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Entry version 99 (08 May 2019)
Sequence version 1 (03 Oct 2006)
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Protein

SHC-transforming protein 1

Gene

SHC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Growth regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-1250196 SHC1 events in ERBB2 signaling
R-BTA-1250347 SHC1 events in ERBB4 signaling
R-BTA-167044 Signalling to RAS
R-BTA-180336 SHC1 events in EGFR signaling
R-BTA-210993 Tie2 Signaling
R-BTA-2424491 DAP12 signaling
R-BTA-2428933 SHC-related events triggered by IGF1R
R-BTA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-BTA-2871796 FCERI mediated MAPK activation
R-BTA-2871809 FCERI mediated Ca+2 mobilization
R-BTA-354192 Integrin alphaIIb beta3 signaling
R-BTA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-BTA-5654688 SHC-mediated cascade:FGFR1
R-BTA-5654699 SHC-mediated cascade:FGFR2
R-BTA-5654704 SHC-mediated cascade:FGFR3
R-BTA-5654719 SHC-mediated cascade:FGFR4
R-BTA-5673001 RAF/MAP kinase cascade
R-BTA-74749 Signal attenuation
R-BTA-74751 Insulin receptor signalling cascade
R-BTA-8853659 RET signaling
R-BTA-8983432 Interleukin-15 signaling
R-BTA-9020558 Interleukin-2 signaling
R-BTA-912526 Interleukin receptor SHC signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SHC-transforming protein 1
Alternative name(s):
Src homology 2 domain-containing-transforming protein C1
Short name:
SH2 domain protein C1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:34590 SHC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003272201 – 473SHC-transforming protein 1Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29PhosphoserineBy similarity1
Modified residuei44N6-acetyllysineBy similarity1
Modified residuei239PhosphotyrosineBy similarity1
Modified residuei240PhosphotyrosineBy similarity1
Modified residuei317PhosphotyrosineBy similarity1
Modified residuei343PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Tyrosine phosphorylated in response to FLT3 and FLT4 signaling and by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1. Tyrosine phosphorylated by activated PTK2B/PYK2. Dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0IIE2

PRoteomics IDEntifications database

More...
PRIDEi
Q0IIE2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000019838 Expressed in 9 organ(s), highest expression level in colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0IIE2 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPNE3; this interaction may mediate the binding of CPNE3 with ERBB2 (By similarity).

Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner.

Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2.

Interacts with tyrosine-phosphorylated CD3T and DDR2.

Interacts with the N-terminal region of APS.

Interacts with phosphorylated LRP1 and IRS4.

Interacts with INPP5D/SHIP1 and INPPL1/SHIP2.

Interacts with ALK, GAB2, GRB7 and KIT.

Interacts with PTPN6/SHP (tyrosine phosphorylated).

Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN.

Interacts with FLT4 (tyrosine-phosphorylated).

Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration.

Interacts with PDGFRB (tyrosine-phosphorylated).

Interacts with ERBB4.

Interacts with TEK/TIE2 (tyrosine-phosphorylated).

Interacts with PTK2/FAK1 (By similarity).

Interacts with CEACAM1; this interaction is CEACAM1-phosphorylation-dependent and mediates interaction with EGFR or INSR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity).

Interacts (via PID domain) with PEAK1 (when phosphorylated) (By similarity).

Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000026432

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0IIE2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 229PIDPROSITE-ProRule annotationAdd BLAST184
Domaini378 – 469SH2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni230 – 377CH1Add BLAST148

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 9Poly-Gly4
Compositional biasi301 – 364Pro-richAdd BLAST64

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3697 Eukaryota
ENOG410XTJN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182870

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231974

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0IIE2

KEGG Orthology (KO)

More...
KOi
K06279

Database of Orthologous Groups

More...
OrthoDBi
1351843at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029586 Shc1/ShcA
IPR035676 SHC_SH2

