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UniProtKB - Q0IHV1 (INF2_XENTR)
Protein
Inverted formin-2
Gene
inf2
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- small GTPase binding Source: InterPro
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Inverted formin-2 |
Gene namesi | Name:inf2 |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-5862185, inf2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000259892 | 1 – 1380 | Inverted formin-2Add BLAST | 1380 |
Proteomic databases
PaxDbi | Q0IHV1 |
PRIDEi | Q0IHV1 |
Expressioni
Gene expression databases
Bgeei | ENSXETG00000008613, Expressed in female gonad and 11 other tissues |
Interactioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- small GTPase binding Source: InterPro
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000018819 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 330 | GBD/FH3PROSITE-ProRule annotationAdd BLAST | 330 | |
Domaini | 432 – 592 | FH1Add BLAST | 161 | |
Domaini | 593 – 981 | FH2PROSITE-ProRule annotationAdd BLAST | 389 | |
Domaini | 1009 – 1024 | WH2PROSITE-ProRule annotationAdd BLAST | 16 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 341 – 391 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 440 – 541 | DisorderedSequence analysisAdd BLAST | 102 | |
Regioni | 1026 – 1049 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1188 – 1244 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 1260 – 1380 | DisorderedSequence analysisAdd BLAST | 121 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 879 – 930 | Sequence analysisAdd BLAST | 52 | |
Coiled coili | 956 – 991 | Sequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 367 – 384 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 445 – 541 | Pro residuesSequence analysisAdd BLAST | 97 | |
Compositional biasi | 1203 – 1244 | Polar residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 1260 – 1300 | Polar residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 1301 – 1320 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1323 – 1343 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the formin homology family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1922, Eukaryota |
HOGENOMi | CLU_005383_1_0_1 |
InParanoidi | Q0IHV1 |
OMAi | DHYKMVC |
OrthoDBi | 1204639at2759 |
PhylomeDBi | Q0IHV1 |
TreeFami | TF326300 |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR014768, GBD/FH3_dom IPR010473, GTPase-bd IPR027649, Inf2 IPR003124, WH2_dom |
PANTHERi | PTHR46345, PTHR46345, 2 hits |
Pfami | View protein in Pfam PF06367, Drf_FH3, 1 hit PF06371, Drf_GBD, 1 hit PF02181, FH2, 1 hit PF02205, WH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM01140, Drf_GBD, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit PS51082, WH2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q0IHV1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLKEGAHTK WGVLKQKLGP QDPEQIEGNM ENADPELCIR LLQIPSVVNY
60 70 80 90 100
SGLKKRLESS DDDWMVQFLE LSGLDLLLEA LDRLSGRGVA RIADALLQLT
110 120 130 140 150
CINCVRTLMN SHRGIEYIVN NEGYVRKLSQ ALDTSNVMVK KQVFELLAAL
160 170 180 190 200
CIYSPEGHAL SLDALEHYKA VKNQQYRFSV IMNELSTSDN VPYMVTLLSA
210 220 230 240 250
INAIIFGTEE LRKRVQLRNE FIGLQLLDLL TKLRDLEDED LLIQAIVFEE
260 270 280 290 300
AKSEDEEELL KIYGGIDMNN HQEVFSTLFN KVSCSPLSVQ LLSVLQGLLH
310 320 330 340 350
LDQSHPSSPL LWEALDILVN RAVLLADDCQ NNNVEEVMDR LVTSKKHPSK
360 370 380 390 400
EKRKPDKCTN QVNKSIQTDK PKDESCEEKT VKKDPVSSGI PADSLQLSDA
410 420 430 440 450
LLALPACVSP LHTPLSGDIT SPSHFPSPPS PVVSNAIDRI STSSSLPPPL
460 470 480 490 500
PPPLPGTELS LPPPPPPPLP GMGGISLTPP PPPPLPGMGG MLPPPPPPLP
510 520 530 540 550
