UniProtKB - Q0GNC1 (INF2_MOUSE)
Inverted formin-2
Inf2
Functioni
Severs actin filaments and accelerates their polymerization and depolymerization.
1 PublicationActivity regulationi
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- small GTPase binding Source: InterPro
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- regulation of cellular component size Source: MGI
- regulation of mitochondrial fission Source: MGI
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Inverted formin-2 |
Gene namesi | Name:Inf2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1917685, Inf2 |
Subcellular locationi
Other locations
- perinuclear region By similarity
Other locations
- perinuclear region of cytoplasm Source: MGI
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1009 | L → A: Strongly inhibits depolymerization; when associated with A-1010 and A-1019. 1 Publication | 1 | |
Mutagenesisi | 1010 | L → A: Strongly inhibits depolymerization; when associated with A-1009 and A-1019. 1 Publication | 1 | |
Mutagenesisi | 1019 | L → A: Strongly inhibits depolymerization; when associated with A-1009 and A-1010. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000259890 | 2 – 1273 | Inverted formin-2Add BLAST | 1272 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 351 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1172 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1174 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1203 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1216 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1218 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1223 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1230 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q0GNC1 |
jPOSTi | Q0GNC1 |
MaxQBi | Q0GNC1 |
PaxDbi | Q0GNC1 |
PeptideAtlasi | Q0GNC1 |
PRIDEi | Q0GNC1 |
ProteomicsDBi | 269405 [Q0GNC1-1] 269406 [Q0GNC1-3] |
PTM databases
iPTMneti | Q0GNC1 |
PhosphoSitePlusi | Q0GNC1 |
Interactioni
Subunit structurei
Interacts with profilin and actin at the FH1 and FH2 domains respectively.
Interacts with DAAM2 (By similarity).
By similarity1 PublicationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
- small GTPase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 214049, 4 interactors |
DIPi | DIP-61548N |
IntActi | Q0GNC1, 3 interactors |
STRINGi | 10090.ENSMUSP00000098591 |
Miscellaneous databases
RNActi | Q0GNC1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 330 | GBD/FH3PROSITE-ProRule annotationAdd BLAST | 329 | |
Domaini | 421 – 564 | FH1Add BLAST | 144 | |
Domaini | 589 – 979 | FH2PROSITE-ProRule annotationAdd BLAST | 391 | |
Domaini | 1007 – 1022 | WH2PROSITE-ProRule annotationAdd BLAST | 16 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 346 – 387 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 427 – 559 | DisorderedSequence analysisAdd BLAST | 133 | |
Regioni | 960 – 999 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 1021 – 1273 | DisorderedSequence analysisAdd BLAST | 253 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 907 – 984 | Sequence analysisAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 22 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 356 – 387 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1044 – 1063 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1136 – 1151 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1209 – 1237 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1249 – 1267 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1922, Eukaryota |
InParanoidi | Q0GNC1 |
PhylomeDBi | Q0GNC1 |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR014768, GBD/FH3_dom IPR010473, GTPase-bd IPR027649, Inf2 IPR003124, WH2_dom |
PANTHERi | PTHR46345, PTHR46345, 2 hits |
Pfami | View protein in Pfam PF06367, Drf_FH3, 1 hit PF06371, Drf_GBD, 1 hit PF02181, FH2, 1 hit PF02205, WH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM01140, Drf_GBD, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit PS51082, WH2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVKEGAQRK WAALKEKLGP QDSDPTEANL ESAEPELCIR LLQMPSVVNY
60 70 80 90 100
SGLRKRLESS DGGWMVQFLE QSGLDLLLEA LARLSGRGVA RISDALLQLT
110 120 130 140 150
CISCVRAVMN SQQGIEYILS NQGYVRQLSQ ALDTSNVMVK KQVFELLAAL
160 170 180 190 200
CIYSPEGHAL TLDALDHYKM VCSQQYRFSV IMSELSDSDN VPYVVTLLSV
210 220 230 240 250
INAIILGPED LRSRAQLRSE FIGLQLLDIL TRLRDLEDAD LLIQLEAFEE
260 270 280 290 300
AKAEDEEELQ RISDGINMNS HQEVFASLFH KVSCSPASAQ LLSVLQGLMH
310 320 330 340 350
LEPAGRSGQL LWEALENLVN RAVLLASDAQ ACTLEEVVER LLSIKGRPRP
