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Entry version 79 (26 Feb 2020)
Sequence version 3 (11 Jan 2011)
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Protein

Piezo-type mechanosensitive ion channel component 1

Gene

Piezo1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.By similarity

Miscellaneous

Piezo comes from the Greek 'piesi' meaning pressure.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Piezo-type mechanosensitive ion channel component 1
Alternative name(s):
Membrane protein induced by beta-amyloid treatment
Short name:
Mib
Protein FAM38A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Piezo1
Synonyms:Fam38a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
1308822 Piezo1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21
Transmembranei568 – 588HelicalSequence analysisAdd BLAST21
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21
Transmembranei678 – 698HelicalSequence analysisAdd BLAST21
Transmembranei809 – 829HelicalSequence analysisAdd BLAST21
Transmembranei838 – 858HelicalSequence analysisAdd BLAST21
Transmembranei912 – 932HelicalSequence analysisAdd BLAST21
Transmembranei973 – 993HelicalSequence analysisAdd BLAST21
Transmembranei997 – 1014HelicalSequence analysisAdd BLAST18
Transmembranei1029 – 1049HelicalSequence analysisAdd BLAST21
Transmembranei1146 – 1166HelicalSequence analysisAdd BLAST21
Transmembranei1170 – 1190HelicalSequence analysisAdd BLAST21
Transmembranei1198 – 1218HelicalSequence analysisAdd BLAST21
Transmembranei1223 – 1243HelicalSequence analysisAdd BLAST21
Transmembranei1263 – 1283HelicalSequence analysisAdd BLAST21
Transmembranei1687 – 1707HelicalSequence analysisAdd BLAST21
Transmembranei1721 – 1741HelicalSequence analysisAdd BLAST21
Transmembranei1966 – 1986HelicalSequence analysisAdd BLAST21
Transmembranei2007 – 2027HelicalSequence analysisAdd BLAST21
Transmembranei2036 – 2056HelicalSequence analysisAdd BLAST21
Transmembranei2065 – 2085HelicalSequence analysisAdd BLAST21
Transmembranei2133 – 2153HelicalSequence analysisAdd BLAST21
Transmembranei2181 – 2201HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2202 – 2445ExtracellularBy similarityAdd BLAST244
Transmembranei2446 – 2466HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003057821 – 2535Piezo-type mechanosensitive ion channel component 1Add BLAST2535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei749PhosphoserineCombined sources1
Modified residuei1372PhosphoserineCombined sources1
Modified residuei1377PhosphoserineBy similarity1
Modified residuei1614PhosphoserineBy similarity1
Modified residuei1618PhosphoserineBy similarity1
Modified residuei1633PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2425 ↔ 2429By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q0KL00

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0KL00

PRoteomics IDEntifications database

More...
PRIDEi
Q0KL00

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0KL00

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0KL00

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Moderate expression in lung and kidney. Very weak expression in heart, spleen and liver.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By APP.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

Interacts with PKD2.

Interacts with STOML3.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000055134

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1325 – 1356Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 71Leu-richAdd BLAST66

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1893 Eukaryota
ENOG410YVF6 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0KL00

KEGG Orthology (KO)

More...
KOi
K22128

Database of Orthologous Groups

More...
OrthoDBi
13738at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0KL00

