ABF28827.1
DQ441447 Genomic DNA Translation: ABF29031.1
DQ441448 Genomic DNA Translation: ABF29234.1
DQ437580 Genomic DNA Translation: ABG43210.1
DQ437581 Genomic DNA Translation: ABG43413.1
DQ437582 Genomic DNA Translation: ABG43614.1
DQ437583 Genomic DNA Translation: ABG43818.1
DQ437584 Genomic DNA Translation: ABG44021.1
DQ437585 Genomic DNA Translation: ABG44223.1
DQ437586 Genomic DNA Translation: ABG44427.1
DQ437587 Genomic DNA Translation: ABG44629.1
DQ437588 Genomic DNA Translation: ABG44832.1
DQ437589 Genomic DNA Translation: ABG45034.1
DQ437590 Genomic DNA Translation: ABG45237.1
DQ437591 Genomic DNA Translation: ABG45439.1
DQ437592 Genomic DNA Translation: ABG45641.1
KY358055 Genomic DNA Translation: APR62780.1
BK010317 Genomic DNA Translation: DAA80547.1

Similar proteinsi

Entry informationi

Entry nameiQ0N5A5_VARV
AccessioniPrimary (citable) accession number: Q0N5A5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 19, 2006
Last sequence update: September 19, 2006
Last modified: March 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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