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Protein

TBC1 domain family member 8B

Gene

TBC1D8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei534Arginine fingerBy similarity1
Sitei573Glutamine fingerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 8B
Gene namesi
Name:TBC1D8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000133138.19
HGNCiHGNC:24715 TBC1D8B
neXtProtiNX_Q0IIM8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133138
PharmGKBiPA145148061

Polymorphism and mutation databases

BioMutaiTBC1D8B
DMDMi189029914

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371831 – 1120TBC1 domain family member 8BAdd BLAST1120

Proteomic databases

EPDiQ0IIM8
MaxQBiQ0IIM8
PaxDbiQ0IIM8
PeptideAtlasiQ0IIM8
PRIDEiQ0IIM8
ProteomicsDBi58757
58758 [Q0IIM8-2]
58759 [Q0IIM8-3]

PTM databases

iPTMnetiQ0IIM8
PhosphoSitePlusiQ0IIM8

Expressioni

Gene expression databases

BgeeiENSG00000133138
CleanExiHS_TBC1D8B
ExpressionAtlasiQ0IIM8 baseline and differential
GenevisibleiQ0IIM8 HS

Organism-specific databases

HPAiHPA023883
HPA027527

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ0IIM8, 1 interactor
STRINGi9606.ENSP00000349781

Structurei

3D structure databases

ProteinModelPortaliQ0IIM8
SMRiQ0IIM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 212GRAM 1Add BLAST68
Domaini285 – 353GRAM 2Add BLAST69
Domaini487 – 674Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST188
Domaini858 – 893EF-handPROSITE-ProRule annotationAdd BLAST36

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00760000119137
HOGENOMiHOG000201207
HOVERGENiHBG054142
InParanoidiQ0IIM8
KOiK19951
OMAiEITKHWD
OrthoDBiEOG091G00RI
PhylomeDBiQ0IIM8
TreeFamiTF313145

Family and domain databases

CDDicd13350 PH-GRAM1_TBC1D8B, 1 hit
cd13352 PH-GRAM2_TBC1D8B, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036012 TBC1D8B_PH-GRAM1
IPR036015 TBC1D8B_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0IIM8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLKPEEVLL KNALKLWLME RSNDYFVLQR RRGYGEEGGG GLTGLLVGTL
60 70 80 90 100
DSVLDSTAKV APFRILHQTP DSQVYLSIAC GANREEITKH WDWLEQNIMK
110 120 130 140 150
TLSVFDSNED ITNFVQGKIR GLIAEEGKHC FAKEDDPEKF REALLKFEKC
160 170 180 190 200
FGLPEKEKLV TYYSCSYWKG RVPCQGWLYL STNFLSFYSF LLGSEIKLII
210 220 230 240 250
SWDEVSKLEK TSNVILTESI HVCSQGENHY FSMFLHINQT YLLMEQLANY
260 270 280 290 300
AIRRLFDKET FDNDPVLYNP LQITKRGLEN RAHSEQFNAF FRLPKGESLK
310 320 330 340 350
EVHECFLWVP FSHFNTHGKM CISENYICFA SQDGNQCSVI IPLREVLAID
360 370 380 390 400
KTNDSSKSVI ISIKGKTAFR FHEVKDFEQL VAKLRLRCGA ASTQYHDIST
410 420 430 440 450
ELAISSESTE PSDNFEVQSL TSQRECSKTV NTEALMTVFH PQNLETLNSK
460 470 480 490 500
MLKEKMKEQS WKILFAECGR GVSMFRTKKT RDLVVRGIPE TLRGELWMLF
510 520 530 540 550
SGAVNDMATN PDYYTEVVEQ SLGTCNLATE EIERDLRRSL PEHPAFQSDT
560 570 580 590 600
GISALRRVLT AYAYRNPKIG YCQAMNILTS VLLLYAKEEE AFWLLVAVCE
610 620 630 640 650
RMLPDYFNRR IIGALVDQAV FEELIRDHLP QLTEHMTDMT FFSSVSLSWF
660 670 680 690 700
LTLFISVLPI ESAVNVVDCF FYDGIKAILQ LGLAILDYNL DKLLTCKDDA
710 720 730 740 750
EAVTALNRFF DNVTNKDSPL PSNVQQGSNV SDEKTSHTRV DITDLIRESN
760 770 780 790 800
EKYGNIRYED IHSMRCRNRL YVIQTLEETT KQNVLRVVSQ DVKLSLQELD
810 820 830 840 850
ELYVIFKKEL FLSCYWCLGC PVLKHHDPSL PYLEQYQIDC QQFRALYHLL
860 870 880 890 900
SPWAHSANKD SLALWTFRLL DENSDCLINF KEFSSAIDIM YNGSFTEKLK
910 920 930 940 950
LLFKLHIPPA YTEVKSKDAS KGDELSKEEL LYFSQLHVSK PANEKEAESA
960 970 980 990 1000
KHSPEKGKGK IDIQAYLSQW QDELFKKEEN IKDLPRMNQS QFIQFSKTLY
1010 1020 1030 1040 1050
NLFHEDPEEE SLYQAIAVVT SLLLRMEEVG RKLHSPTSSA KGFSGTVCGS
1060 1070 1080 1090 1100
GGPSEEKTGS HLEKDPCSFR EEPQWSFAFE QILASLLNEP ALVRFFEKPI
1110 1120
DVKAKLENAR ISQLRSRTKM
Length:1,120
Mass (Da):128,709
Last modified:May 20, 2008 - v2
Checksum:i3629EF0AE95E7A96
GO
Isoform 2 (identifier: Q0IIM8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     614-632: ALVDQAVFEELIRDHLPQL → SDDFMPLVRIQGQCVIG
     633-1120: Missing.

