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Protein

Alpha/kappa-conotoxin-like fe14.1

Gene
N/A
Organism
Conus ferrugineus (Cone snail)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Highly inhibits both nicotinic acetylcholine receptors (neuronal (alpha-3/beta-4) and neuromuscular (alpha-1/beta-1/epsilon/delta) subtypes) and the voltage-gated potassium channel Kv1.6/KCNA6 subtype.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha/kappa-conotoxin-like fe14.1
OrganismiConus ferrugineus (Cone snail)
Taxonomic identifieri379542 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusStrategoconus

Organism-specific databases

ConoServeri1186 Fe14.1 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000026001825 – 39By similarityAdd BLAST15
PeptideiPRO_000026001940 – 64Alpha/kappa-conotoxin-like fe14.1Add BLAST25
PropeptideiPRO_000026002065 – 76By similarityAdd BLAST12

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 61By similarity
Disulfide bondi50 ↔ 63By similarity
Modified residuei64Arginine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliQ0N4U4
SMRiQ0N4U4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XIV (C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin J superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0N4U4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSVRSVTCC CLLWMMLSVQ LVTPGSPGTA QLSGHRTARS PGSTICKMAC
60 70
RTGNGHKYPF CNCRGKRDVV SSSMAV
Length:76
Mass (Da):8,108
Last modified:September 19, 2006 - v1
Checksum:i4BCDAB0D64EBB0E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ447644 mRNA Translation: ABE27010.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ447644 mRNA Translation: ABE27010.1

3D structure databases

ProteinModelPortaliQ0N4U4
SMRiQ0N4U4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1186 Fe14.1 precursor

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCJE1_CONFR
AccessioniPrimary (citable) accession number: Q0N4U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: September 19, 2006
Last modified: September 12, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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