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Protein

Argininosuccinate lyase

Gene

argH

Organism
Shewanella sp. (strain MR-4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciSSP60480:G1G76-3881-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Shewmr4_3705
OrganismiShewanella sp. (strain MR-4)
Taxonomic identifieri60480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000005411 – 455Argininosuccinate lyaseAdd BLAST455

Structurei

3D structure databases

ProteinModelPortaliQ0HDU9
SMRiQ0HDU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q0HDU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWGGRFQG ETSALFKLFN DSLPVDYRLF EQDVVGSIAW ADAIASVGII
60 70 80 90 100
TATECSDLKK ALNELLVEVK GDPAIILASG AEDIHSFVES ALIAKVGDLG
110 120 130 140 150
KKLHTGRSRN DQVATDLKLW CQSEGAALVA RLQTLRSELI ALAEREFDAV
160 170 180 190 200
MPGYTHLQRA QPVTFGHWCL AYVEMIERDL SRLTDALKRA NTCPLGSGAL
210 220 230 240 250
AGTAYQMDRH ALAAALNFAS PTLNSLDSVS DRDHVVELCS TASISMMHLS
260 270 280 290 300
RMAEDLIFFN SGEAGFISLS DEVTSGSSLM PQKKNPDALE LIRGKTGRVY
310 320 330 340 350
GSLVGILTTM KALPLAYNKD MQEDKEGLFD VVDSWAICLD MAALVLSGLV
360 370 380 390 400
VNRPNALLAA QQGYANATEL ADYLVSKGMP FREAHHVVGV AVVAAIAKKI
410 420 430 440 450
PLEGFTLAEF KTFADIIEDD VYPNLTIEAC LAKRDVLGGT ALAQVKQAIA

AKNAG
Length:455
Mass (Da):48,921
Last modified:October 3, 2006 - v1
Checksum:iFDAFC78CACCA8AD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000446 Genomic DNA Translation: ABI40768.1
RefSeqiWP_011624427.1, NC_008321.1

Genome annotation databases

EnsemblBacteriaiABI40768; ABI40768; Shewmr4_3705
KEGGishe:Shewmr4_3705

Similar proteinsi

Entry informationi

Entry nameiARLY_SHESM
AccessioniPrimary (citable) accession number: Q0HDU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: February 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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