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Entry version 126 (18 Sep 2019)
Sequence version 2 (03 Mar 2009)
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Protein
Submitted name:

Myosin 10A, isoform D

Gene

Myo10A

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi246 – 253ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, HydrolaseImported, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myosin 10A, isoform DImported (EC:3.6.1.3Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo10AImported
Synonyms:10AImported, AAF47980Imported, CG16922Imported, CG2136Imported, CG2174Imported, Dmel\CG43657Imported, DmXVImported, myo10AImported, Myo20Imported, SyphImported
ORF Names:CG43657Imported, Dmel_CG43657Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0263705 Myo10A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0KHU0

PRoteomics IDEntifications database

More...
PRIDEi
Q0KHU0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0263705 Expressed in 18 organ(s), highest expression level in imaginal disc

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0KHU0 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0KHU0 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0302017

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0KHU0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 840Myosin motorInterPro annotationAdd BLAST686
Domaini1014 – 1173MyTH4InterPro annotationAdd BLAST160
Domaini2658 – 2812MyTH4InterPro annotationAdd BLAST155
Domaini2817 – 3138FERMInterPro annotationAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni716 – 738Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni910 – 929DisorderedSequence analysisAdd BLAST20
Regioni1268 – 1440DisorderedSequence analysisAdd BLAST173
Regioni1651 – 1686DisorderedSequence analysisAdd BLAST36
Regioni1765 – 1788DisorderedSequence analysisAdd BLAST24
Regioni1824 – 1848DisorderedSequence analysisAdd BLAST25
Regioni1888 – 1910DisorderedSequence analysisAdd BLAST23
Regioni1955 – 2026DisorderedSequence analysisAdd BLAST72
Regioni2053 – 2120DisorderedSequence analysisAdd BLAST68
Regioni2176 – 2197DisorderedSequence analysisAdd BLAST22
Regioni2470 – 2594DisorderedSequence analysisAdd BLAST125

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi914 – 929PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1321 – 1335PolarSequence analysisAdd BLAST15
Compositional biasi1657 – 1680Pro-richSequence analysisAdd BLAST24
Compositional biasi1765 – 1780PolarSequence analysisAdd BLAST16
Compositional biasi1888 – 1905PolarSequence analysisAdd BLAST18
Compositional biasi1958 – 2011Pro-richSequence analysisAdd BLAST54
Compositional biasi2072 – 2096PolyampholyteSequence analysisAdd BLAST25
Compositional biasi2106 – 2120PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2176 – 2190PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2481 – 2594PolarSequence analysisAdd BLAST114

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4229 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155335

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0KHU0

KEGG Orthology (KO)