The PANTHER Classification System

More...
PANTHERi
PTHR10337:SF2 PTHR10337:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q0IIE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV
60 70 80 90 100
SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK
110 120 130 140 150
PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ IIANHHMQSI
160 170 180 190 200
SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV ISTIGQAFEL
210 220 230 240 250
RFKQYLRNPP RLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL
260 270 280 290 300
GGVVDMRLRE GALPGAARPT PPSAQTPSHL GATLPVGQPA GGDPEARRQM
310 320 330 340 350
PPPPPSSGRE LFDDPSYVNV QNLDKARQAG AGAGPPNPTI NGSAPRDLFD
360 370 380 390 400
MKPFEDALRM PPPPQSTAMA EQLRGEPWFH GKLSRREAEA LLQVNGDFLV
410 420 430 440 450
RESTTTPGQY VLTGLQSGQP KHLLLVDPEG VVRTKDHRFE SVSHLISYHM
460 470
DNHLPIISAG SELCLQQPVE RKL
Length:473
Mass (Da):51,631
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2B0277087268CDF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1B716E1B716_BOVIN
SHC-transforming protein 1
SHC1
583Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2 – 3NK → HN in AAZ38953 (Ref. 2) Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC122688 mRNA Translation: AAI22689.1
DQ125497 mRNA Translation: AAZ38953.1

NCBI Reference Sequences

More...
RefSeqi
NP_001068773.1, NM_001075305.2
NP_001157533.1, NM_001164061.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000040264; ENSBTAP00000040041; ENSBTAG00000019838
ENSBTAT00000075224; ENSBTAP00000062285; ENSBTAG00000019838

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
507196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:507196

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122688 mRNA Translation: AAI22689.1
DQ125497 mRNA Translation: AAZ38953.1
RefSeqiNP_001068773.1, NM_001075305.2
NP_001157533.1, NM_001164061.1

3D structure databases

SMRiQ0IIE2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026432

Proteomic databases

PaxDbiQ0IIE2
PRIDEiQ0IIE2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000040264; ENSBTAP00000040041; ENSBTAG00000019838
ENSBTAT00000075224; ENSBTAP00000062285; ENSBTAG00000019838
GeneIDi507196
KEGGibta:507196

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6464
VGNCiVGNC:34590 SHC1

Phylogenomic databases

eggNOGiKOG3697 Eukaryota
ENOG410XTJN LUCA
GeneTreeiENSGT00950000182870
HOGENOMiHOG000231974
InParanoidiQ0IIE2
KOiK06279
OrthoDBi1351843at2759

Enzyme and pathway databases

ReactomeiR-BTA-1250196 SHC1 events in ERBB2 signaling
R-BTA-1250347 SHC1 events in ERBB4 signaling
R-BTA-167044 Signalling to RAS
R-BTA-180336 SHC1 events in EGFR signaling
R-BTA-210993 Tie2 Signaling
R-BTA-2424491 DAP12 signaling
R-BTA-2428933 SHC-related events triggered by IGF1R
R-BTA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-BTA-2871796 FCERI mediated MAPK activation
R-BTA-2871809 FCERI mediated Ca+2 mobilization
R-BTA-354192 Integrin alphaIIb beta3 signaling
R-BTA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-BTA-5654688 SHC-mediated cascade:FGFR1
R-BTA-5654699 SHC-mediated cascade:FGFR2
R-BTA-5654704 SHC-mediated cascade:FGFR3
R-BTA-5654719 SHC-mediated cascade:FGFR4
R-BTA-5673001 RAF/MAP kinase cascade
R-BTA-74749 Signal attenuation
R-BTA-74751 Insulin receptor signalling cascade
R-BTA-8853659 RET signaling
R-BTA-8983432 Interleukin-15 signaling
R-BTA-9020558 Interleukin-2 signaling
R-BTA-912526 Interleukin receptor SHC signaling

Gene expression databases

BgeeiENSBTAG00000019838 Expressed in 9 organ(s), highest expression level in colon
ExpressionAtlasiQ0IIE2 baseline and differential

Family and domain databases

CDDicd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029586 Shc1/ShcA
IPR035676 SHC_SH2
PANTHERiPTHR10337:SF2 PTHR10337:SF2, 1 hit
PfamiView protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHC1_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0IIE2
Secondary accession number(s): Q45KX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 3, 2006
Last modified: May 8, 2019
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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