Show »
Length:630
Mass (Da):72,366
Checksum:i61D2BEA7369CA101
GO
Isoform 3 (identifier: Q0IIM8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     614-632: ALVDQAVFEELIRDHLPQL → SDDFMPLVRIQGQCVIGEK
     633-1120: Missing.

Show »
Length:632
Mass (Da):72,623
Checksum:i8C8AA1D2BEA7369C
GO

Sequence cautioni

The sequence BAA91071 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti503A → V in BAC85735 (PubMed:14702039).Curated1
Sequence conflicti891Y → C in BAA91071 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033953614 – 632ALVDQ…HLPQL → SDDFMPLVRIQGQCVIG in isoform 2. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_043710614 – 632ALVDQ…HLPQL → SDDFMPLVRIQGQCVIGEK in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_033954633 – 1120Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST488

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449890 mRNA Translation: BAH16633.1
AB449891 mRNA Translation: BAH16634.1
AK000305 mRNA Translation: BAA91071.1 Different initiation.
AK123957 mRNA Translation: BAC85735.1
AL391315 Genomic DNA No translation available.
AL591849 Genomic DNA No translation available.
BC122564 mRNA Translation: AAI22565.1
CCDSiCCDS14522.1 [Q0IIM8-1]
CCDS14523.1 [Q0IIM8-3]
RefSeqiNP_060222.2, NM_017752.2 [Q0IIM8-1]
NP_942582.1, NM_198881.1 [Q0IIM8-3]
UniGeneiHs.351798

Genome annotation databases

EnsembliENST00000310452; ENSP00000310675; ENSG00000133138 [Q0IIM8-3]
ENST00000357242; ENSP00000349781; ENSG00000133138 [Q0IIM8-1]
GeneIDi54885
KEGGihsa:54885
UCSCiuc004emn.5 human [Q0IIM8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTBC8B_HUMAN
AccessioniPrimary (citable) accession number: Q0IIM8
Secondary accession number(s): B9A6K5
, B9A6K6, Q5JRB7, Q6ZVX5, Q9NXE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 18, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM

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