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Entry version 115 (07 Oct 2020)
Sequence version 1 (03 Oct 2006)
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Protein

Dystrophin, isoform D

Gene

Dys

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. May play a role in anchoring the cytoskeleton to the plasma membrane.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1463 – 1510ZZ-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q0KI50

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dystrophin, isoform D2 Publications
Alternative name(s):
Protein detachedBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dys
Synonyms:det
ORF Names:CG34157
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0260003, Dys

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies that have reduced expression of all isoforms (due to transgenic RNA interference targeting the common C-terminal region) exhibit severe muscle degeneration in larvae and adult flies. Muscles were either ruptured, absent, or the fibers were detached from their attachment sites at tendon cells. These are necrotic, not apoptotic processes.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003654541 – 1854Dystrophin, isoform DAdd BLAST1854

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1564Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q0KI50

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0KI50

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During embryogenesis and in third instar larvae, expression is seen in pericardial cells of the dorsal vessel and in the ventral nerve cord. Expression is absent from both the embryonic and larval musculature.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0260003, Expressed in spermathecum and 59 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0KI50, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0KI50, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the dystrophin associated protein complex (DAPC).

Interacts with Dg, via the Dg WW domain binding sites.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
67322, 74 interactors

Protein interaction database and analysis system

More...
IntActi
Q0KI50, 5 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0KI50

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati936 – 1069Spectrin 1Sequence analysisAdd BLAST134
Repeati1072 – 1176Spectrin 2Sequence analysisAdd BLAST105
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1206 – 1239WWPROSITE-ProRule annotationAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 37Gln-richSequence analysisAdd BLAST27
Compositional biasi196 – 289Gln-richSequence analysisAdd BLAST94
Compositional biasi627 – 732Ser-richSequence analysisAdd BLAST106
Compositional biasi778 – 814Gln-richSequence analysisAdd BLAST37
Compositional biasi1832 – 1848Thr-richSequence analysisAdd BLAST17

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1463 – 1510ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166230

