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Entry version 107 (13 Nov 2019)
Sequence version 1 (03 Oct 2006)
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Protein

Thymidine kinase

Gene

tdk

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei89Proton acceptorUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi145ZincUniRule annotationCombined sources1
Metal bindingi148ZincUniRule annotationCombined sources1
Metal bindingi183ZincUniRule annotationCombined sources1
Metal bindingi186ZincUniRule annotation1
Metal bindingi186Zinc; via pros nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotationCombined sources, Nucleotide-binding, ZincUniRule annotationCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tdkUniRule annotationImported
Synonyms:tdk_1Imported
ORF Names:BTN44_12945Imported, C7P97_10700Imported, CSC83_06075Imported, CSC87_01000Imported, CV021_10205Imported, E4U00_12030Imported, EP54_10835Imported, EQ90_06730Imported, ER627_10190Imported, ERS072840_01851Imported, FA040_09565Imported, FVP29_10565Imported, NCTC10654_02282Imported, NCTC13131_01454Imported, NCTC6133_02880Imported, NCTC7878_02877Imported, NCTC7988_02196Imported, RK64_11250Imported, SAMEA1708674_02566Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1280 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000298587 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000271693 Componenti: Chromosome 1
  • UP000251686 Componenti: Unassembled WGS sequence
  • UP000236484 Componenti: Chromosome
  • UP000069800 Componenti: Unassembled WGS sequence
  • UP000249689 Componenti: Unassembled WGS sequence
  • UP000315717 Componenti: Unassembled WGS sequence
  • UP000298183 Componenti: Unassembled WGS sequence
  • UP000249913 Componenti: Unassembled WGS sequence
  • UP000238775 Componenti: Unassembled WGS sequence
  • UP000249308 Componenti: Unassembled WGS sequence
  • UP000255075 Componenti: Unassembled WGS sequence
  • UP000035281 Componenti: Chromosome
  • UP000239144 Componenti: Unassembled WGS sequence
  • UP000255091 Componenti: Unassembled WGS sequence
  • UP000321897 Componenti: Unassembled WGS sequence
  • UP000239106 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5323

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107104 Bacteria
COG1435 LUCA

KEGG Orthology (KO)

More...
KOi
K00857

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00124 Thymidine_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11441 PTHR11441, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00265 TK, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF035805 TK_cell, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q0H0G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY
60 70 80 90 100
HKEKVVSHNG NAIEAINISK ASEIMTHDLT NVDVIGIDEV QFFDDEIVSI
110 120 130 140 150
VEKLSADGHR VIVAGLDMDF RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS
160 170 180 190
SSSRTQRLIN GKPAKIDDPI ILVGANESYE PRCRAHHIVA PSDNNKEEL
Length:199
Mass (Da):22,214
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1EC76B7C5645909
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ384605 Genomic DNA Translation: ABD37699.1
CP018629 Genomic DNA Translation: AUS76078.1
CP026962 Genomic DNA Translation: AVG64709.1
FGEC01000013 Genomic DNA Translation: CXN91953.1
LALJ01000010 Genomic DNA Translation: KMR36787.1
LALQ01000048 Genomic DNA Translation: KMR56435.1
PGWZ01000404 Genomic DNA Translation: PPJ73504.1
PDUY01000082 Genomic DNA Translation: PPJ94827.1
PDVL01000004 Genomic DNA Translation: PPK16501.1
PZSP01000037 Genomic DNA Translation: PZJ39253.1
SDOE01000008 Genomic DNA Translation: RXS32426.1
FMPP01000014 Genomic DNA Translation: SCT27430.1
UAUX01000010 Genomic DNA Translation: SPZ99732.1
UAUZ01000002 Genomic DNA Translation: SQA08426.1
UHAP01000001 Genomic DNA Translation: SUK57854.1
UHBX01000004 Genomic DNA Translation: SUL30393.1
SPPY01000005 Genomic DNA Translation: TFU34901.1
SWED01000011 Genomic DNA Translation: TKC11139.1
VRSB01000947 Genomic DNA Translation: TXO09597.1
LR134271 Genomic DNA Translation: VED81880.1

NCBI Reference Sequences

More...
RefSeqi
WP_000273356.1, NZ_VSZH01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CFG07304; CFG07304; ERS093009_02316
CXE77994; CXE77994; ERS074020_01889
CXM25007; CXM25007; ERS072738_01928
CXN91953; CXN91953; ERS072840_01851
CXT33606; CXT33606; ERS073147_01795
CYD40889; CYD40889; ERS073767_02050
CZQ30320; CZQ30320; ERS1058648_01983
OAP74096; OAP74096; A4U86_07125
SCR61047; SCR61047; SAMEA2298760_02239

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sams:NI36_10400
saur:SABB_03255

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1280.10758.peg.1900

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ384605 Genomic DNA Translation: ABD37699.1
CP018629 Genomic DNA Translation: AUS76078.1
CP026962 Genomic DNA Translation: AVG64709.1
FGEC01000013 Genomic DNA Translation: CXN91953.1
LALJ01000010 Genomic DNA Translation: KMR36787.1
LALQ01000048 Genomic DNA Translation: KMR56435.1
PGWZ01000404 Genomic DNA Translation: PPJ73504.1
PDUY01000082 Genomic DNA Translation: PPJ94827.1
PDVL01000004 Genomic DNA Translation: PPK16501.1
PZSP01000037 Genomic DNA Translation: PZJ39253.1
SDOE01000008 Genomic DNA Translation: RXS32426.1
FMPP01000014 Genomic DNA Translation: SCT27430.1
UAUX01000010 Genomic DNA Translation: SPZ99732.1
UAUZ01000002 Genomic DNA Translation: SQA08426.1
UHAP01000001 Genomic DNA Translation: SUK57854.1
UHBX01000004 Genomic DNA Translation: SUL30393.1
SPPY01000005 Genomic DNA Translation: TFU34901.1
SWED01000011 Genomic DNA Translation: TKC11139.1
VRSB01000947 Genomic DNA Translation: TXO09597.1
LR134271 Genomic DNA Translation: VED81880.1
RefSeqiWP_000273356.1, NZ_VSZH01000002.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E2IX-ray2.01A1-199[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Chemistry databases

ChEMBLiCHEMBL5323

Genome annotation databases

EnsemblBacteriaiCFG07304; CFG07304; ERS093009_02316
CXE77994; CXE77994; ERS074020_01889
CXM25007; CXM25007; ERS072738_01928
CXN91953; CXN91953; ERS072840_01851
CXT33606; CXT33606; ERS073147_01795
CYD40889; CYD40889; ERS073767_02050
CZQ30320; CZQ30320; ERS1058648_01983
OAP74096; OAP74096; A4U86_07125
SCR61047; SCR61047; SAMEA2298760_02239
KEGGisams:NI36_10400
saur:SABB_03255
PATRICifig|1280.10758.peg.1900

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
KOiK00857

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ0H0G9_STAAU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0H0G9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 13, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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