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UniProtKB - Q0GNC1 (INF2_MOUSE)

Entry version 102 (25 May 2022)
Sequence version 1 (03 Oct 2006)
Previous versions | rss
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Protein

Inverted formin-2

Gene

Inf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Severs actin filaments and accelerates their polymerization and depolymerization.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Phosphate inhibits both the depolymerization and severing activities.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inverted formin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Inf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1917685, Inf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1009L → A: Strongly inhibits depolymerization; when associated with A-1010 and A-1019. 1 Publication1
Mutagenesisi1010L → A: Strongly inhibits depolymerization; when associated with A-1009 and A-1019. 1 Publication1
Mutagenesisi1019L → A: Strongly inhibits depolymerization; when associated with A-1009 and A-1010. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002598902 – 1273Inverted formin-2Add BLAST1272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei351PhosphoserineBy similarity1
Modified residuei1172PhosphoserineCombined sources1
Modified residuei1174PhosphoserineCombined sources1
Modified residuei1203PhosphothreonineCombined sources1
Modified residuei1216PhosphoserineBy similarity1
Modified residuei1218PhosphoserineBy similarity1
Modified residuei1223PhosphothreonineCombined sources1
Modified residuei1230PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q0GNC1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q0GNC1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q0GNC1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q0GNC1

PeptideAtlas

More...PeptideAtlasi		Q0GNC1

PRoteomics IDEntifications database

More...PRIDEi		Q0GNC1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		269405 [Q0GNC1-1]
269406 [Q0GNC1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q0GNC1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q0GNC1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with profilin and actin at the FH1 and FH2 domains respectively.

Interacts with DAAM2 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		214049, 4 interactors

Database of interacting proteins

More...DIPi		DIP-61548N

Protein interaction database and analysis system

More...IntActi		Q0GNC1, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000098591

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q0GNC1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q0GNC1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q0GNC1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 330GBD/FH3PROSITE-ProRule annotationAdd BLAST329
Domaini421 – 564FH1Add BLAST144
Domaini589 – 979FH2PROSITE-ProRule annotationAdd BLAST391
Domaini1007 – 1022WH2PROSITE-ProRule annotationAdd BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni346 – 387DisorderedSequence analysisAdd BLAST42
Regioni427 – 559DisorderedSequence analysisAdd BLAST133
Regioni960 – 999DisorderedSequence analysisAdd BLAST40
Regioni1021 – 1273DisorderedSequence analysisAdd BLAST253

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili907 – 984Sequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 22Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi356 – 387Polar residuesSequence analysisAdd BLAST32
Compositional biasi1044 – 1063Polar residuesSequence analysisAdd BLAST20
Compositional biasi1136 – 1151Polar residuesSequence analysisAdd BLAST16
Compositional biasi1209 – 1237Polar residuesSequence analysisAdd BLAST29
Compositional biasi1249 – 1267Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WH2 domain acts as the DAD (diaphanous autoregulatory) domain and binds to actin monomers.1 Publication
Regulated by autoinhibition due to intramolecular GBD-DAD binding.1 Publication
The severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the formin homology family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1922, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q0GNC1

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q0GNC1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd
IPR027649, Inf2
IPR003124, WH2_dom