GMGGMLPPPP PPLPGMGGML PPPPPPLPGM GGMLPPPPPP LPGMGGMPPP
560 570 580 590 600
PPPLPGMGGM PPPPPPMFGM GTFTDEVVVA RVDYSLGYLP KAYFKVNKPT
610 620 630 640 650
LKMKKLNWQK LPPNVINDTH SMWASASSSN DTPEPNYSSI EQLFCLPQAV
660 670 680 690 700
AKEPAAPVKK PPKEISFLDS KKNLNLNIFL KQFKCPNEEV IQLIEKGDRS
710 720 730 740 750
RFDIEILKQF LKLLPEKHEV ENLKSYQEDK AKLSNADQFY LLLLGIPCYQ
760 770 780 790 800
LRIECMLICE EVNLMTDVLR PKAKVVSSAC DDIISSHRLP LFCQLILKVG
810 820 830 840 850
NFLNYGSHTG NANGFKIGTL LKLTETKANQ NRITLLHHIL EEIEQNHTDL
860 870 880 890 900
LQLPSDLENV STAAGINIEN MYSETSGNLK KLRDLQNKIS TAATDVKDQY
910 920 930 940 950
EKSIQECMDA LKEVEEQLTD ITQKKVKLAD YLCEDSAKLS LEETFSTMKA
960 970 980 990 1000
FRDLFLKAKK DNKDRKEQAV KAEKRKKQLA DEEAKRQKGE NGKIIRKGAA
1010 1020 1030 1040 1050
KLEEGCIIDA LLADIKKGFQ LRKTAKTKTE ADSCPKPVSS ETTGTDGTDV
1060 1070 1080 1090 1100
KHVDHVGILP QIKLDSSLNL DGTEQHKSKS KDNCGENFDN KPVVIAPINL
1110 1120 1130 1140 1150
DTSACLMNIS EQNAKLPVSA LQEGANLKQN PDTFVKEQSA IVTTESSTHN
1160 1170 1180 1190 1200
NIDGSSVDKC TLGQSQWPSE ISDEVDSKYH EMPMQVEHKE RAVEGKCSLP
1210 1220 1230 1240 1250
KPSVLGTESS SNQNNALNEG SQQHHNNTAN ESLQQAQNSA LSEASQQSCC
1260 1270 1280 1290 1300
HTGIKGSPQF QSSALNADSQ PSHTSVVGSA QAQRNELDDV ALQTRDTTVT
1310 1320 1330 1340 1350
EGSQVEEDKC NDEGYPEHKT MGEHPLNSSS HSTTLQQSSE DGQKVKRGSS
1360 1370 1380
KHKKKRRSSK HGEEDGVDSP THKTRGCVVQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A8J0SV66 | A0A8J0SV66_XENTR | inverted formin-2 isoform X3 | inf2 | 1,113 | Annotation score: | ||
A0A8J1ILQ8 | A0A8J1ILQ8_XENTR | inverted formin-2 isoform X4 | inf2 | 1,063 | Annotation score: | ||
A0A8J1ILS0 | A0A8J1ILS0_XENTR | inverted formin-2 isoform X5 | inf2 | 234 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC122958 mRNA Translation: AAI22959.1 |
RefSeqi | NP_001072591.1, NM_001079123.1 XP_012824085.1, XM_012968631.2 XP_012824086.1, XM_012968632.2 XP_012824087.1, XM_012968633.2 XP_017951812.1, XM_018096323.1 |
Genome annotation databases
GeneIDi | 780046 |
KEGGi | xtr:780046 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC122958 mRNA Translation: AAI22959.1 |
RefSeqi | NP_001072591.1, NM_001079123.1 XP_012824085.1, XM_012968631.2 XP_012824086.1, XM_012968632.2 XP_012824087.1, XM_012968633.2 XP_017951812.1, XM_018096323.1 |
3D structure databases
AlphaFoldDBi | Q0IHV1 |
SMRi | Q0IHV1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000018819 |
Proteomic databases
PaxDbi | Q0IHV1 |
PRIDEi | Q0IHV1 |
Genome annotation databases
GeneIDi | 780046 |
KEGGi | xtr:780046 |
Organism-specific databases
CTDi | 64423 |
Xenbasei | XB-GENE-5862185, inf2 |
Phylogenomic databases
eggNOGi | KOG1922, Eukaryota |
HOGENOMi | CLU_005383_1_0_1 |
InParanoidi | Q0IHV1 |
OMAi | DHYKMVC |
OrthoDBi | 1204639at2759 |
PhylomeDBi | Q0IHV1 |
TreeFami | TF326300 |
Gene expression databases
Bgeei | ENSXETG00000008613, Expressed in female gonad and 11 other tissues |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR014768, GBD/FH3_dom IPR010473, GTPase-bd IPR027649, Inf2 IPR003124, WH2_dom |
PANTHERi | PTHR46345, PTHR46345, 2 hits |
Pfami | View protein in Pfam PF06367, Drf_FH3, 1 hit PF06371, Drf_GBD, 1 hit PF02181, FH2, 1 hit PF02205, WH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM01140, Drf_GBD, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit PS51082, WH2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | INF2_XENTR | |
Accessioni | Q0IHV1Primary (citable) accession number: Q0IHV1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 14, 2006 |
Last sequence update: | October 3, 2006 | |
Last modified: | May 25, 2022 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families