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UniProtKB - Q0K844 (SAUT_CUPNH)
Protein
Probable sulfoacetate--CoA ligase
Gene
sauT
Organism
Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha)
Status
Functioni
Catalyzes the CoA- and ATP-dependent conversion of sulfoacetate to sulfoacetyl-CoA and AMP.
1 PublicationGO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ligase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ligase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sauT Ordered Locus Names:H16_A2748 |
Organismi | Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) |
Taxonomic identifieri | 381666 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
Mutants do not grow with sulfoacetate, but can use acetate, taurine, isethionate and sulfoacetaldehyde.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000418823 | 1 – 509 | Probable sulfoacetate--CoA ligaseAdd BLAST | 509 |
Expressioni
Inductioni
Induced by sulfoacetate.1 Publication
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 320 – 340 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Phylogenomic databases
eggNOGi | COG0318, Bacteria |
HOGENOMi | CLU_000022_59_10_4 |
OMAi | VPTMWIA |
OrthoDBi | 961884at2 |
Family and domain databases
CDDi | cd05926, FACL_fum10p_like, 1 hit |
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR045310, Pcs60-like |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0K844-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNARTEPEVF DTLAALIAVR AAQWPDKPYL LSPDSGHALT FGALATDAGT
60 70 80 90 100
LGRSYAAAGL GSGQTVSVYL PNGEQTARLL LGTMACGLVV NPINLLCQPA
110 120 130 140 150
QLRYILAHSD TRLVFTWPDG EAAIREALRE AGLDVPVLVT APDANSLPAL
160 170 180 190 200
PATHDAASPL PPPQPDAPAL LMYTSGTTGT PKGVLLTQRN LVANGTNVSR
210 220 230 240 250
EHCLGPADRV LATLPLYHIN GLVVTAIAPL VHGGSVVMPM RFSASAFWQD
260 270 280 290 300
SARHGCTWLN VVPTIIAYLL NDPHGQAPAG VRFCRSASAA LPPEHHRAFE
310 320 330 340 350
ARFGIGVIET MGMTETAAPA FSNPLDPGQR RIGSIGRPSG TRARVLGRDG
360 370 380 390 400
KPAPDGQVGE IVLQGESVMA GYYKAPDITR EAFTHDGWLR TGDLGYRDAD
410 420 430 440 450
GYFYISGRAK ELIIKGGENI APREIDEALL RHPGVLEAAA VGVPDPAYGQ
460 470 480 490 500
EIVAYVVMRE AARCDDAALR AHCLRELGRY KTPKEFRFIA ELPRGPSGKV
QRLKLLNHA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM260479 Genomic DNA Translation: CAJ93827.1 |
RefSeqi | WP_011615810.1, NZ_CP039287.1 |
Genome annotation databases
EnsemblBacteriai | CAJ93827; CAJ93827; H16_A2748 |
GeneIDi | 57644872 |
KEGGi | reh:H16_A2748 |
PATRICi | fig|381666.6.peg.3144 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM260479 Genomic DNA Translation: CAJ93827.1 |
RefSeqi | WP_011615810.1, NZ_CP039287.1 |
3D structure databases
AlphaFoldDBi | Q0K844 |
SMRi | Q0K844 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 381666.H16_A2748 |
Genome annotation databases
EnsemblBacteriai | CAJ93827; CAJ93827; H16_A2748 |
GeneIDi | 57644872 |
KEGGi | reh:H16_A2748 |
PATRICi | fig|381666.6.peg.3144 |
Phylogenomic databases
eggNOGi | COG0318, Bacteria |
HOGENOMi | CLU_000022_59_10_4 |
OMAi | VPTMWIA |
OrthoDBi | 961884at2 |
Family and domain databases
CDDi | cd05926, FACL_fum10p_like, 1 hit |
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR045310, Pcs60-like |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SAUT_CUPNH | |
Accessioni | Q0K844Primary (citable) accession number: Q0K844 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2012 |
Last sequence update: | October 3, 2006 | |
Last modified: | May 25, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families