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Protein

Chemotaxis response regulator protein-glutamate methylesterase 2

Gene

cheB2

Organism
Shewanella sp. (strain MR-7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168UniRule annotation1
Active sitei194UniRule annotation1
Active sitei290UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 2UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB2UniRule annotation
Ordered Locus Names:Shewmr7_1886
OrganismiShewanella sp. (strain MR-7)
Taxonomic identifieri60481 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001960 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002643241 – 351Chemotaxis response regulator protein-glutamate methylesterase 2Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ0HVI0
SMRiQ0HVI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini156 – 348CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000151423
KOiK03412
OMAiMLEMHRA

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q0HVI0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIKVLVVDD SALIRNLLGK MIEADSELSL VGMAADAYMA KDMVNQHRPD
60 70 80 90 100
VITLDIEMPK VDGLTFLDRL MKARPTAVVM ISSLTEEGAD ATFNALALGA
110 120 130 140 150
VDFIPKPKLD SPQDFNEYQD LILEKIKSAA HAKLKTQRAA PAVVVQPSHK
160 170 180 190 200
PALSNRVINT QLVAIGASTG GTEAILSLLQ QFPAVMPPIV ITQHMPPGFT
210 220 230 240 250
RTFAERLNKL TRLNVKQAED GERLLPCYVY IAPGDQHLEV IKVGGSFKTR
260 270 280 290 300
LTQGDKVSGH RPSVDVLFNS VAECAGANTT AAILTGMGKD GADGMALIDE
310 320 330 340 350
QGGKTFAQGE QSCVVFGMPR EAIKRGVIHH VVELPQLADK MLNYLASLKR

D
Length:351
Mass (Da):37,905
Last modified:October 3, 2006 - v1
Checksum:iB2CC7D606E73A571
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000444 Genomic DNA Translation: ABI42875.1
RefSeqiWP_011626102.1, NC_008322.1

Genome annotation databases

EnsemblBacteriaiABI42875; ABI42875; Shewmr7_1886
KEGGishm:Shewmr7_1886

Similar proteinsi

Entry informationi

Entry nameiCHEB2_SHESR
AccessioniPrimary (citable) accession number: Q0HVI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 3, 2006
Last modified: November 22, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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