More...
KOi
K10361

Database of Orthologous Groups

More...
OrthoDBi
14609at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit
cd13201 FERM_C_MyoXV, 1 hit
cd01387 MYSc_Myo15, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.530, 2 hits
2.30.29.30, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR041795 MyoXV_FERM_C
IPR036057 MYSc_Myo15
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q0KHU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDWAEGDLVW FDPGMGHPIP GEIQEVHRAA QVIVVQALIK GKMRIVRFHL
60 70 80 90 100
EPWQRGGGGS VTPSPAQSPS LALLSPHVLR RQRPASLEDF EDLPNLSAKH
110 120 130 140 150
PALPSSRLRR LKCRYPQVVK RLSTLCSDVI ARHPQTFALQ PGEGSLRARQ
160 170 180 190 200
DLGSSGVEDM TLLDDLHEAS LLWNLRLRYD KGLIYTFAGS ILIAVNPYKM
210 220 230 240 250
FPDAYGLEVA KQYAGRPLGS LPPHLFAIGA AAHAALPSPQ VVVISGESGS
260 270 280 290 300
GKTESTKLVM QYLAAVVPGG GSASAVITEQ ILEAAPLLEA FGNARTARND
310 320 330 340 350
NSSRFGKYLE VYFKSGAIVG AKITQYLLEK SRIVTQAPGE RNYHVFYELL
360 370 380 390 400
GGLSETERSK YGLLEADKYF YLNQGATDCA SGRVDWESLQ GAMQVLGVSE
410 420 430 440 450
GEREGIVRVL AAVLHLGNVY FHRRQLRHGQ EGVEVGSDAE IKWAAHLLHI
460 470 480 490 500
SADGLHRALT SRTTEARAER LHTPLGIDQA LDARDAFAKA LYAGLFNWLV
510 520 530 540 550
SRINSIVQKG GTHDAHRISI LDIFGFEDLA ENSFEQLCIN YANENLQLYF
560 570 580 590 600
NKHVFKLEQA EYARERLEWT PLAWDDNLPV IHLLAKKPVG ICHLLDDESN
610 620 630 640 650
FPRATDLSFL EKCHYNHALS ELYARPRIGA QEFGVTHYAG QVWYCVDGFL
660 670 680 690 700
DKNRDALRGD VLELLASSRL PLVGELTKQL RAQRDAGKTL PKGSNGRFVT
710 720 730 740 750
MKPRTPTVAA RFADSLQQLL QSMGRCHPWF VRCIKPNQEK HALRMDMPCV
760 770 780 790 800
LQQLRYLGML DTIQIRQRGY PVRLRFQHFV ERYRHLLPSP LARGTPYREL
810 820 830 840 850
CRALLEAMPR TGVEGPDYQL GATRVFLREA LHRALESGRT ERLRRAAVSV
860 870 880 890 900
QRHVRGMLVR RQLARRQAAA TRLQARWRGQ RAQQRYERLR KGALTAQRLW
910 920 930 940 950
RGRQARRRVQ QLRSDHRRRQ EAREAAQRAR EAREAKQAVL ERSQLSYLDI
960 970 980 990 1000
PAELAFIYSK LQGWSPPHGD RHLVKVLGTV PGPPSSAVQL PEDLGQFSFG
1010 1020 1030 1040 1050
KFSSVYCNGL RLQPRREPIT APLLTRAASR DQDFQDALAV FKLILRWSND
1060 1070 1080 1090 1100
KALEGAKEKL LADYIVHKAL SSRGLRDEIL VQLCNQVHGL PPNSGEATRL
1110 1120 1130 1140 1150
WQLLGQCLCC FQPSAAFSKY LMRFVDDEAP ESLRPLLLRQ LLRQQGGGTS
1160 1170 1180 1190 1200
SGAVGAGACR SFVPAWLEWR AWTRGCDMAL PLTLPDEASQ TVAVDSWTSC
1210 1220 1230 1240 1250
EEAAALAVSS LGVASRGWTL VLDDGQQLTD SCGLDYVMDL IAEKELCPAF
1260 1270 1280 1290 1300
PAPRSDLLRS GAKFARTTLP DAVKRPAVPP PAPPTSSGKE DVPRERRSSR
1310 1320 1330 1340 1350
ELLSRSSALN ERYFEREPSP GPGQGSSTGQ AKSRSKSLDD LLAGDIVPVP
1360 1370 1380 1390 1400
TDCDSQEPLH TLGLSESRLN DRYHSAERLA PVGKDTGPRY QKSQHAGRRS
1410 1420 1430 1440 1450
HAASHGSHSS KYADKAEYAT RSSAMSDTSE APSLASHVRR VRVPSQASDV
1460 1470 1480 1490 1500
DQFLDDLFSP VLDGSLDELS DARSLAASIR GGSYEQENEA ESEIDDLDDY
1510 1520 1530 1540 1550
INDIFQPIPL VQNLEKLTSK DQLAAIIKGG GVASKPEERD EESEIEDLDD
1560 1570 1580 1590 1600
YINELFEPIP VAEGLDKLTS KEHLAVSIRG GGSTDSNGAD PLLHQLMQLP
1610 1620 1630 1640 1650
GETESGPALY QQQVQRAFLQ SAMAQNLQIQ QQLLAQNQAL QTLLSQQAAA
1660 1670 1680 1690 1700
AAANNSTSPP PAPPILSSLS ISPPPPQSPM RMKATRSSLV VMESLQPPPP
1710 1720 1730 1740 1750
PPPPPMPPPL ECKDPSETRH FLDPYGRAKT VRIGKWRWPP PQDEPQFQTE
1760 1770 1780 1790 1800
EDFFAFKMRQ HQRKTTPQAQ HHQMTSNGGM MESGPGARGA SATAIEWEEF
1810 1820 1830 1840 1850
EIESPTPPPM SGQLMRSSIR LETTTTTTTS AVNNRDRDRE TQDVGQPMQS
1860 1870 1880 1890 1900
VVTTKLAKKS FEIGADRPPP GSVGKLKLSS EMRQRLEQVT AGHSVRSTVS
1910 1920 1930 1940 1950
TKSEQRAPAK LEDTRKLMLQ QQLGGLFASV SGGNSGPGGV VDSHATVRTQ
1960 1970 1980 1990 2000
IERMEGKLSP PPAPPSGGWP GVLLPPAPSV PAPPPPIRPP SMAPPAPPPA
2010 2020 2030 2040 2050
PQSPPTARSP EPEPDYRTSS SQVVKEHVPA FIQRQERDTF GAVRQQQMIS
2060 2070 2080 2090 2100
SHHLHLEDHS ASSSPAVAAW EQAERERSRS RSRSRDREDY SESVWDRAEV
2110 2120 2130 2140 2150
EGPASGSGSE KEREKRERER ERLYEIRQVE RERESHKVYQ PAPPRVIQAS
2160 2170 2180 2190 2200
MDTTGGHRRE DRTGGLATFR THMAQKYEHE RKRKSSASSG MREELDSMHM
2210 2220 2230 2240 2250
TTPPPVIVPA PVPPPSSTSP GLGVVSGVLM GSGSGGSTAC LTYNRVPWKL
2260 2270 2280 2290 2300
RVRKEVFQPH EPIGPPVALD LLFAQVLGDV FGVTPCLRIT PQEKSSALNM
2310 2320 2330 2340 2350
LHGHGVSVDT LSNRNGSGAG GGGNGGQVRA LVKRHLVDMA RDWPLYFARL
2360 2370 2380 2390 2400
FAVQGAPLYP DVSIMGVSHS GLYLARRDAD YLIVVQAISF GEIQSAVTLP
2410 2420 2430 2440 2450
RPAALQLNLR NGKHLALHAA RAAAIQSMVT TFVQEFRKSQ SKASTLSSGA
2460 2470 2480 2490 2500
RAAAQTLNVP LERLESRQAH AQRNEHGVDG GSRQNEQLQQ SELHHHLQQQ
2510 2520 2530 2540 2550
QQQQQQQQHH QQQQQQQQLE DAMEEQHMAT DHQQQQQQQL GQQQGQQQRF
2560 2570 2580 2590 2600
LKQQSYLHSA RKSNAGQQPS SLTNGQVHHQ EQMLQQQQQQ SQSLPHHDLD
2610 2620 2630 2640 2650
ANYLQDESNG GTPPSVTKYS LLQFAMQHFR NDQLRDADRH HERHQSAANR
2660 2670 2680 2690 2700
SYAELVKWQG HAIRLPLLRL PNDLAPLALE CFDCILRYCG DIPLDPDLTE
2710 2720 2730 2740 2750
VKCVYTVLMH CHKYLALRDE VYCQLMKQTT ANRSPCPDSS QRAWRLLSIL
2760 2770 2780 2790 2800
AAYFGCSDAL RPYLMEHLTS AASDRRRSCH GTAAVCLTNL RKTARCGGRK
2810 2820 2830 2840 2850
NVPSVEEVTA VSAGRSARRQ IYRLPGGAER VVNTRCSTVV ADVIAELCAL
2860 2870 2880 2890 2900
LGVESEAEQQ EFSLYCIVQG DAFTMPLAAD EYILDVTTEL LKSGQPFYLI
2910 2920 2930 2940 2950
FCRSVWHFAL KREPAPMPLY VEVLFNQVAP DYLEGLLLEL PGNGVPVPEM
2960 2970 2980 2990 3000
VRDMARIAAL LHRAADLSHV PAMKEIKFLL PKPALGIREI RPAQWVGLVQ
3010 3020 3030 3040 3050
SAWPQVANLS PGQVKAQFLN VLATWPLFGS SFFAVKRIWA EEGPHVEDNH
3060 3070 3080 3090 3100
SPMWRDLILA LNRRGVLFLD PNTHETLQHW SFMEVISTRK VRSEDGALFL
3110 3120 3130 3140
DMKVGNLMQQ RVIRVQTEQA HEISRLVRQY ITMAQISQRD KRELN
Length:3,145
Mass (Da):349,424
Last modified:March 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9AE63FBEF0D8C0A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VZ45Q9VZ45_DROME
Myosin 10A, isoform C
Myo10A 10A, AAF47980, CG16922, CG2136, CG2174
3,054Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PGV5M9PGV5_DROME
Myosin 10A, isoform E
Myo10A 10A, AAF47980, CG16922, CG2136, CG2174
1,069Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ABI30975.2

NCBI Reference Sequences

More...
RefSeqi
NP_001036269.2, NM_001042804.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32028

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG43657

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ABI30975.2
RefSeqiNP_001036269.2, NM_001042804.3

3D structure databases

SMRiQ0KHU0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0302017

Proteomic databases

PaxDbiQ0KHU0
PRIDEiQ0KHU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi32028
KEGGidme:Dmel_CG43657

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32028
FlyBaseiFBgn0263705 Myo10A

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000155335
InParanoidiQ0KHU0
KOiK10361
OrthoDBi14609at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32028

Gene expression databases

BgeeiFBgn0263705 Expressed in 18 organ(s), highest expression level in imaginal disc
ExpressionAtlasiQ0KHU0 differential
GenevisibleiQ0KHU0 DM

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd13201 FERM_C_MyoXV, 1 hit
cd01387 MYSc_Myo15, 1 hit
Gene3Di1.25.40.530, 2 hits
2.30.29.30, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR041795 MyoXV_FERM_C
IPR036057 MYSc_Myo15
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
PfamiView protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ0KHU0_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0KHU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: March 3, 2009
Last modified: September 18, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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