Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 107 (12 Aug 2020)
Sequence version 2 (16 Oct 2013)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Protein mesh

Gene

mesh

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required, together with Ssk and Tsp2A, for the proper organization of smooth septate junctions (sSJs), probably by mediating cell adhesion via its homophilic interaction (PubMed:22854041, PubMed:26848177). Also required for the correct subcellular localization of several sSJ components, such as Ssk, cora and l2gl, and for the barrier function of the midgut epithelium (PubMed:22854041). Required for maintaining the three-layered structure of the proventriculus (PubMed:22854041).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell-matrix adhesion Source: InterPro
  • multicellular organism development Source: UniProtKB-KW
  • smooth septate junction assembly Source: FlyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-913709, O-linked glycosylation of mucins
R-DME-977068, Termination of O-glycan biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mesh
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mesh
ORF Names:CG31004
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0051004, mesh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 1186ExtracellularSequence analysisAdd BLAST1165
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1187 – 1207HelicalSequence analysisAdd BLAST21
Topological domaini1208 – 1454CytoplasmicSequence analysisAdd BLAST247

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Homozygous larval lethal. Mutant embryos hatch into the first instar larvae, but die within 1 day. In mutant larvae midgut, a few septa are present at the cell contacts but large gaps between the lateral membranes of adjacent epithelial cells are frequently observed. Mutant larvae lack the three-layered structure of the proventriculus.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000035563722 – 1454Protein meshAdd BLAST1433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi554N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi888N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi942N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi977N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi985N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1048N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1066N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1121 ↔ 1161By similarity
Disulfide bondi1147 ↔ 1177By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1249Phosphoserine1 Publication1
Modified residuei1251Phosphothreonine1 Publication1
Modified residuei1254Phosphoserine1 Publication1
Modified residuei1295Phosphothreonine1 Publication1
Modified residuei1297Phosphoserine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0KHY3

PRoteomics IDEntifications database

More...
PRIDEi
Q0KHY3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0KHY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

At embryonic stage 12, expressed in endoderm-derived tissues (at protein level) (PubMed:22854041). In late-stage embryos, third-instar larvae and adult flies, expressed in the midgut, outer epithelial layer of the proventriculus and Malpighian tubules, but not expressed in the foregut and hindgut (at protein level) (PubMed:22854041, PubMed:26848177).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryonic, larval and adult stages (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0051004, Expressed in embryo and 30 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0KHY3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0KHY3, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with Ssk and Tsp2A (PubMed:26848177).

Interacts with Ssk; the interaction may be necessary for the localization of both proteins to the cell apicolateral region (PubMed:22854041).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
68533, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q0KHY3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0290183

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0KHY3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini259 – 425NIDOPROSITE-ProRule annotationAdd BLAST167
Domaini656 – 807AMOPPROSITE-ProRule annotationAdd BLAST152
Domaini821 – 1052VWFDPROSITE-ProRule annotationAdd BLAST232
Domaini1119 – 1179SushiPROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4291, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000110943

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0KHY3

KEGG Orthology (KO)

More...
KOi
K23820

Identification of Orthologs from Complete Genome Data

More...
OMAi
QAYEYKP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0KHY3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005533, AMOP_dom
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR003886, NIDO_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR001846, VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03782, AMOP, 1 hit
PF06119, NIDO, 1 hit
PF00084, Sushi, 1 hit
PF00094, VWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00723, AMOP, 1 hit
SM00032, CCP, 1 hit
SM00539, NIDO, 1 hit
SM00216, VWD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535, SSF57535, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50856, AMOP, 1 hit
PS51220, NIDO, 1 hit
PS50923, SUSHI, 1 hit
PS51233, VWFD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 3 (identifier: Q0KHY3-3) [UniParc]FASTAAdd to basket
Also known as: D