The PANTHER Classification System

More...PANTHERi		PTHR46345, PTHR46345, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit
PF02205, WH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit
PS51082, WH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q0GNC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVKEGAQRK WAALKEKLGP QDSDPTEANL ESAEPELCIR LLQMPSVVNY 
        60         70         80         90        100
SGLRKRLESS DGGWMVQFLE QSGLDLLLEA LARLSGRGVA RISDALLQLT 
       110        120        130        140        150
CISCVRAVMN SQQGIEYILS NQGYVRQLSQ ALDTSNVMVK KQVFELLAAL 
       160        170        180        190        200
CIYSPEGHAL TLDALDHYKM VCSQQYRFSV IMSELSDSDN VPYVVTLLSV 
       210        220        230        240        250
INAIILGPED LRSRAQLRSE FIGLQLLDIL TRLRDLEDAD LLIQLEAFEE 
       260        270        280        290        300
AKAEDEEELQ RISDGINMNS HQEVFASLFH KVSCSPASAQ LLSVLQGLMH 
       310        320        330        340        350
LEPAGRSGQL LWEALENLVN RAVLLASDAQ ACTLEEVVER LLSIKGRPRP 
       360        370        380        390        400
SPLDKAHKSV QTNSVQNQGS SSQNTTTPTT KVEGQQPVVA SPCQHVGSIQ 
       410        420        430        440        450
SSSVDIAPQP VALEQCITAL PLPTPPLSSS TPVLPPTPPP LPGPGATSPL 
       460        470        480        490        500
PPPPPPLPPP LPGSGTTSPP PPPPPPPPLP PPLPGSGTIS PPPPPPPPPL 
       510        520        530        540        550
PGTGAVSPPP PPPLPSLPDS HKTQPPPPPP PPLPGMCPVP PPPPLPRAGQ 
       560        570        580        590        600
IPPPPPLPGF SVPSMMGGVE EIIVAQVDHS LGSAWVPSHR RVNPPTLRMK 
       610        620        630        640        650
KLNWQKLPSN VARERNSMWA TLGSPCTAAV EPDFSSIEQL FSFPTAKPKE 
       660        670        680        690        700
PSAAPARKEP KEVTFLDSKK SLNLNIFLKQ FKCSNEEVTS MIQAGDTSKF 
       710        720        730        740        750
DVEVLKQLLK LLPEKHEIEN LRAFTEERAK LSNADQFYVL LLDIPCYPLR 
       760        770        780        790        800
VECMMLCEGT AIVLDMVRPK AQLVLTACES LLTSQRLPVF CQLILKIGNF 
       810        820        830        840        850
LNYGSHTGDA DGFKISTLLK LTETKSQQSR VTLLHHVLEE VEKSHPDLLQ 
       860        870        880        890        900
LSRDLEPPSQ AAGINVEIIH SEASANLKKL LEAERKVSAS IPEVQKQYAE 
       910        920        930        940        950
RLQASIEASQ ELDKVFDAIE QKKLELADYL CEDPQQLSLE DTFSTMKTFR 
       960        970        980        990       1000
DLFTRALKEN KDRKEQMAKA ERRKQQLAEE EARRPRDEDG KPIRKGPGKQ 
      1010       1020       1030       1040       1050
EEVCVIDALL ADIRKGFQLR KTARGRGDTE ASGRVAPTDP PKATEPATAS 
      1060       1070       1080       1090       1100
NPTQGTNHPA SEPLDTTAAD EPQGWDLVDA VTPSPQPSKE EDGPPALERR 
      1110       1120       1130       1140       1150
SSWYVDAIDF LDPEDTPDAQ PSEGVWPVTL GDGQALNPLE FSSNKPPGVK 
      1160       1170       1180       1190       1200
SSHQDATDPE ALWGVHQTEA DSTSEGPEDE AQRGQSTHLP RTGPGEDEDG 
      1210       1220       1230       1240       1250
EDTAPESALD TSLDRSFSED AVTDSSGSGT LPRVQGRVSK GTSKRRKKRP 
      1260       1270 
SRNQEEFVPD SDDIKAKRLC VIQ
Length:1,273
Mass (Da):138,560
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC4438AD8A7041476
GO
Isoform 2 (identifier: Q0GNC1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1256-1273: EFVPDSDDIKAKRLCVIQ → GLRSRPKAK

Show »
Length:1,264
Mass (Da):137,496
Checksum:iCC8EEF55F65801CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QLA5E9QLA5_MOUSE
Inverted formin-2
Inf2
1,271Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VM80A0A1Y7VM80_MOUSE
Inverted formin-2
Inf2
720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VLQ6A0A1Y7VLQ6_MOUSE
Inverted formin-2
Inf2
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH60610 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH99931 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1038T → A in AAH60610 (PubMed:15489334).Curated1
Sequence conflicti1038T → A in AAI15423 (PubMed:15489334).Curated1
Sequence conflicti1167Q → R in AAH60610 (PubMed:15489334).Curated1
Sequence conflicti1167Q → R in AAI15423 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0215601256 – 1273EFVPD…LCVIQ → GLRSRPKAK in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ834374 mRNA Translation: ABI20145.1
BC060610 mRNA Translation: AAH60610.1 Different initiation.
BC099931 mRNA Translation: AAH99931.1 Different initiation.
BC115422 mRNA Translation: AAI15423.2
BC115423 mRNA Translation: AAI15424.2

NCBI Reference Sequences

More...RefSeqi		NP_940803.2, NM_198411.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		70435

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:70435

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ834374 mRNA Translation: ABI20145.1
BC060610 mRNA Translation: AAH60610.1 Different initiation.
BC099931 mRNA Translation: AAH99931.1 Different initiation.
BC115422 mRNA Translation: AAI15423.2
BC115423 mRNA Translation: AAI15424.2
RefSeqiNP_940803.2, NM_198411.2

3D structure databases

AlphaFoldDBiQ0GNC1
SMRiQ0GNC1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi214049, 4 interactors
DIPiDIP-61548N
IntActiQ0GNC1, 3 interactors
STRINGi10090.ENSMUSP00000098591

PTM databases

iPTMnetiQ0GNC1
PhosphoSitePlusiQ0GNC1

Proteomic databases

EPDiQ0GNC1
jPOSTiQ0GNC1
MaxQBiQ0GNC1
PaxDbiQ0GNC1
PeptideAtlasiQ0GNC1
PRIDEiQ0GNC1
ProteomicsDBi269405 [Q0GNC1-1]
269406 [Q0GNC1-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		70435

Genome annotation databases

GeneIDi70435
KEGGimmu:70435

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64423
MGIiMGI:1917685, Inf2

Phylogenomic databases

eggNOGiKOG1922, Eukaryota
InParanoidiQ0GNC1
PhylomeDBiQ0GNC1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		70435, 3 hits in 74 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Inf2, mouse

Protein Ontology

More...PROi		PR:Q0GNC1
RNActiQ0GNC1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd
IPR027649, Inf2
IPR003124, WH2_dom
PANTHERiPTHR46345, PTHR46345, 2 hits
PfamiView protein in Pfam
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit
PF02205, WH2, 1 hit
SMARTiView protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit
PS51082, WH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINF2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0GNC1
Secondary accession number(s): Q14C56, Q499F7, Q6P9T3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: October 3, 2006
Last modified: May 25, 2022
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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