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Protein

Alcohol dehydrogenase 2

Gene

ADH2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Binding sitei69SubstrateBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1
Binding sitei226NADBy similarity1
Binding sitei231NADBy similarity1
Binding sitei272NAD; via carbonyl oxygenBy similarity1
Binding sitei295NAD; via carbonyl oxygenBy similarity1
Binding sitei322NAD; via amide nitrogenBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 207NADBy similarity6
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-OSA-2161541 Abacavir metabolism
R-OSA-5365859 RA biosynthesis pathway
R-OSA-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH2
Synonyms:DUPR11.1
Ordered Locus Names:Os11g0210500, LOC_Os11g10510
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607081 – 379Alcohol dehydrogenase 2Add BLAST379

Proteomic databases

PaxDbiQ0ITW7
PRIDEiQ0ITW7

Expressioni

Gene expression databases

ExpressionAtlasiQ0ITW7 differential
GenevisibleiQ0ITW7 OS

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os11g10510.1

Structurei

3D structure databases

ProteinModelPortaliQ0ITW7
SMRiQ0ITW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
InParanoidiQ0ITW7
KOiK18857
OMAiYGGMNPR
OrthoDBiEOG09360BVQ

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q0ITW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILYTALCHTD
60 70 80 90 100
VYFWEAKGQT PVFPRILGHE AGGIVESVGE GVTELAPGDH VLPVFTGECK
110 120 130 140 150
ECDHCKSEES NMCDLLRINV DRGVMIGDGK SRFTIKGKPI FHFVGTSTFS
160 170 180 190 200
EYTVIHVGCL AKINPEAPLD KVCILSCGFS TGFGATVNVA KPKKGQTVAI
210 220 230 240 250
FGLGAVGLAA MEGARLSGAS RIIGVDLNPA KFEQAKKFGC TDFVNPKDHS
260 270 280 290 300
KPVHEVLIEM TNGGLDRAVE CTGNINAMIS CFECVHDGWG VAVLVGVPTK
310 320 330 340 350
DDVFKTHPMN FLNEKTLKGT FFGNYKPRTD LPNVVELYMK KELELEKFIT
360 370
HSVPFSEINT AFDLMLKGES LRCVMRMDE
Length:379
Mass (Da):41,207
Last modified:June 12, 2007 - v2
Checksum:i2DF98CF6B6BEE8EA
GO

Sequence cautioni

The sequence AK102799 differs from that shown. Reason: Frameshift at position 369.Curated
The sequence BAF27848 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42L → I in AK102799 (PubMed:12869764).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172282 Genomic DNA Translation: AAF34412.1
DP000010 Genomic DNA Translation: ABA92034.1
AP008217 Genomic DNA Translation: BAF27848.1 Sequence problems.
AP014967 Genomic DNA Translation: BAT13176.1
AK102799 mRNA No translation available.
RefSeqiXP_015616854.1, XM_015761368.1
UniGeneiOs.8815

Genome annotation databases

EnsemblPlantsiOs11t0210500-01; Os11t0210500-01; Os11g0210500
GeneIDi4350054
GrameneiOs11t0210500-01; Os11t0210500-01; Os11g0210500
KEGGiosa:4350054

Similar proteinsi

Entry informationi

Entry nameiADH2_ORYSJ
AccessioniPrimary (citable) accession number: Q0ITW7
Secondary accession number(s): P18332, Q2R8Z2, Q9LLQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

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