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRFKLFVVCA LACGFMAFVL ANENISTEEF EDQIINAVPE PVKVTKPKAQ
60 70 80 90 100
AEFVEVPKAT PAPKKAEADN PKTKPLALQK PTLIPVVHVS SRGTDDILTV
110 120 130 140 150
AGLKPEKMFG ALIMPNDYLG ELYDVDNSGY NWDPNNNVAP PTTYSTAAGG
160 170 180 190 200
YTITAARLAE LRSNFMYWYF DKDMYGGRGD YQFDIHASMT QLHKNLNFQL
210 220 230 240 250
PFYGFRFNYT RLSLNGYLEF SDPPEYLTYP LVFPIKDWPA KRDPSFMGIF
260 270 280 290 300
FSKCRVGRIY PSDIDQRTPG VYFRVERDLM GRTDRFGVEV RERTMWDIRQ
310 320 330 340 350
GVVGADTFIP KHVVIATWKN VSFAGGIDNS LYTTNTFQMV LATDEVYTYI
360 370 380 390 400
IFNYAVLNWL SHTEAGGDTT KGEGGVPAYV GFNAGNGTQA YEYNPYSQNM
410 420 430 440 450
VIRDLANRGW ANGFPGRHIF RVDEQILIGS CNKDIDAALL PLTFAPESGN
460 470 480 490 500
MLGGQVVNIT GPCFDPAIRV TCHFDTESVL GTYVDRNRVI CVQPYLKAEG
510 520 530 540 550
YIRFQISVGT QRFKWRGKYF VETPAAATEK IFFTTDDVHK KNPAEIRITW
560 570 580 590 600
NQYNLTSNAN ANVMISLWGY RETKIEPQLE YIDVIEASYS NSGSYVITPS
610 620 630 640 650
NYINRNNINR DMQFGFLQIN LTQPDQYSGL AISPVLWSRP IPLAWYMAPQ
660 670 680 690 700
WERQHGKRWA RALCDNWIRA DRFLRNFAAD LPLCPCTLDQ AVLDKGRFRP
710 720 730 740 750
DRECDKDSNP SCLRHRGAIH CVVSGTPVAQ GAEQQCCYDR YGFLMLTYDQ
760 770 780 790 800
MWGSRPRRVH NLGKMPWNEA SKVPSLSMWF HDMRPFYSCC YWQEEQAVGC
810 820 830 840 850
ETYRFERRPS QDCVAYQAPG IAGVFGDPHF VTFDGTAYTF NGLGEFVLAR
860 870 880 890 900
SVDESNKFEV QGRFEQLPVN YYGEVKATQL TAVAMRGNTT TTIEVRLRPL
910 920 930 940 950
HARWRYRLDV LADGRRVYFD RESLKFQHFD GVTVYTPTYL LNQSQVVVQF
960 970 980 990 1000
DAGIGVEVVE NEGYMTGRVF LPWKFINKTA GLFGNWSFNK LDDFMLPNGQ
1010 1020 1030 1040 1050
VAQLNLNDLR SIHTNFGIKW MLTDREVPGV GAALFKREFG RMSGYYANAT
1060 1070 1080 1090 1100
FQPNYVLDPA DFLPANRSYD LERAEELCGE CMQCQYDYAM TLNRDLAHFT
1110 1120 1130 1140 1150
KNYYDTIVNM QAENAVRVVS CGVLQTPRFG RKLSFDFMPG AKVSFECNEG
1160 1170 1180 1190 1200
FILIGDQRRE CLSNGLWNIP EYGYTECLRE VYYTRRVAFI AIGIIFLVIC
1210 1220 1230 1240 1250
PLMLCIVCGV YRYRQKQLKE DPQWQMPMLP RSRASSARNL RTLNYDDDSD
1260 1270 1280 1290 1300
TDASTLKKSR SYDKVYRTNE PLPGKPQIDF PAKKWDLDEN DEDVTSSEGE
1310 1320 1330 1340 1350
KPKQLGRRSL HSASGTELDQ HGSPVDGDHP DEDDDFDEAD VHTGTTHPVG
1360 1370 1380 1390 1400
YHQPLSPEEA DQLHRQQYSP TFSGLDSRTS GASSINYTPQ AATQNRFGGV
1410 1420 1430 1440 1450
PVLPSNTQYY SRPPSSVNTV PLRTAPTPLT QDTGLPSPPL ATSPTPSVQK

STEV
Length:1,454
Mass (Da):165,038
Last modified:October 16, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C8C1239C69EA6F8
GO
Isoform 1 (identifier: Q0KHY3-1) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1259-1282: SRSYDKVYRTNEPLPGKPQIDFPA → T

Show »
Length:1,431
Mass (Da):162,378
Checksum:i7C7F4C01CC052DFC
GO
Isoform 2 (identifier: Q0KHY3-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1180-1454: EVYYTRRVAF...TPSVQKSTEV → HEERSARVAS...KWQQSKQHVI

Show »
Length:1,243
Mass (Da):141,756
Checksum:iF5C304D0A958C589
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LHZ4A0A0B4LHZ4_DROME
Mesh, isoform E
mesh anon-WO0140519.233, CG12074, CG15560, CT5150, Dmel\CG31004
1,243Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM52621 differs from that shown. Reason: Frameshift.Curated
The sequence AAR96152 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti686C → Y in AAM52621 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0359561180 – 1454EVYYT…KSTEV → HEERSARVASISLGMVLLIL IPCLLLLVCGASYWIRERIA REEEEAAQALLPKSKWQQSK QHVI in isoform 2. 1 PublicationAdd BLAST275
Alternative sequenceiVSP_0532821259 – 1282SRSYD…IDFPA → T in isoform 1. 2 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF57124.2
AE014297 Genomic DNA Translation: ACZ95074.1
AE014297 Genomic DNA Translation: ACZ95075.1
AE014297 Genomic DNA Translation: AAF57123.2
BT032891 mRNA Translation: ACD99455.1
BT133164 mRNA Translation: AEZ02857.1
BT011360 mRNA Translation: AAR96152.1 Frameshift.
AY122109 mRNA Translation: AAM52621.1 Frameshift.