360 370 380 390 400
SPLDKAHKSV QTNSVQNQGS SSQNTTTPTT KVEGQQPVVA SPCQHVGSIQ
410 420 430 440 450
SSSVDIAPQP VALEQCITAL PLPTPPLSSS TPVLPPTPPP LPGPGATSPL
460 470 480 490 500
PPPPPPLPPP LPGSGTTSPP PPPPPPPPLP PPLPGSGTIS PPPPPPPPPL
510 520 530 540 550
PGTGAVSPPP PPPLPSLPDS HKTQPPPPPP PPLPGMCPVP PPPPLPRAGQ
560 570 580 590 600
IPPPPPLPGF SVPSMMGGVE EIIVAQVDHS LGSAWVPSHR RVNPPTLRMK
610 620 630 640 650
KLNWQKLPSN VARERNSMWA TLGSPCTAAV EPDFSSIEQL FSFPTAKPKE
660 670 680 690 700
PSAAPARKEP KEVTFLDSKK SLNLNIFLKQ FKCSNEEVTS MIQAGDTSKF
710 720 730 740 750
DVEVLKQLLK LLPEKHEIEN LRAFTEERAK LSNADQFYVL LLDIPCYPLR
760 770 780 790 800
VECMMLCEGT AIVLDMVRPK AQLVLTACES LLTSQRLPVF CQLILKIGNF
810 820 830 840 850
LNYGSHTGDA DGFKISTLLK LTETKSQQSR VTLLHHVLEE VEKSHPDLLQ
860 870 880 890 900
LSRDLEPPSQ AAGINVEIIH SEASANLKKL LEAERKVSAS IPEVQKQYAE
910 920 930 940 950
RLQASIEASQ ELDKVFDAIE QKKLELADYL CEDPQQLSLE DTFSTMKTFR
960 970 980 990 1000
DLFTRALKEN KDRKEQMAKA ERRKQQLAEE EARRPRDEDG KPIRKGPGKQ
1010 1020 1030 1040 1050
EEVCVIDALL ADIRKGFQLR KTARGRGDTE ASGRVAPTDP PKATEPATAS
1060 1070 1080 1090 1100
NPTQGTNHPA SEPLDTTAAD EPQGWDLVDA VTPSPQPSKE EDGPPALERR
1110 1120 1130 1140 1150
SSWYVDAIDF LDPEDTPDAQ PSEGVWPVTL GDGQALNPLE FSSNKPPGVK
1160 1170 1180 1190 1200
SSHQDATDPE ALWGVHQTEA DSTSEGPEDE AQRGQSTHLP RTGPGEDEDG
1210 1220 1230 1240 1250
EDTAPESALD TSLDRSFSED AVTDSSGSGT LPRVQGRVSK GTSKRRKKRP
1260 1270
SRNQEEFVPD SDDIKAKRLC VIQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9QLA5 | E9QLA5_MOUSE | Inverted formin-2 | Inf2 | 1,271 | Annotation score: | ||
A0A1Y7VM80 | A0A1Y7VM80_MOUSE | Inverted formin-2 | Inf2 | 720 | Annotation score: | ||
A0A1Y7VLQ6 | A0A1Y7VLQ6_MOUSE | Inverted formin-2 | Inf2 | 24 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1038 | T → A in AAH60610 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1038 | T → A in AAI15423 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1167 | Q → R in AAH60610 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1167 | Q → R in AAI15423 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021560 | 1256 – 1273 | EFVPD…LCVIQ → GLRSRPKAK in isoform 2. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ834374 mRNA Translation: ABI20145.1 BC060610 mRNA Translation: AAH60610.1 Different initiation. BC099931 mRNA Translation: AAH99931.1 Different initiation. BC115422 mRNA Translation: AAI15423.2 BC115423 mRNA Translation: AAI15424.2 |
RefSeqi | NP_940803.2, NM_198411.2 |
Genome annotation databases
GeneIDi | 70435 |
KEGGi | mmu:70435 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ834374 mRNA Translation: ABI20145.1 BC060610 mRNA Translation: AAH60610.1 Different initiation. BC099931 mRNA Translation: AAH99931.1 Different initiation. BC115422 mRNA Translation: AAI15423.2 BC115423 mRNA Translation: AAI15424.2 |
RefSeqi | NP_940803.2, NM_198411.2 |
3D structure databases
AlphaFoldDBi | Q0GNC1 |
SMRi | Q0GNC1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 214049, 4 interactors |
DIPi | DIP-61548N |
IntActi | Q0GNC1, 3 interactors |
STRINGi | 10090.ENSMUSP00000098591 |
PTM databases
iPTMneti | Q0GNC1 |
PhosphoSitePlusi | Q0GNC1 |
Proteomic databases
EPDi | Q0GNC1 |
jPOSTi | Q0GNC1 |
MaxQBi | Q0GNC1 |
PaxDbi | Q0GNC1 |
PeptideAtlasi | Q0GNC1 |
PRIDEi | Q0GNC1 |
ProteomicsDBi | 269405 [Q0GNC1-1] 269406 [Q0GNC1-3] |
Protocols and materials databases
DNASUi | 70435 |
Genome annotation databases
GeneIDi | 70435 |
KEGGi | mmu:70435 |
Organism-specific databases
CTDi | 64423 |
MGIi | MGI:1917685, Inf2 |
Phylogenomic databases
eggNOGi | KOG1922, Eukaryota |
InParanoidi | Q0GNC1 |
PhylomeDBi | Q0GNC1 |
Miscellaneous databases
BioGRID-ORCSi | 70435, 3 hits in 74 CRISPR screens |
ChiTaRSi | Inf2, mouse |
PROi | PR:Q0GNC1 |
RNActi | Q0GNC1, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR014768, GBD/FH3_dom IPR010473, GTPase-bd IPR027649, Inf2 IPR003124, WH2_dom |
PANTHERi | PTHR46345, PTHR46345, 2 hits |
Pfami | View protein in Pfam PF06367, Drf_FH3, 1 hit PF06371, Drf_GBD, 1 hit PF02181, FH2, 1 hit PF02205, WH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM01140, Drf_GBD, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit PS51082, WH2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | INF2_MOUSE | |
Accessioni | Q0GNC1Primary (citable) accession number: Q0GNC1 Secondary accession number(s): Q14C56, Q499F7, Q6P9T3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 14, 2006 |
Last sequence update: | October 3, 2006 | |
Last modified: | May 25, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families