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Protein

Translation initiation factor eIF-2B subunit alpha

Gene

EIF2B1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit alpha
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit alpha
Gene namesi
Name:EIF2B1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:28384 EIF2B1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830621 – 305Translation initiation factor eIF-2B subunit alphaAdd BLAST305

Proteomic databases

PaxDbiQ0IIF2
PRIDEiQ0IIF2

Expressioni

Gene expression databases

BgeeiENSBTAG00000007269

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009560

Structurei

3D structure databases

ProteinModelPortaliQ0IIF2
SMRiQ0IIF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1466 Eukaryota
COG1184 LUCA
GeneTreeiENSGT00550000074853
HOGENOMiHOG000175731
HOVERGENiHBG051457
InParanoidiQ0IIF2
KOiK03239
OMAiQYLVGMF
OrthoDBiEOG091G0CQR
TreeFamiTF101505

Family and domain databases

InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit

Sequencei

Sequence statusi: Complete.

Q0IIF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNTELIEYF KSQIKEDPDM ASAVAAIRTL LEYLRRDTGE TIQGLRANLT
60 70 80 90 100
SAIETLCGVD SSVAVSSGGE LFLRFISLTS LEYSDYSKCK KIMIERGEIF
110 120 130 140 150
LRRISLSRNK IADLCHTFIK DGARILTHAY SRVVLRVLEA AVAAKKRFSV
160 170 180 190 200
YITESQPDLS GKKMAKALCH LNVPVTVVLD AAVGYIMEKV DLVIVGAEGV
210 220 230 240 250
VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQQDVPDKF
260 270 280 290 300
KYKADTLKSV QTGQDLREEH PWVDYTSPSL ITLLFTDLGV LTPSAVSDEL

IKLYL
Length:305
Mass (Da):33,870
Last modified:October 3, 2006 - v1
Checksum:i22FFC8682F72CB55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122673 mRNA Translation: AAI22674.1
RefSeqiNP_001069211.1, NM_001075743.1
UniGeneiBt.52306

Genome annotation databases

EnsembliENSBTAT00000009560; ENSBTAP00000009560; ENSBTAG00000007269
GeneIDi516670
KEGGibta:516670

Similar proteinsi

Entry informationi

Entry nameiEI2BA_BOVIN
AccessioniPrimary (citable) accession number: Q0IIF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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