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Entry version 142 (29 Sep 2021)
Sequence version 1 (03 Oct 2006)
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Protein

Serine/threonine-protein kinase Pink1, mitochondrial

Gene

Pink1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase which protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as park and likely Drp1, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:18957282, PubMed:18799731, PubMed:18443288, PubMed:24901221, PubMed:16938835, PubMed:32484300, PubMed:16672980, PubMed:16672981, PubMed:20194754, PubMed:18230723, PubMed:16818890, PubMed:25474007, PubMed:22645651).

Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:18957282, PubMed:18799731, PubMed:18443288, PubMed:24901221, PubMed:16938835, PubMed:16672980, PubMed:16672981, PubMed:20194754, PubMed:18230723, PubMed:16818890, PubMed:23509287, PubMed:25474007).

Appears to be particularly important in maintaining the physiology and function of cells with high energy demands that are undergoing stress or altered metabolic environment, including spermatids, muscle cells and neurons such as the dopaminergic (DA) neurons (PubMed:16672980, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18443288, PubMed:18799731, PubMed:22396657, PubMed:24901221, PubMed:28435104, PubMed:32138754).

Mediates the translocation and activation of park at the outer membrane (OMM) of dysfunctional/depolarized mitochondria (PubMed:24901221, PubMed:20194754, PubMed:18957282, PubMed:18799731, PubMed:25474007, PubMed:27906179).

At the OMM of damaged mitochondria, phosphorylates pre-existing polyubiquitin chains, the Pink1-phosphorylated polyubiquitin then recruits park from the cytosol to the OMM where park is fully activated by phosphorylation at 'Ser-94' by Pink1 (PubMed:24901221, PubMed:20194754, PubMed:18957282, PubMed:18799731, PubMed:25474007, PubMed:27906179).

When cellular stress results in irreversible mitochondrial damage, functions with park to promote the clearance of dysfunctional and/or depolarized mitochondria by selective autophagy (mitophagy) (PubMed:16672980, PubMed:16672981, PubMed:20194754, PubMed:18957282, PubMed:23509287, PubMed:25474007).

The Pink1-park pathway also promotes fission and/or inhibits fusion of damaged mitochondria, by phosphorylating and thus promoting the park-dependent degradation of proteins involved in mitochondrial fusion/fission such as Marf, Opa1 and fzo (PubMed:18443288, PubMed:18799731, PubMed:18230723, PubMed:20194754, PubMed:24901221).

This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:18799731, PubMed:18230723, PubMed:20194754, PubMed:24901221).

Also likely to promote mitochondrial fission independently of park and Atg7-mediated mitophagy, via the phosphorylation and activation of Drp1 (PubMed:18443288, PubMed:32484300).

Regulates motility of damaged mitochondria by phosphorylating Miro which likely promotes its park-dependent degradation by the proteasome; in motor neurons, this inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria being eliminated in the soma (PubMed:22396657).

The Pink1-park pathway is also involved in mitochondrial regeneration processes such as promoting mitochondrial biogenesis, activating localized mitochondrial repair, promoting selective turnover of mitochondrial proteins and initiating the mitochondrial import of endogenous proteins (PubMed:16672980, PubMed:23509287, PubMed:30772175).

Involved in mitochondrial biogenesis by promoting the park-dependent ubiquitination of transcriptional repressor Paris which leads to its subsequent proteasomal degradation and allows activation of the transcription factor srl (PubMed:32138754).

Functions with park to promote localized mitochondrial repair by activating the translation of specific nuclear-encoded mitochondrial RNAs (nc-mtRNAs) on the mitochondrial surface, including several key electron transport chain component nc-mtRNAs (PubMed:23509287).

During oogenesis, phosphorylates and inactivates larp on the membrane of defective mitochondria, thus impairing local translation and mtDNA replication and consequently, reducing transmission of deleterious mtDNA mutations to the mature oocyte (PubMed:30772175).