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13167 PTHR13167, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q0KL00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPHVLGAGL YWLLLPCTLL AASLLRFNAL SLVYLLFLLL LPWLPGPSRH
60 70 80 90 100
SIPGHTGRLL RALLCLSLLF LVAHVAFQIC LHTMPRLNQL LGQNCNLWAN
110 120 130 140 150
VSQHIGVTRL DLKDIFNTTR LVAPDLGVLV ASSLCLGLCG RLTRKARQSQ
160 170 180 190 200
RTQELEEDDI DAAPAAGLQG APTLATKRRL WLAPRFRITA HWLLVTSGRM
210 220 230 240 250
LVIVLLALAG IAHPSAFSSV YLMVFLAICT WWSCHFPLSS LGFNTLCVMV
260 270 280 290 300
SCFGAGHLVC LYCYQTPFVQ SVLLPGSLWA RLFGLKNFVD IPNCSSPNVL
310 320 330 340 350
VLNTKHAWPI YVSPGILLLL YYTATSLLKL RKGRFSELRK EIPREDEEHE
360 370 380 390 400
LELDQLEPEP QARGTTQGAT PTTTGPDIDN CTVHVLTSQS PVRQRPVRPR
410 420 430 440 450
LAELKEMSPL HGLGHLILDQ SYVCALIAMM VWSIMYHSWL TFVLLLWACL
460 470 480 490 500
IWTVRSRHQL AMLCSPCILL YGLTLCCLRY VWAMELPELP TTLGPVSLHQ
510 520 530 540 550
LGLEHTRYPC LDLGAMLLYL LTFWLLLRQF VKEKLLKKRK APSTLLEVTV
560 570 580 590 600
SDTEPTQTQT LLRSLGELVT GIYVKYWIYV CAGMFIVVSF AGRLVVYKIV
610 620 630 640 650
YMFLFLLCLT LFQVYYTLWR KLLRVFWWLV VAYTMLVLIA VYTFQFQDFP
660 670 680 690 700
TYWRNLTGFT DEQLGDLGLE QFSVSELFSS ILIPGFFLLA CILQLHYFHR
710 720 730 740 750
PFMQLTDLEH VPPPGTRRLR WAHRQDTVSE APLLQHQEEE EVFRDDGQSM
760 770 780 790 800
DGPHQTTQVP EGTASKWGLV ADRLLDLASS FSAVLTRIQV FVRCLLELHV
810 820 830 840 850
FKLVALYTVW VALKEVSVMN LLLVVLWAFA LPYPRFRPMA SCLSTVWTCI
860 870 880 890 900
IIVCKMLYQL KIVNPHEYSS NCTEPFPNNT NLQPLEISQS LLYRGPVDPA
910 920 930 940 950
NWFGVRKGYP NLGYIQNHLQ ILLLLVFEAV VYRRQEHYRR QHQQAPLPAQ
960 970 980 990 1000
ALCADGTRQR LDQDLLSCLK YFINFFFYKF GLEICFLMAV NVIGQRMNFM
1010 1020 1030 1040 1050
VILHGCWLVA ILTRRRREAI ARLWPNYCLF LTLFLLYQYL LCLGMPPALC
1060 1070 1080 1090 1100
IDYPWRWSQA IPMNSALIKW LYLPDFFRAP NSTNLISDFL LLLCASQQWQ
1110 1120 1130 1140 1150
VFSAEQTEEW QRMAGVNTDH LEPLRGEPNP IPNFIHCRSY LDMLKVAVFR
1160 1170 1180 1190 1200
YLFWLVLVVV FVTGATRISI FGLGYLLACF YLLLFGTTLL QKDTRAQLVL
1210 1220 1230 1240 1250
WDCLILYNVT VIISKNMLSL LSCVFVEQMQ SNFCWVIQLF SLVCTVKGYY
1260 1270 1280 1290 1300
DPKEMKTRDR DCLLPVEEAG IIWDSICFFF LLLQRRVFLS HYFLHVSADL
1310 1320 1330 1340 1350
KATALQASRG FALYNAANIK NINFHRQTEE RSLAQLKRQM KRIRAKQEKY
1360 1370 1380 1390 1400
RQSQASRGQL QSTDPQEPGP DSPGGSSPPR TQWWRPWQDH ATVIHSGDYF
1410 1420 1430 1440 1450
LFESDSEEEE EALPEDPRPA AQSAFQMAYQ AWVTNAQTVL RQRREQARRD
1460 1470 1480 1490 1500
RAEQLASGGD LSPEVELVDV PENEMAGHSH VMQRVLSTMQ FLWVLGQATV
1510 1520 1530 1540 1550
DGLTRWLRTF TKDHRTMSDV LCAERYLLTQ ELLRGGEVHR GVLDQLYVSE
1560 1570 1580 1590 1600
DEIALSGPVE NRDGPSTASS GLGAEEPLSS MTDDTGSPLS TGYNTRSGSE
1610 1620 1630 1640 1650
EIITDTGGLQ AGTSLHGSQE LLANARTRMR TASELLLDRR LRIPELEEAE
1660 1670 1680 1690 1700
QFEAQQGRTL RLLRAMYQCV AAHSELLCYF IIILNHMVTA SAASLVLPVL
1710 1720 1730 1740 1750
VFLWAMLTIP RPSKRFWMTA IVFTEVMVVT KYLFQFGFFP WNSYIVLRRY
1760 1770 1780 1790 1800
ENKPYFPPRI LGLEKTDSYI KYDLVQLMAL FFHRSQLLCY GLWDHEEDGV
1810 1820 1830 1840 1850
PKDHCRSSEK DQEAEEESEA KLESQPETGT GHPEEPVLTG TPKDHIQGKG
