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Protein

Ribonuclease P protein subunit p20

Gene

POP7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p20 (EC:3.1.26.5)
Short name:
RNaseP protein p20
Gene namesi
Name:POP7
Synonyms:RPP20
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:33166 POP7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710341 – 140Ribonuclease P protein subunit p20Add BLAST140

Proteomic databases

PaxDbiQ0II25
PRIDEiQ0II25

Expressioni

Gene expression databases

BgeeiENSBTAG00000026248 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000037068

Structurei

3D structure databases

ProteinModelPortaliQ0II25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiENOG410IXMT Eukaryota
ENOG4111R36 LUCA
GeneTreeiENSGT00510000048483
HOGENOMiHOG000253010
HOVERGENiHBG001490
InParanoidiQ0II25
KOiK14527
OMAiGQNACTE
OrthoDBiEOG091G0Y8P
TreeFamiTF313948

Family and domain databases

Gene3Di3.30.110.20, 1 hit
InterProiView protein in InterPro
IPR036882 Alba-like_dom_sf
IPR014612 Pop7/Rpp20
PANTHERiPTHR15314 PTHR15314, 1 hit
PfamiView protein in Pfam
PF12328 Rpp20, 1 hit
PIRSFiPIRSF036572 RPP20, 1 hit
SUPFAMiSSF82704 SSF82704, 1 hit

Sequencei

Sequence statusi: Complete.

Q0II25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENRESRGT VEAELDPVEY TLRKRLPHRL PRRPNDIYVN MKTDFKAQLA
60 70 80 90 100
RCQKLLDGGA RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA
110 120 130 140
NTSTVELVDE LEPETDSREP LTRIRNNSAI HIRVFRVTPK
Length:140
Mass (Da):15,707
Last modified:October 3, 2006 - v1
Checksum:i7E4E130FF44B6BB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122839 mRNA Translation: AAI22840.1
RefSeqiNP_001069950.1, NM_001076482.2
XP_005225275.1, XM_005225218.1
XP_005225276.1, XM_005225219.1
XP_015315985.1, XM_015460499.1
UniGeneiBt.22841

Genome annotation databases

EnsembliENSBTAT00000037231; ENSBTAP00000037068; ENSBTAG00000026248
GeneIDi617906
KEGGibta:617906

Similar proteinsi

Entry informationi

Entry nameiPOP7_BOVIN
AccessioniPrimary (citable) accession number: Q0II25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 3, 2006
Last modified: September 12, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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