19 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei337ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei479Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi310 – 318ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processAutophagy
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5205685, PINK1-PRKN Mediated Mitophagy

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q0KHV6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase Pink1, mitochondrialCurated (EC:2.7.11.12 Publications)
Alternative name(s):
PTEN-induced putative kinase 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pink11 PublicationImported
ORF Names:CG4523Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0029891, Pink1

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
VectorBase:FBgn0029891

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini6 – 136Mitochondrial intermembraneCuratedAdd BLAST131
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei137 – 153HelicalSequence analysisAdd BLAST17
Topological domaini154 – 721CytoplasmicCuratedAdd BLAST568

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Adults display various phenotypes that appear to be the result of mitochondrial abnormalities and/or mitochondrial dysfunction (PubMed:16672980, PubMed:16672981, PubMed:18799731, PubMed:18443288, PubMed:24901221, PubMed:27906179, PubMed:30772175). In various tissues including the indirect flight muscles (IFM), thoracic muscles, sperm, cardiomyocytes and neurons including the dopaminergic (DA) neurons, mitochondria display abnormalities such as swelling, loss of cristae, fragmentation, aggregation and/or mitochondrial disorganization, and they are dysfunctional resulting in defects such as mitochondrial depolarization, increased reactive oxygen species (ROS) production, reduced ATP, decreased mitochondrial DNA and reduced mitochondrial protein levels (PubMed:16672980, PubMed:16672981, PubMed:18443288, PubMed:18799731, PubMed:24901221, PubMed:27906179, PubMed:23509287). As a result adults are reduced in size, display reduced survival and decreased fertility (PubMed:16672980, PubMed:16672981, PubMed:18799731). They also exhibit age-dependent and progressive degradation of the IFM and DA neurons, especially in the protocerebral posterior lateral 1 (PPL1) cluster, which likely contribute to the observed locomotive defects, down-turned rigid wings and crushed thorax phenotypes (PubMed:16672980, PubMed:18443288, PubMed:24901221, PubMed:27906179). Also affects non-motor behaviors such as reduced learning, intermediate-term memory and irregular circadian rhythms under constant darkness, likely as a result of the neurodegradation (PubMed:28435104). On the surface of mitochondria enriched with a deleterious mutation, negative regulation of larp-mediated protein synthesis is reduced, and as a consequence the transmission of the deleterious mtDNA mutation to the mature oocyte is more random compared to control oocytes which display decreased inheritance of the mutation (PubMed:30772175). RNAi-mediated knockdown increases the net velocity of anterograde mitochondrial transport in motor neurons, whereas retrograde transport is largely unaffected (PubMed:22396657). Double knockout of Pink1 and park display no increase in the severity of their phenotypes compared to single mutants (PubMed:16672980). However, expression of park in Pink1 mutants markedly rescues most of the Pink1 mutant phenotypes, whereas expression of Pink1 in park mutants fails to rescue the defective thorax and abnormal wing position (PubMed:16672980). Double knockout of Pink1 and Drp1 severely disrupts mitochondrial fusion resulting in mitochondrial aggregates and long threads of mitochondrial tubules (PubMed:18443288). Double knockdown with Paris, improves climbing performance defects and rescues decreased mRNA levels of srl, ewg and TFAM, observed in Pink1 mutants (PubMed:32138754).11 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi337K → R: Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with A-479 and A-501. 2 Publications1
Mutagenesisi346S → A: Abolishes activity and autophosphorylation. Fails to recruit park to mitochondria. 1 Publication1
Mutagenesisi346S → D: Phosphomimetic mutant; no effect on activity and promotes translocation of park to mitochondria. 1 Publication1
Mutagenesisi479D → A: Loss of kinase activity and impaired recruitment of park to mitochondria. Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with R-337 and A-501. 3 Publications1
Mutagenesisi501D → A: Loss of kinase activity. Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with R-337 and A-479. 3 Publications1
Mutagenesisi519S → A: No effect on activity and autophosphorylation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 5MitochondrionSequence analysis5
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004523656 – 721Serine/threonine-protein kinase Pink1, mitochondrialSequence analysisAdd BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei346Phosphoserine; by autocatalysis2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved (PubMed:19048081). In healthy cells, the precursor is continuously imported into mitochondria where it is proteolytically cleaved into its short form by the mitochondrial rhomboid protease rho-7 (PubMed:19048081). The short form is then released into the cytosol where it rapidly undergoes proteasome-dependent degradation (Probable). In unhealthy cells, when cellular stress conditions lead to the loss of mitochondrial membrane potential, mitochondrial import is impaired leading to the precursor accumulating on the outer mitochondrial membrane (OMM) (PubMed:27906179).1 Publication2 Publications
Autophosphorylated on Ser-346, which activates kinase activity (PubMed:25474007, PubMed:27906179). Loss of mitochondrial membrane potential results in the precursor accumulating on the outer mitochondrial membrane (OMM) where it is activated by autophosphorylation at Ser-346 (PubMed:27906179). Autophosphorylation is sufficient and essential for selective recruitment of park to depolarized mitochondria, likely via Pink1-dependent phosphorylation of polyubiquitin chains (PubMed:25474007, PubMed:27906179).2 Publications

