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Protein
Submitted name:

Keratin 77

Gene

KRT77

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Keratin 77Imported
Gene namesi
Name:KRT77Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filamentPROSITE-ProRule annotationSAAS annotation, KeratinImported

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896049

PTM / Processingi

Proteomic databases

PeptideAtlasiQ0IIN1
PRIDEiQ0IIN1

Expressioni

Gene expression databases

GenevisibleiQ0IIN1 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

IntActiQ0IIN1, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ0IIN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 477IF rodInterPro annotationAdd BLAST314

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili375 – 452Sequence analysisAdd BLAST78

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IVT1 Eukaryota
ENOG4111ACY LUCA
HOVERGENiHBG013015
KOiK07605

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0IIN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHQFSSQSA FSSMSRRVYS TSSSAGSGGG SPAVGSVCYA RGRCGGGGYG
60 70 80 90 100
IHGRGFGSRS LYNLGGSRSI SINLMGRSTS GFCQGGGVGG FGGGRGFGVG
110 120 130 140 150
STGAGGFGGG GFGGAGFGTS NFGLGGFGPY CPPGGIQEVT INQSLLEPLH
160 170 180 190 200
LEVDPEIQRI KTQEREQIMV LNNKFASFID KVRFLEQQNQ VLQTKWELLQ
210 220 230 240 250
QVNTSTGTNN LEPLLENYIG DLRRQVDLLS AEQMRQNAEV RSMQDVVEDY
260 270 280 290 300
KSKYEDEINK RTGSENDFVV LKKDVDAAYV SKVDLESRVD TLTGEVNFLK
310 320 330 340 350
YLFLTELSQV QTHISDTNVI LSMDNNRSLD LDSIIDAVRT QYELIAQRSK
360 370 380 390 400
DEAEALYQTK YQELQITAGR HGDDLKNSKM EIAELNRTVQ RLQAEISNVK
410 420 430 440 450
KQIEQMQSLI SDAEERGEQA LQDAWQKLQD LEEALQQSKE ELARLLRDYQ
460 470 480 490 500
AMLGVKLSLD VEIATYRQLL EGEESRMSGE LQSHVSISVQ NSQVSVNGGA
510 520 530 540 550
GGGGSYGSGG YGGGSGGGYG GGRSYRGGGA RGGSGGGYGS GCGGGGGSYG
560 570
GSGRSGRGSS RVQIIQTSTN TSHRRILE
Length:578
Mass (Da):61,802
Last modified:October 3, 2006 - v1
Checksum:i399F92351DE1FDCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122558 mRNA Translation: AAI22559.1
RefSeqiNP_778253.2, NM_175078.2
UniGeneiHs.334989

Genome annotation databases

GeneIDi374454
KEGGihsa:374454

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122558 mRNA Translation: AAI22559.1
RefSeqiNP_778253.2, NM_175078.2
UniGeneiHs.334989

3D structure databases

ProteinModelPortaliQ0IIN1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0IIN1, 3 interactors

Proteomic databases

PeptideAtlasiQ0IIN1
PRIDEiQ0IIN1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374454
KEGGihsa:374454

Organism-specific databases

CTDi374454
PharmGKBiPA134896049

Phylogenomic databases

eggNOGiENOG410IVT1 Eukaryota
ENOG4111ACY LUCA
HOVERGENiHBG013015
KOiK07605

Miscellaneous databases

GenomeRNAii374454

Gene expression databases

GenevisibleiQ0IIN1 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ0IIN1_HUMAN
AccessioniPrimary (citable) accession number: Q0IIN1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 20, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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