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UniProtKB - Q0IJ08 (DYR1A_XENTR)
Protein
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Gene
dyrk1a
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates (By similarity).
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 180 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 279 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 157 – 165 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 230 – 233 | ATPPROSITE-ProRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: UniProtKB
- transcription coactivator activity Source: GO_Central
GO - Biological processi
- peptidyl-serine phosphorylation Source: GO_Central
- peptidyl-threonine phosphorylation Source: GO_Central
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: GO_Central
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-XTR-1538133, G0 and Early G1 |
Names & Taxonomyi
Protein namesi | Recommended name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC:2.7.12.1)Alternative name(s): Protein kinase minibrain homolog |
Gene namesi | |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-1017105, dyrk1a |
Subcellular locationi
Nucleus
- Nucleus speckle By similarity
Nucleus
- nuclear speck Source: UniProtKB
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284708 | 1 – 751 | Dual specificity tyrosine-phosphorylation-regulated kinase 1AAdd BLAST | 751 |
Post-translational modificationi
Autophosphorylated on tyrosine residues.By similarity
Keywords - PTMi
PhosphoproteinFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 151 – 471 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 321 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 59 – 81 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 104 – 129 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 477 – 532 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 580 – 667 | DisorderedSequence analysisAdd BLAST | 88 | |
Regioni | 730 – 751 | DisorderedSequence analysisAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 109 – 126 | Bipartite nuclear localization signalSequence analysisAdd BLAST | 18 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 59 – 76 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 477 – 520 | Polar residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 592 – 613 | Basic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 614 – 667 | Polar residuesSequence analysisAdd BLAST | 54 |
Domaini
The polyhistidine repeats act as targeting signals to nuclear speckles.By similarity
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.Curated
Phylogenomic databases
InParanoidi | Q0IJ08 |
OMAi | YLVEETW |
OrthoDBi | 689446at2759 |
Family and domain databases
CDDi | cd14226, PKc_DYRK1, 1 hit |
InterProi | View protein in InterPro IPR028318, DYRK1A/B_MNB IPR011009, Kinase-like_dom_sf IPR044131, PKc_DYR1A/1B IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24058:SF121, PTHR24058:SF121, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0IJ08-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMSHSHQQ YSDRRQQNLN
60 70 80 90 100
DQQASALPYN DQIQQPLPNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN
110 120 130 140 150
EVYYAKKKRR HQQGQGDDSS HKKERKVYND GYDDDNYDYI VKNGEKWMDR
160 170 180 190 200
YEIDSLIGKG SFGQVVKAYD RAEQEWVAIK IIKNKKAFLN QAQIEVRLLE
210 220 230 240 250
LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS
260 270 280 290 300
LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF
310 320 330 340 350
GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY DLAIDMWSLG CILVEMHTGE
360 370 380 390 400
PLFSGANEVD QMSKIVEVLG IPPAHILDQA PKARKFFEKM PEGTWNLKKT
410 420 430 440 450
KDGKKEYKPP GTRKLHNLLG VETGGPGGRR GGESGHTVAD YLKFKDLILR
460 470 480 490 500
MLDYDAKTRI QPYYALQHSF FKKTADEGTN TSNSVSTSPA MEQSQSSGTT
510 520 530 540 550
SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA MDCETHSPQV
560 570 580 590 600
RQQFPPGWTV PEAPTQVTIE THPVQETTFH VPSSQQNVPH HHGNGSHHHH
610 620 630 640 650
HHHHHHHGQH VLSNRTRTRI YNSPSTSSST QDSMDVGHSH HSMTSLSSST
660 670 680 690 700
TSSSTSSSST GNQGNQAYQN RPVAANTLDF GQNGTMDVNL TAFSNPRQET
710 720 730 740 750
GITGHPDYQY SANTGPGHYV TEGHLTMRQG MDREDSPMTG VCVQQSPVAS
S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC121291 mRNA Translation: AAI21292.1 |
RefSeqi | NP_001072280.1, NM_001078812.1 |
Genome annotation databases
GeneIDi | 779733 |
KEGGi | xtr:779733 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC121291 mRNA Translation: AAI21292.1 |
RefSeqi | NP_001072280.1, NM_001078812.1 |
3D structure databases
SMRi | Q0IJ08 |
ModBasei | Search... |
Protocols and materials databases
DNASUi | 779733 |
Genome annotation databases
GeneIDi | 779733 |
KEGGi | xtr:779733 |
Organism-specific databases
CTDi | 1859 |
Xenbasei | XB-GENE-1017105, dyrk1a |
Phylogenomic databases
InParanoidi | Q0IJ08 |
OMAi | YLVEETW |
OrthoDBi | 689446at2759 |
Enzyme and pathway databases
Reactomei | R-XTR-1538133, G0 and Early G1 |
Family and domain databases
CDDi | cd14226, PKc_DYRK1, 1 hit |
InterProi | View protein in InterPro IPR028318, DYRK1A/B_MNB IPR011009, Kinase-like_dom_sf IPR044131, PKc_DYR1A/1B IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24058:SF121, PTHR24058:SF121, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DYR1A_XENTR | |
Accessioni | Q0IJ08Primary (citable) accession number: Q0IJ08 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | October 3, 2006 | |
Last modified: | February 23, 2022 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families