1860 1870 1880 1890 1900
SVRSKDEIQD PPEDLKPQHR RHISIRFRRR KETQGPKGAA VVEAEHEEGE
1910 1920 1930 1940 1950
EGREAAGRKR LRRPREGLKI REKMKAAGRR LQSFCLSLAQ SFYQPLRRFF
1960 1970 1980 1990 2000
HDILHTKYRA ATDVYALMFL ADIVDIVVII FGFWAFGKHS AATDIASSLS
2010 2020 2030 2040 2050
DDQVPQAFLF MLLVQFGTMV IDRALYLRKT VLGNLAFQVV LVVAIHLWMF
2060 2070 2080 2090 2100
FILPAVTERM FRQNAVAQLW YFVKCIYFAL SAYQIRCGYP TRILGNFLTK
2110 2120 2130 2140 2150
KYNHLNLFLF QGFRLVPFLV ELRAVMDWVW TDTTLSLSNW MCVEDIYANI
2160 2170 2180 2190 2200
FIIKCSRETE KKYPQPKGQK KKKIVKYGMG GLIILFLIAI IWFPLLFMSL
2210 2220 2230 2240 2250
IRSVVGVVNQ PIDVTVTLKL GGYEPLFTMS AQQPSIVPFT PEDYEELSQQ
2260 2270 2280 2290 2300
FDPYPLAMQF ISQYSPEDIV TAQIEGSSGA LWRISPPSRA QMKHELYNGT
2310 2320 2330 2340 2350
ADITLRFTWN FQRDLAKGGS VEYTNEKHTL ELAPNSTARR QLAQLLEGRP
2360 2370 2380 2390 2400
DQSVVIPHLF PKYIRAPNGP EANPVKQLQP DEEEDYLGVR IQLRREQVGT
2410 2420 2430 2440 2450
GTSGEQAGTK ASDFLEWWVI ELQDCQAECN LLPMVIFSDK VSPPSLGFLA
2460 2470 2480 2490 2500
GYGIVGLYVS IVLVVGKFVR GFFSDISHSI MFEELPCVDR ILKLCQDIFL
2510 2520 2530
VRETRELELE EELYAKLIFL YRSPETMIKW TREKE
Length:2,535
Mass (Da):290,315
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D02F8B2C2EB65AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JWS3A0A0G2JWS3_RAT
Piezo-type mechanosensitive ion cha...
Piezo1
2,535Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR03113655 Genomic DNA No translation available.
AABR03113740 Genomic DNA No translation available.
AABR03114647 Genomic DNA No translation available.
AB161229 mRNA Translation: BAF03564.1

NCBI Reference Sequences

More...
RefSeqi
NP_001070668.2, NM_001077200.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
361430

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:361430

UCSC genome browser

More...
UCSCi
RGD:1308822 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113655 Genomic DNA No translation available.
AABR03113740 Genomic DNA No translation available.
AABR03114647 Genomic DNA No translation available.
AB161229 mRNA Translation: BAF03564.1
RefSeqiNP_001070668.2, NM_001077200.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055134

PTM databases

iPTMnetiQ0KL00
PhosphoSitePlusiQ0KL00

Proteomic databases

jPOSTiQ0KL00
PaxDbiQ0KL00
PRIDEiQ0KL00

Genome annotation databases

GeneIDi361430
KEGGirno:361430
UCSCiRGD:1308822 rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9780
RGDi1308822 Piezo1

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA
InParanoidiQ0KL00
KOiK22128
OrthoDBi13738at2759
PhylomeDBiQ0KL00

Miscellaneous databases

Protein Ontology

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PROi
PR:Q0KL00

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIEZ1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0KL00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 11, 2011
Last modified: February 26, 2020
This is version 79 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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