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UniProtKB - Q0MQ92 (NDUA2_GORGO)
Protein
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Gene
NDUFA2
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Functioni
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
By similarityGO - Biological processi
- mitochondrial respiratory chain complex I assembly Source: UniProtKB
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2Alternative name(s): Complex I-B8 Short name: CI-B8 NADH-ubiquinone oxidoreductase B8 subunit |
Gene namesi | Name:NDUFA2 |
Organismi | Gorilla gorilla gorilla (Western lowland gorilla) |
Taxonomic identifieri | 9595 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla › |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity
Mitochondrion
- mitochondrial respiratory chain complex I Source: UniProtKB
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000251799 | 2 – 99 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2Add BLAST | 98 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Disulfide bondi | 24 ↔ 58 | Redox-activeBy similarity | ||
Modified residuei | 64 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 64 | N6-succinyllysine; alternateBy similarity | 1 |
Keywords - PTMi
Acetylation, Disulfide bondExpressioni
Gene expression databases
Bgeei | ENSGGOG00000013369, Expressed in heart and 7 other tissues |
Interactioni
Subunit structurei
Complex I is composed of 45 different subunits.
By similarityProtein-protein interaction databases
STRINGi | 9593.ENSGGOP00000013040 |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I NDUFA2 subunit family.Curated
Phylogenomic databases
eggNOGi | KOG3446, Eukaryota |
HOGENOMi | CLU_110897_0_0_1 |
InParanoidi | Q0MQ92 |
OMAi | QHYVTLK |
OrthoDBi | 1633416at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR016464, NADH_Ub_cplx-1_asu_su-2 IPR007741, Ribosome/NADH_DH IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR12878, PTHR12878, 1 hit |
Pfami | View protein in Pfam PF05047, L51_S25_CI-B8, 1 hit |
PIRSFi | PIRSF005822, NDUA2, 1 hit |
SMARTi | View protein in SMART SM00916, L51_S25_CI-B8, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q0MQ92-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAASRGI GAKLGLREIR IHLCQRSPGS RGVRDFIEKR YVELKKANSD
60 70 80 90
LPILIRECSD VQPKLWARYA FGQETNVPLN NFSADQVTRA LENVLSGKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ885742 mRNA Translation: ABH12251.1 |
RefSeqi | NP_001266516.1, NM_001279587.1 |
Genome annotation databases
GeneIDi | 101147705 |
KEGGi | ggo:101147705 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ885742 mRNA Translation: ABH12251.1 |
RefSeqi | NP_001266516.1, NM_001279587.1 |
3D structure databases
SMRi | Q0MQ92 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9593.ENSGGOP00000013040 |
Genome annotation databases
GeneIDi | 101147705 |
KEGGi | ggo:101147705 |
Organism-specific databases
CTDi | 4695 |
Phylogenomic databases
eggNOGi | KOG3446, Eukaryota |
HOGENOMi | CLU_110897_0_0_1 |
InParanoidi | Q0MQ92 |
OMAi | QHYVTLK |
OrthoDBi | 1633416at2759 |
Gene expression databases
Bgeei | ENSGGOG00000013369, Expressed in heart and 7 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR016464, NADH_Ub_cplx-1_asu_su-2 IPR007741, Ribosome/NADH_DH IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR12878, PTHR12878, 1 hit |
Pfami | View protein in Pfam PF05047, L51_S25_CI-B8, 1 hit |
PIRSFi | PIRSF005822, NDUA2, 1 hit |
SMARTi | View protein in SMART SM00916, L51_S25_CI-B8, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NDUA2_GORGO | |
Accessioni | Q0MQ92Primary (citable) accession number: Q0MQ92 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | September 29, 2021 | |
This is version 84 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families