UniProtKB - Q0GK43 (Q0GK43_HUMAN)
Protein
Interleukin-2
Gene
IL2
Organism
Homo sapiens (Human)
Status
Functioni
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.UniRule annotation
GO - Molecular functioni
- carbohydrate binding Source: Ensembl
- cytokine activity Source: UniProtKB-KW
- glycosphingolipid binding Source: Ensembl
- growth factor activity Source: UniProtKB-KW
- interleukin-2 receptor binding Source: Ensembl
- kappa-type opioid receptor binding Source: Ensembl
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- negative regulation of heart contraction Source: Ensembl
- negative regulation of inflammatory response Source: Ensembl
- negative regulation of lymphocyte proliferation Source: Ensembl
- negative regulation of protein phosphorylation Source: Ensembl
- negative regulation of T-helper 17 cell differentiation Source: Ensembl
- positive regulation of activated T cell proliferation Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of dendritic spine development Source: Ensembl
- positive regulation of immunoglobulin secretion Source: Ensembl
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of isotype switching to IgG isotypes Source: Ensembl
- positive regulation of regulatory T cell differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- regulation of T cell homeostatic proliferation Source: Ensembl
- response to ethanol Source: Ensembl
Keywordsi
Molecular function | CytokineUniRule annotation, Growth factorUniRule annotation |
Biological process | Adaptive immunityUniRule annotationARBA annotation, Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-2UniRule annotationARBA annotationShort name: IL-2UniRule annotation |
Gene namesi | Name:IL2UniRule annotationImported ORF Names:hCG_38828Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000109471.4 |
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedUniRule annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | UniRule annotationAdd BLAST | 20 | |
ChainiPRO_5014205719 | 21 – 153 | Interleukin-2UniRule annotationAdd BLAST | 133 |
Keywords - PTMi
Disulfide bondUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000109471, Expressed in small intestine Peyer's patch and 74 other tissues |
ExpressionAtlasi | Q0GK43, baseline and differential |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-2 receptor binding Source: Ensembl
- kappa-type opioid receptor binding Source: Ensembl
Chemistry databases
BindingDBi | Q0GK43 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 76 – 96 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, SignalUniRule annotationPhylogenomic databases
HOGENOMi | CLU_124210_0_0_1 |
OMAi | FCQSIFS |
OrthoDBi | 1491449at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000779, IL-2 IPR030477, IL-2_CS |
Pfami | View protein in Pfam PF00715, IL2, 1 hit |
PRINTSi | PR00265, INTERLEUKIN2 |
SMARTi | View protein in SMART SM00189, IL2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00424, INTERLEUKIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0GK43-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
110 120 130 140 150
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS
TLT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ861285 mRNA Translation: ABI20697.1 AB451325 mRNA Translation: BAG70139.1 AB451454 mRNA Translation: BAG70268.1 CH471056 Genomic DNA Translation: EAX05227.1 |
RefSeqi | NP_000577.2, NM_000586.3 |
Genome annotation databases
GeneIDi | 3558 |
KEGGi | hsa:3558 |
UCSCi | uc003ier.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ861285 mRNA Translation: ABI20697.1 AB451325 mRNA Translation: BAG70139.1 AB451454 mRNA Translation: BAG70268.1 CH471056 Genomic DNA Translation: EAX05227.1 |
RefSeqi | NP_000577.2, NM_000586.3 |
3D structure databases
SMRi | Q0GK43 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q0GK43 |
Protocols and materials databases
Antibodypediai | 4147, 1967 antibodies |
DNASUi | 3558 |
Genome annotation databases
GeneIDi | 3558 |
KEGGi | hsa:3558 |
UCSCi | uc003ier.4, human |
Organism-specific databases
CTDi | 3558 |
EuPathDBi | HostDB:ENSG00000109471.4 |
PharmGKBi | PA195 |
Phylogenomic databases
HOGENOMi | CLU_124210_0_0_1 |
OMAi | FCQSIFS |
OrthoDBi | 1491449at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3558, 2 hits in 842 CRISPR screens |
ChiTaRSi | IL2, human |
GenomeRNAii | 3558 |
Gene expression databases
Bgeei | ENSG00000109471, Expressed in small intestine Peyer's patch and 74 other tissues |
ExpressionAtlasi | Q0GK43, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000779, IL-2 IPR030477, IL-2_CS |
Pfami | View protein in Pfam PF00715, IL2, 1 hit |
PRINTSi | PR00265, INTERLEUKIN2 |
SMARTi | View protein in SMART SM00189, IL2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00424, INTERLEUKIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q0GK43_HUMAN | |
Accessioni | Q0GK43Primary (citable) accession number: Q0GK43 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2006 |
Last sequence update: | October 3, 2006 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |