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UniProtKB - Q0KEG0 (Q0KEG0_CUPNH)

Entry version 108 (19 Jan 2022)
Sequence version 1 (03 Oct 2006)
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Protein

3-hydroxyacyl-CoA dehydrogenase

Gene

H16_A0461

Organism
Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseImported
Biological processFatty acid metabolismARBA annotation, Lipid degradationARBA annotation, Lipid metabolism
LigandNADARBA annotation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.1.1.35, 231
4.2.1.17, 231

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00659

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-hydroxyacyl-CoA dehydrogenaseARBA annotation (EC:1.1.1.35ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:H16_A0461Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri381666 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008210 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		381666.H16_A0461

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 1913HCDH_NInterPro annotationAdd BLAST184
Domaini194 – 2933HCDHInterPro annotationAdd BLAST100

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1024, Bacteria
COG1250, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010448_0_0_4

Identification of Orthologs from Complete Genome Data

More...OMAi		GQGFYKK

Database of Orthologous Groups

More...OrthoDBi		82358at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006176, 3-OHacyl-CoA_DH_NAD-bd
IPR006108, 3HC_DH_C
IPR008927, 6-PGluconate_DH-like_C_sf
IPR029045, ClpP/crotonase-like_dom_sf
IPR001753, Enoyl-CoA_hydra/iso
IPR036291, NAD(P)-bd_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00725, 3HCDH, 1 hit
PF02737, 3HCDH_N, 1 hit
PF00378, ECH_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48179, SSF48179, 2 hits
SSF51735, SSF51735, 1 hit
SSF52096, SSF52096, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q0KEG0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNFIVKKVA VLGAGVMGAQ IAAHLINARV PVVLFDLPAK EGPKNGIALR 
        60         70         80         90        100
AIENLKKLSP APLGIKEEAG LIQAANYEDD IALLKECDLV IEAIAERMDW 
       110        120        130        140        150
KHDLYKKVAP HLASHAIFAT NTSGLSITAL SDGFDADLKS RFCGVHFFNP 
       160        170        180        190        200
PRYMHLVELI PTATTQPQIL DQLEAFLTTT LGKGVVRAKD TPNFIANRVG 
       210        220        230        240        250
IFSILAVFAE AEKFGIPFDV VDDLTGSKLG RAKSATFRTA DVVGLDTMAH 
       260        270        280        290        300
VIKTMQDTLH DDPFAPVYKT PAVLKGLVDA GALGQKTGAG FYKKEGKAIK 
       310        320        330        340        350
VLDAKTGQYV DAGKKADEIV VRMLKKDAAE RIKLLRESTN PQAQFLWAVF 
       360        370        380        390        400
RDVFHYIAVY LEQIAGSAAD IDLAIRWGFG WNSGPFEDWQ SAGWKQVAEW 
       410        420        430        440        450
VKEDVEAGKA LSAAPLPAWV FEGPVAENQG VHAAAGSWSP ATQSFVARSK 
       460        470        480        490        500
LPVYQRQAFR AAIKGTAAAD PRKAGRTVEE NDAVRIWVSE GQDDVLVVSF 
       510        520        530        540        550
KSKMNTIGPD VIDGLTRAID LAEAGYKGLV VWQPTSLQLG APGGPFSAGA 
       560        570        580        590        600
NLEAAMPAFM MGGAKGIEPF VKRFQDGMMR VKYASVPVVS AASGIALGGG 
       610        620        630        640        650
CELMLHSASR VAALETYIGL VEVGVGLVPA GGGLKEAALA AARAAQAAGS 
       660        670        680        690        700
TNILQFLTSR FQSAAMAKVS ASALEARQMG YLQPSDKIVF NVHELLYVAQ 
       710        720        730        740        750
NEVRALASAG YRAPLPTLVP VAGRSGIATI KASLVNMRDG GFISTHDFLI 
       760        770        780        790        800
ASRIAEAVCG GDVEAGSLVS EDWLLALERK AFVDLLGTGK TQERIMGMLQ 

TGKPVRN
Length:807
Mass (Da):86,036
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAA03100DD6816A1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AM260479 Genomic DNA Translation: CAJ91611.1

NCBI Reference Sequences

More...RefSeqi		WP_011614529.1, NZ_CP039287.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CAJ91611; CAJ91611; H16_A0461

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57642557

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		reh:H16_A0461

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|381666.6.peg.824

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA Translation: CAJ91611.1
RefSeqiWP_011614529.1, NZ_CP039287.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi381666.H16_A0461

Genome annotation databases

EnsemblBacteriaiCAJ91611; CAJ91611; H16_A0461
GeneIDi57642557
KEGGireh:H16_A0461
PATRICifig|381666.6.peg.824

Phylogenomic databases

eggNOGiCOG1024, Bacteria
COG1250, Bacteria
HOGENOMiCLU_010448_0_0_4
OMAiGQGFYKK
OrthoDBi82358at2

Enzyme and pathway databases

UniPathwayiUPA00659
BRENDAi1.1.1.35, 231
4.2.1.17, 231

Family and domain databases

InterProiView protein in InterPro
IPR006176, 3-OHacyl-CoA_DH_NAD-bd
IPR006108, 3HC_DH_C
IPR008927, 6-PGluconate_DH-like_C_sf
IPR029045, ClpP/crotonase-like_dom_sf
IPR001753, Enoyl-CoA_hydra/iso
IPR036291, NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725, 3HCDH, 1 hit
PF02737, 3HCDH_N, 1 hit
PF00378, ECH_1, 1 hit
SUPFAMiSSF48179, SSF48179, 2 hits
SSF51735, SSF51735, 1 hit
SSF52096, SSF52096, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ0KEG0_CUPNH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0KEG0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: January 19, 2022
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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