NCBI Reference Sequences

More...
RefSeqi
NP_001163781.1, NM_001170310.1 [Q0KHY3-2]
NP_001163782.1, NM_001170311.1 [Q0KHY3-3]
NP_001287618.1, NM_001300689.1 [Q0KHY3-2]
NP_733418.1, NM_170539.1 [Q0KHY3-1]
NP_733419.1, NM_170540.1 [Q0KHY3-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0085779; FBpp0085140; FBgn0051004 [Q0KHY3-1]
FBtr0085780; FBpp0085141; FBgn0051004 [Q0KHY3-1]
FBtr0300960; FBpp0290182; FBgn0051004 [Q0KHY3-2]
FBtr0300961; FBpp0290183; FBgn0051004 [Q0KHY3-3]
FBtr0344066; FBpp0310483; FBgn0051004 [Q0KHY3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43688

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG31004

UCSC genome browser

More...
UCSCi
CG31004-RA, d. melanogaster [Q0KHY3-3]
CG31004-RB, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF57124.2
AE014297 Genomic DNA Translation: ACZ95074.1
AE014297 Genomic DNA Translation: ACZ95075.1
AE014297 Genomic DNA Translation: AAF57123.2
BT032891 mRNA Translation: ACD99455.1
BT133164 mRNA Translation: AEZ02857.1
BT011360 mRNA Translation: AAR96152.1 Frameshift.
AY122109 mRNA Translation: AAM52621.1 Frameshift.
RefSeqiNP_001163781.1, NM_001170310.1 [Q0KHY3-2]
NP_001163782.1, NM_001170311.1 [Q0KHY3-3]
NP_001287618.1, NM_001300689.1 [Q0KHY3-2]
NP_733418.1, NM_170539.1 [Q0KHY3-1]
NP_733419.1, NM_170540.1 [Q0KHY3-1]

3D structure databases

SMRiQ0KHY3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi68533, 2 interactors
IntActiQ0KHY3, 1 interactor
STRINGi7227.FBpp0290183

PTM databases

iPTMnetiQ0KHY3

Proteomic databases

PaxDbiQ0KHY3
PRIDEiQ0KHY3

Genome annotation databases

EnsemblMetazoaiFBtr0085779; FBpp0085140; FBgn0051004 [Q0KHY3-1]
FBtr0085780; FBpp0085141; FBgn0051004 [Q0KHY3-1]
FBtr0300960; FBpp0290182; FBgn0051004 [Q0KHY3-2]
FBtr0300961; FBpp0290183; FBgn0051004 [Q0KHY3-3]
FBtr0344066; FBpp0310483; FBgn0051004 [Q0KHY3-2]
GeneIDi43688
KEGGidme:Dmel_CG31004
UCSCiCG31004-RA, d. melanogaster [Q0KHY3-3]
CG31004-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43688
FlyBaseiFBgn0051004, mesh

Phylogenomic databases

eggNOGiKOG4291, Eukaryota
GeneTreeiENSGT00730000110943
InParanoidiQ0KHY3
KOiK23820
OMAiQAYEYKP
PhylomeDBiQ0KHY3

Enzyme and pathway databases

ReactomeiR-DME-913709, O-linked glycosylation of mucins
R-DME-977068, Termination of O-glycan biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
43688, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43688

Protein Ontology

More...
PROi
PR:Q0KHY3

Gene expression databases

BgeeiFBgn0051004, Expressed in embryo and 30 other tissues
ExpressionAtlasiQ0KHY3, baseline and differential
GenevisibleiQ0KHY3, DM

Family and domain databases

CDDicd00033, CCP, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR005533, AMOP_dom
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR003886, NIDO_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR001846, VWF_type-D
PfamiView protein in Pfam
PF03782, AMOP, 1 hit
PF06119, NIDO, 1 hit
PF00084, Sushi, 1 hit
PF00094, VWD, 1 hit
SMARTiView protein in SMART
SM00723, AMOP, 1 hit
SM00032, CCP, 1 hit
SM00539, NIDO, 1 hit
SM00216, VWD, 1 hit
SUPFAMiSSF57535, SSF57535, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50856, AMOP, 1 hit
PS51220, NIDO, 1 hit
PS50923, SUSHI, 1 hit
PS51233, VWFD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMESH_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0KHY3
Secondary accession number(s): B3DNA3
, E1JJ26, E1JJ27, E2QD49, Q6NND0, Q8MR59
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 16, 2013
Last modified: August 12, 2020
This is version 107 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again