Keywords - PTMi

Phosphoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression in the brain and retinas (PubMed:16938835). High expression in the head and testes (PubMed:16672981). High expression in the thorax compared to the head and abdomen (PubMed:16672980).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout development, with high levels of expression in adults and low levels of expression in larvae and pupae (PubMed:16672980, PubMed:16672981). Adult males display higher levels of expression than females (PubMed:16672980).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0029891, Expressed in adult tagma (Drosophila) and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q0KHV6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with park (PubMed:19048081).

Interacts with rho-7 and HtrA2 (PubMed:19048081).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q0KHV6, 4 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0099837

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q0KHV6

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini304 – 638Protein kinasePROSITE-ProRule annotationAdd BLAST335

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni279 – 322DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi284 – 299Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi300 – 322Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4158, Eukaryota
ENOG410YE6P, LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000001206

Identification of Orthologs from Complete Genome Data

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OMAi
FGQHARK

Database of Orthologous Groups

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OrthoDBi
EOG091G03V6

Database for complete collections of gene phylogenies

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PhylomeDBi
Q0KHV6

Family and domain databases

Conserved Domains Database

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CDDi
cd14018, STKc_PINK1, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR040110, PINK1_STKc
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

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Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q0KHV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVRLLTVRL IKHGRYILRS YCKRDIHANI LDQNQLKTRS KRGFPLPSTA
60 70 80 90 100
ANVLRTTPQQ AAKSVVNVVP RTINSPSGSP FNGSGSSPTS SSGIFRVGQH
110 120 130 140 150
ARKLFIDNIL SRVTTTYSED LRQRATRKLF FGDSAPFFAL IGVSLASGSG
160 170 180 190 200
VLSKEDELEG VCWEIREAAS RLQNAWNHDE ISDTLDSKFT IDDLEIGPPI
210 220 230 240 250
AKGCAAVVYA ADFKKDVASD GASLHTDAQP QATPAFAPNS WSTHEMMSPL
260 270 280 290 300
QNMSRFVHNF GGSVDNVFHY SQPSAASDFV GAQSREQDQR HHEQQQHQNQ
310 320 330 340 350
EQEQHQNQEP SSSAFNVTSP ANSNINSSVD SYPLALKMMF NYDIQSNALS
360 370 380 390 400
ILRAMYKETV PARQRGMNEA ADEWERLLQN QTVHLPRHPN IVCMFGFFCD
410 420 430 440 450
EVRNFPDGHL LYPVAQPQRI NPQGYGRNMS LYLLMKRYDH SLRGLLDSQD
460 470 480 490 500
LSTRNRILLL AQMLEAVNHL SRHGVAHRDL KSDNVLIELQ DDAAPVLVLS
510 520 530 540 550
DFGCCLADKV HGLRLPYVSH DVDKGGNAAL MAPEIFNTMP GPFAVLNYGK
560 570 580 590 600
ADLWACGALA YEIFGNRNPF YSSSGGMARE RGEMTLSLRN SDYRQDQLPP
610 620 630 640 650
MSDACPPLLQ QLVYNILNPN PSKRVSPDIA ANVVQLFLWA PSNWLKAGGM
660 670 680 690 700
PNSPEILQWL LSLTTKIMCE GRPQMGAGLM PVASCGNRRA YVEYLLICSF
710 720
LARARLRRIR GALNWIQNVV A
Length:721
Mass (Da):80,228
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9764EBF46B443F2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti186D → H in AAK92983 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46188.1
AE014298 Genomic DNA Translation: AAN09178.1
AE014298 Genomic DNA Translation: AAZ52497.1
AE014298 Genomic DNA Translation: AAZ52498.1
AE014298 Genomic DNA Translation: AAZ52499.1
AE014298 Genomic DNA Translation: AAZ52500.1
AE014298 Genomic DNA Translation: AAZ52501.1
AE014298 Genomic DNA Translation: AAZ52502.1
AE014298 Genomic DNA Translation: AHN59423.1
AY051559 mRNA Translation: AAK92983.1
BT133188 mRNA Translation: AFA28429.1

