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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25GTPUniRule annotation1
Binding sitei53GTPUniRule annotation1
Binding sitei71GTPUniRule annotation1
Metal bindingi101MagnesiumUniRule annotation1
Binding sitei101GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:H16_A2582
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000008210 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000191371 – 199Molybdenum cofactor guanylyltransferaseAdd BLAST199

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi381666.H16_A2582

Structurei

3D structure databases

ProteinModelPortaliQ0K8K6
SMRiQ0K8K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6R Bacteria
COG0746 LUCA
HOGENOMiHOG000280423
KOiK03752
OMAiFVPCDVP

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR02665 molyb_mobA, 1 hit

Sequencei

Sequence statusi: Complete.

Q0K8K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIARDDITGL ILAGGRGSRM GGTDKGLQPL HGTPMAMHTM MRLTPQVGGL
60 70 80 90 100
MINANRNLAA YESFGVPVYT DTVPDFAGPL AGMLAGLEQC ATPWMVTAPC
110 120 130 140 150
DSPFLPTDLV ARLAQAIEAE GADLAIPVTL DEDGRRQTQP VFCLMPVSAL
160 170 180 190
DSLVAYLSGG GRKIETWAAS HRLAEVLFDD AAAFANINTL DELRTHETR
Length:199
Mass (Da):21,196
Last modified:October 3, 2006 - v1
Checksum:i907F52193B738AD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA Translation: CAJ93665.1
RefSeqiWP_010814665.1, NC_008313.1

Genome annotation databases

EnsemblBacteriaiCAJ93665; CAJ93665; H16_A2582
KEGGireh:H16_A2582

Similar proteinsi

Entry informationi

Entry nameiMOBA_CUPNH
AccessioniPrimary (citable) accession number: Q0K8K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: July 18, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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