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UniProtKB - Q0MVN8 (QOR_PIG)
Protein
Quinone oxidoreductase
Gene
CRYZ
Organism
Sus scrofa (Pig)
Status
Functioni
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).
By similarityCatalytic activityi
- EC:1.6.5.5
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 53 | NADPBy similarity | 1 | |
Binding sitei | 181 | NADP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 200 | NADPBy similarity | 1 | |
Binding sitei | 229 | NADPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 158 – 161 | NADPBy similarity | 4 | |
Nucleotide bindingi | 246 – 249 | NADPBy similarity | 4 | |
Nucleotide bindingi | 269 – 271 | NADPBy similarity | 3 |
GO - Molecular functioni
- mRNA 3'-UTR binding Source: UniProtKB
- NADPH:quinone reductase activity Source: UniProtKB
- NADPH binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- xenobiotic catabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase, RNA-binding |
Ligand | NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Quinone oxidoreductase (EC:1.6.5.5)Alternative name(s): NADPH:quinone reductase Zeta-crystallin |
Gene namesi | Name:CRYZ |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000251735 | 2 – 329 | Quinone oxidoreductaseAdd BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 23 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 248 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q0MVN8 |
PeptideAtlasi | Q0MVN8 |
PRIDEi | Q0MVN8 |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 9823.ENSSSCP00000004089 |
Family & Domainsi
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1198, Eukaryota |
InParanoidi | Q0MVN8 |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR002364, Quin_OxRdtase/zeta-crystal_CS |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01162, QOR_ZETA_CRYSTAL, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q0MVN8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATGQKLMSA IRVFKFGGPE VMKLQSDVAI PIPKDNQVLI KVHACGVNPV
60 70 80 90 100
DTYIRSGTHN MKPLLPYTPG LDVAGIVEAV GEHVSSFKKG DRVFTVSTLS
110 120 130 140 150
GGYAEYALAA DDTVYMLPEK LDFKQGAAIG IPYFTACLAL LHSACVKAGE
160 170 180 190 200
IVLIHGASGG VGIAACQIAR AYGLKVLGTA GTEEGQNIVL QNGAHEVFNH
210 220 230 240 250
REVNYIDKIK KSVGEKGIDV IIEMLANVNL SNDLNLLSHG GRVIIVGSRG
260 270 280 290 300
PIEINPRDTM TKGSSIKGVA LYSSTKEEFQ QLAAALQAGM EVGWLRPVIG
310 320
PVYPLEKAAQ AHEDIIHSRG ATGKMILLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ841573 mRNA Translation: ABH10011.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ841573 mRNA Translation: ABH10011.1 |
3D structure databases
AlphaFoldDBi | Q0MVN8 |
SMRi | Q0MVN8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000004089 |
Proteomic databases
PaxDbi | Q0MVN8 |
PeptideAtlasi | Q0MVN8 |
PRIDEi | Q0MVN8 |
Phylogenomic databases
eggNOGi | KOG1198, Eukaryota |
InParanoidi | Q0MVN8 |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR002364, Quin_OxRdtase/zeta-crystal_CS |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01162, QOR_ZETA_CRYSTAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QOR_PIG | |
Accessioni | Q0MVN8Primary (citable) accession number: Q0MVN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | September 19, 2006 | |
Last modified: | May 25, 2022 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families