NCBI Reference Sequences

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RefSeqi
NP_001027049.1, NM_001031878.2
NP_001027050.1, NM_001031879.3
NP_001027051.1, NM_001031880.3
NP_001027052.1, NM_001031881.3
NP_001027053.1, NM_001031882.3
NP_001027054.1, NM_001031883.3
NP_001284952.1, NM_001298023.1
NP_572340.2, NM_132112.5
NP_727110.1, NM_167083.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070956; FBpp0070917; FBgn0029891
FBtr0070957; FBpp0070918; FBgn0029891
FBtr0100413; FBpp0099830; FBgn0029891
FBtr0100414; FBpp0099831; FBgn0029891
FBtr0100415; FBpp0099832; FBgn0029891
FBtr0100416; FBpp0099833; FBgn0029891
FBtr0100419; FBpp0099835; FBgn0029891
FBtr0100420; FBpp0099837; FBgn0029891
FBtr0345295; FBpp0311462; FBgn0029891

Database of genes from NCBI RefSeq genomes

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GeneIDi
31607

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG4523

UCSC genome browser

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UCSCi
CG4523-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46188.1
AE014298 Genomic DNA Translation: AAN09178.1
AE014298 Genomic DNA Translation: AAZ52497.1
AE014298 Genomic DNA Translation: AAZ52498.1
AE014298 Genomic DNA Translation: AAZ52499.1
AE014298 Genomic DNA Translation: AAZ52500.1
AE014298 Genomic DNA Translation: AAZ52501.1
AE014298 Genomic DNA Translation: AAZ52502.1
AE014298 Genomic DNA Translation: AHN59423.1
AY051559 mRNA Translation: AAK92983.1
BT133188 mRNA Translation: AFA28429.1
RefSeqiNP_001027049.1, NM_001031878.2
NP_001027050.1, NM_001031879.3
NP_001027051.1, NM_001031880.3
NP_001027052.1, NM_001031881.3
NP_001027053.1, NM_001031882.3
NP_001027054.1, NM_001031883.3
NP_001284952.1, NM_001298023.1
NP_572340.2, NM_132112.5
NP_727110.1, NM_167083.4

3D structure databases

SMRiQ0KHV6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ0KHV6, 4 interactors
STRINGi7227.FBpp0099837

Genome annotation databases

EnsemblMetazoaiFBtr0070956; FBpp0070917; FBgn0029891
FBtr0070957; FBpp0070918; FBgn0029891
FBtr0100413; FBpp0099830; FBgn0029891
FBtr0100414; FBpp0099831; FBgn0029891
FBtr0100415; FBpp0099832; FBgn0029891
FBtr0100416; FBpp0099833; FBgn0029891
FBtr0100419; FBpp0099835; FBgn0029891
FBtr0100420; FBpp0099837; FBgn0029891
FBtr0345295; FBpp0311462; FBgn0029891
GeneIDi31607
KEGGidme:Dmel_CG4523
UCSCiCG4523-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65018
FlyBaseiFBgn0029891, Pink1
VEuPathDBiVectorBase:FBgn0029891

Phylogenomic databases

eggNOGiKOG4158, Eukaryota
ENOG410YE6P, LUCA
GeneTreeiENSGT00390000001206
OMAiFGQHARK
OrthoDBiEOG091G03V6
PhylomeDBiQ0KHV6

Enzyme and pathway databases

ReactomeiR-DME-5205685, PINK1-PRKN Mediated Mitophagy
SignaLinkiQ0KHV6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31607, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31607

Gene expression databases

BgeeiFBgn0029891, Expressed in adult tagma (Drosophila) and 39 other tissues
ExpressionAtlasiQ0KHV6, baseline and differential

Family and domain databases

CDDicd14018, STKc_PINK1, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR040110, PINK1_STKc
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPINK1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0KHV6
Secondary accession number(s): Q961J3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 7, 2021
Last sequence update: October 3, 2006
Last modified: September 29, 2021
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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