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_236807_0_0_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR018159, Spectrin/alpha-actinin
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00569, ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00150, SPEC, 3 hits
SM00456, WW, 1 hit
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 2 hits
SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50020, WW_DOMAIN_2, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform D1 Publication (identifier: Q0KI50-1) [UniParc]FASTAAdd to basket
Also known as: Dp2051 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTTITAKIA QRQQQHQQHQ QQQLQHQQQQ QQQQQHQPTS SMNGFRITGY
60 70 80 90 100
PAAATPPARS NPIYAKPNAH ELDLHISESL LYPGSTTQQQ QALQSSPGPP
110 120 130 140 150
PQLTSMLPSS GLPGAAQPIA LKGNNPFLNS PSPTEAAPGV PTGLSSAQPA
160 170 180 190 200
TSASSGNYEM PEYAEPSRLR GLKQRPHSIA VGGSPAQSSF VDYNAQQQQR
210 220 230 240 250
LLQLSRQQQQ LRNAVTAAAS TANGGDKETL YAALFQQYRQ SPTNGQPAPP
260 270 280 290 300
VPLHRKPAAA PVVPRRSQST PRPPLQQQQQ QQQAGINGQI NGNGNQRPRS
310 320 330 340 350
LDRFNGGLQS EAPPIPLRRF PNGNGNNNNG TLSRQKSPKK SSSADNMLMS
360 370 380 390 400
PAGSQVNTMR HSISFHGGQE TENGSKAEQT RPMSYAAPAP DQAYLEHQLR
410 420 430 440 450
AYSEQLRTIT ESVRKYSEQA KLLSELKRQQ QLAKQSQTNL NLLTPTTCNN
460 470 480 490 500
STGSNGNNNF QPNMISPEIV SKSLASLSTS QANEAQTPSN QLRLFLDNIR
510 520 530 540 550
SSMRQEYQQH MPDDVLKPTS TLKRNGTDSL VTSNTAAKPE VEATPTPSDQ
560 570 580 590 600
LRQFLDAIRA NKIPESVDKP KMTSSQTLDS FISKPLQMPD VTSGTPGGGV
610 620 630 640 650
VGGQAASGGV AVNGQTNGIP TRRRPKSSII PSSSNGKLEQ REHSLVTSES
660 670 680 690 700
FHQISDNLRL MSEDLQALSP SKAIPSSASS NSLKSLAANG GSSLTTELRV
710 720 730 740 750
ITSSPYSTSP KLQQMVMSKS NSSLGSVTTP SSATTTPSTA PMITDFNEIL
760 770 780 790 800
DSFQAMADKY KSKGSYDYLR KCSEALRQHS LQLKLQQQHQ AHQQQQLPAH
810 820 830 840 850
QQQQHQQQQQ QQIQNGFASD DNSSSCSTTP GSIREAVQNL LLQPRNGFQI
860 870 880 890 900
LDDRMRLFID IIDSQDRLSQ DLQSEIETHR VVYDRLDGTG RKLLGSLTSQ
910 920 930 940 950
EDAVMLQRRL DEMNQRWNNL KSKSIAIRNR LESNSEHWNA LLLSLRELTE
960 970 980 990 1000
WVIRKDTELS TLGLGPVRGD AVSLQKQLDD HKAFRRQLED KRPIVESNLT
1010 1020 1030 1040 1050
SGRQYIANEA AVSDTSDTEA NHDSDSRYMS AEEQSRELTR SIRREVGKLS
1060 1070 1080 1090 1100
EQWNNLIDRS DNWKHRLDEY MTKMRQFQKI LEDLSSRVAL AEQTKTSWLP
1110 1120 1130 1140 1150
PSSVGEANEQ MQQLQRLRDK MTTASALLDD CNEQQSFFTA NQVLVPTPCL
1160 1170 1180 1190 1200
SKLEDLNTRM KLLQIAMDER QKVLCQAGAQ QTHENGDDGR TTSNSGTIGP
1210 1220 1230 1240 1250
LPNLGQSVKP PWERATTAAN VPYYIDHERE TTHWDHPEMI ELMKGLADLN
1260 1270 1280 1290 1300
EIRFSAYRTA MKLRSVQKRL ALDRISMSTA CESFDRHGLR AQNDKLIDIP
1310 1320 1330 1340 1350
DMTTVLHSLY VTIDKIDLTL MLDLAINWIL NVYDSQRTGQ IRVLSFKVGL
1360 1370 1380 1390 1400
VLLCKGHLEE KYRYLFRLVA DTDRRADQRR LGLLLHDCIQ VPRQLGEVAA
1410 1420 1430 1440 1450
FGGSNIEPSV RSCLEQAGIS QEAIDGNQDI SIELQHFLGW LQHEPQSLVW
1460 1470 1480 1490 1500
LPVLHRLAAA EAAKHQAKCN ICKEYPIVGF RYRCLKCFNF DMCQKCFFFG
1510 1520 1530 1540 1550
RNAKNHKLTH PMHEYCTTTT STEDVRDFTR ALKNKFKSRK YFKKHPRVGY
1560 1570 1580 1590 1600
LPVQSVLEGD ALESPAPSPQ HTTHQLQNDM HSRLEMYASR LAQVEYGGTG
1610 1620 1630 1640 1650
SNSTPDSDDE HQLIAQYCQA LPGTSNGSAP KSPVQVMAAM DAEQREELEA
1660 1670 1680 1690 1700
IIRDLEEENA NLQAEYQQLC SKEQSGMPED SNGMQHSSSS MTGLSGQGEQ
1710 1720 1730 1740 1750
GQDMMAEAKL LRQHKGRLEA RMQILEDHNR QLEAQLQRLR QLLDEPNGGG
1760 1770 1780 1790 1800
SSATSSGLPS APGSALNSKP NTLQTRSVTA SQLNTDSPAK MNQQNGHYEH
1810 1820 1830 1840 1850
NSKNSSGLVT VITEQELESI NDDLEDSSSS NTTNTTTTTT TTATTEKTCV

ELQK
Length:1,854
Mass (Da):205,723
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1264435B6A5ECF2E
GO
Isoform A1 Publication (identifier: Q9VDW6-1) [UniParc]FASTAAdd to basket
Also known as: DLP2By similarity
The sequence of this isoform can be found in the external entry Q9VDW6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:3,497
Mass (Da):399,402
GO
Isoform B1 Publication (identifier: Q9VDW3-1) [UniParc]FASTAAdd to basket
Also known as: Dp186By similarity
The sequence of this isoform can be found in the external entry Q9VDW3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,669
Mass (Da):185,311
GO
Isoform C1 Publication (identifier: Q9VDW6-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9VDW6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:3,228
Mass (Da):369,072
GO
Isoform E1 Publication (identifier: Q7YU29-1) [UniParc]FASTAAdd to basket
Also known as: Dp1171 Publication
The sequence of this isoform can be found in the external entry Q7YU29.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,051
Mass (Da):116,741
GO
Isoform F1 Publication (identifier: Q9VDW6-3) [UniParc]FASTAAdd to basket
Also known as: DLP1By similarity
The sequence of this isoform can be found in the external entry Q9VDW6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:3,630
Mass (Da):414,187
GO
Isoform G1 Publication (identifier: Q9VDW6-4) [UniParc]FASTAAdd to basket
Also known as: DLP3By similarity
The sequence of this isoform can be found in the external entry Q9VDW6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:3,605
Mass (Da):411,189
GO
Isoform H1 Publication (identifier: Q9VDW6-5) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9VDW6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:3,598
Mass (Da):410,414
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KGH0A0A0B4KGH0_DROME
Dystrophin, isoform K
Dys CG17750, CG31175, CG7240, CG7243, CG7344
3,144Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHR4A0A0B4KHR4_DROME
Dystrophin, isoform I
Dys CG17750, CG31175, CG7240, CG7243, CG7344
3,228Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KGB9A0A0B4KGB9_DROME
Dystrophin, isoform L
Dys CG17750, CG31175, CG7240, CG7243, CG7344
1,323Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHE2A0A0B4KHE2_DROME
Dystrophin, isoform J
Dys CG17750, CG31175, CG7240, CG7243, CG7344
1,152Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence DAA04178 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti972V → A in AAX59985 (PubMed:16198353).Curated1
Sequence conflicti1039T → R in AAX59985 (PubMed:16198353).Curated1
Sequence conflicti1057I → L in AAX59985 (PubMed:16198353).Curated1
Sequence conflicti1230E → Q in AAX59985 (PubMed:16198353).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY875639 mRNA Translation: AAX59985.1
AE014297 Genomic DNA Translation: ABI31177.1
BK002672 Genomic DNA Translation: DAA04178.1 Sequence problems.

NCBI Reference Sequences

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RefSeqi
NP_001036725.1, NM_001043260.2 [Q0KI50-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0110915; FBpp0110215; FBgn0260003 [Q0KI50-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
42327

UCSC genome browser

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UCSCi
CG34157-RD, d. melanogaster [Q0KI50-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875639 mRNA Translation: AAX59985.1
AE014297 Genomic DNA Translation: ABI31177.1
BK002672 Genomic DNA Translation: DAA04178.1 Sequence problems.
RefSeqiNP_001036725.1, NM_001043260.2 [Q0KI50-1]

3D structure databases

SMRiQ0KI50
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi67322, 74 interactors
IntActiQ0KI50, 5 interactors

PTM databases

iPTMnetiQ0KI50

Proteomic databases

PRIDEiQ0KI50

Genome annotation databases

EnsemblMetazoaiFBtr0110915; FBpp0110215; FBgn0260003 [Q0KI50-1]
GeneIDi42327
UCSCiCG34157-RD, d. melanogaster [Q0KI50-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
42327
FlyBaseiFBgn0260003, Dys

Phylogenomic databases

GeneTreeiENSGT00940000166230
HOGENOMiCLU_236807_0_0_1

Enzyme and pathway databases

SignaLinkiQ0KI50

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
42327, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
42327

Gene expression databases

BgeeiFBgn0260003, Expressed in spermathecum and 59 other tissues
ExpressionAtlasiQ0KI50, baseline and differential
GenevisibleiQ0KI50, DM

Family and domain databases

CDDicd00201, WW, 1 hit
Gene3Di3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR018159, Spectrin/alpha-actinin
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PfamiView protein in Pfam
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00569, ZZ, 1 hit
SMARTiView protein in SMART
SM00150, SPEC, 3 hits
SM00456, WW, 1 hit
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
SSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS50020, WW_DOMAIN_2, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMDD_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0KI50
Secondary accession number(s): Q2VQZ5, Q6IJP4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 3, 2006
Last modified: October 7, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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