IL2

Functionⁱ

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.

UniRule annotation

GO - Molecular functionⁱ

carbohydrate binding Source: Ensembl
cytokine activity Source: UniProtKB-KW
glycosphingolipid binding Source: Ensembl
growth factor activity Source: UniProtKB-KW
interleukin-2 receptor binding Source: Ensembl
kappa-type opioid receptor binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
gene expression Source: Ensembl
negative regulation of heart contraction Source: Ensembl
negative regulation of inflammatory response Source: Ensembl
negative regulation of lymphocyte proliferation Source: Ensembl
negative regulation of protein phosphorylation Source: Ensembl
negative regulation of T-helper 17 cell differentiation Source: Ensembl
positive regulation of activated T cell proliferation Source: Ensembl
positive regulation of cytosolic calcium ion concentration Source: Ensembl
positive regulation of dendritic spine development Source: Ensembl
positive regulation of interferon-gamma production Source: Ensembl
positive regulation of isotype switching to IgG isotypes Source: Ensembl
positive regulation of regulatory T cell differentiation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
regulation of T cell homeostatic proliferation Source: Ensembl
response to ethanol Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	CytokineUniRule annotation, Growth factorUniRule annotation
Biological process	Adaptive immunityUniRule annotationARBA annotation, Immunity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-2UniRule annotationARBA annotation Short name: IL-2UniRule annotation
Gene namesⁱ	Name:IL2UniRule annotationImported ORF Names:hCG_38828Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

VEuPathDBⁱ	HostDB:ENSG00000109471.4

VEuPathDBⁱ

HostDB:ENSG00000109471.4

Keywords - Cellular componentⁱ

SecretedUniRule annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA195

PharmGKBⁱ

PA195

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	UniRule annotationAdd BLAST		20
ChainⁱPRO_5014205719	21 – 153	Interleukin-2UniRule annotationAdd BLAST		133

Keywords - PTMⁱ

Disulfide bondUniRule annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000109471, Expressed in small intestine Peyer's patch and 76 other tissues
ExpressionAtlasⁱ	Q0GK43, baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
growth factor activity Source: UniProtKB-KW
interleukin-2 receptor binding Source: Ensembl
kappa-type opioid receptor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Chemistry databases

BindingDBⁱ	Q0GK43

BindingDBⁱ

Q0GK43

Structureⁱ

3D structure databases

SMRⁱ	Q0GK43
ModBaseⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	76 – 96	Sequence analysisAdd BLAST		21

Sequence similaritiesⁱ

Belongs to the IL-2 family.UniRule annotationARBA annotation

Keywords - Domainⁱ

Coiled coilSequence analysis, SignalUniRule annotation

Phylogenomic databases

HOGENOMⁱ	CLU_124210_0_0_1
OMAⁱ	FCQSIFS
Database of Orthologous Groups More...OrthoDBⁱ	1491449at2759

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000779, IL-2 IPR030477, IL-2_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00715, IL2, 1 hit
PRINTSⁱ	PR00265, INTERLEUKIN2
SMARTⁱ	View protein in SMART SM00189, IL2, 1 hit
SUPFAMⁱ	SSF47266, SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00424, INTERLEUKIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q0GK43-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN 
        60         70         80         90        100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL 
       110        120        130        140        150
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS 

TLT

Length:153

Mass (Da):17,628

Last modified:October 3, 2006 - v1

Checksum:ⁱ59E2F40F25860F84

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ861285 mRNA Translation: ABI20697.1 AB451325 mRNA Translation: BAG70139.1 AB451454 mRNA Translation: BAG70268.1 CH471056 Genomic DNA Translation: EAX05227.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000577.2, NM_000586.3

Genome annotation databases

GeneIDⁱ	3558
KEGGⁱ	hsa:3558
UCSC genome browser More...UCSCⁱ	uc003ier.4, human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q0GK43	Interleukin-2	)	HUMAN		153	UniRef100_P60568
Interleukin-2		HYLLA		153
Interleukin-2		PONAB		153
Interleukin-2		PANTR		153
Interleukin-2		PANPA		153
+5

Protein	Similar proteins		Species	Score	Length	Source
Q0GK43	Interleukin-2	)	HUMAN		153	UniRef90_P60568
Interleukin-2		HYLLA		153
Interleukin-2		MACMU		154
Interleukin-2		MACNE		154
Interleukin-2		SAISC		154
+37

Protein	Similar proteins		Species	Score	Length	Source
Q0GK43	Interleukin-2	)	HUMAN		153	UniRef50_P60568
Interleukin-2		HYLLA		153
Interleukin-2		CERAT		154
Interleukin-2		SAISC		154
Interleukin-2		MACFA		154
+268

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ861285 mRNA Translation: ABI20697.1 AB451325 mRNA Translation: BAG70139.1 AB451454 mRNA Translation: BAG70268.1 CH471056 Genomic DNA Translation: EAX05227.1
RefSeqⁱ	NP_000577.2, NM_000586.3

3D structure databases

SMRⁱ	Q0GK43
ModBaseⁱ	Search...

Chemistry databases

BindingDBⁱ	Q0GK43

BindingDBⁱ

Q0GK43

Protocols and materials databases

Antibodypediaⁱ	4147, 2084 antibodies
The DNASU plasmid repository More...DNASUⁱ	3558

Genome annotation databases

GeneIDⁱ	3558
KEGGⁱ	hsa:3558
UCSCⁱ	uc003ier.4, human

Organism-specific databases

CTDⁱ	3558
PharmGKBⁱ	PA195
VEuPathDBⁱ	HostDB:ENSG00000109471.4

Phylogenomic databases

HOGENOMⁱ	CLU_124210_0_0_1
OMAⁱ	FCQSIFS
OrthoDBⁱ	1491449at2759

Miscellaneous databases

BioGRID-ORCSⁱ	3558, 3 hits in 981 CRISPR screens
ChiTaRSⁱ	IL2, human
GenomeRNAiⁱ	3558

Gene expression databases

Bgeeⁱ	ENSG00000109471, Expressed in small intestine Peyer's patch and 76 other tissues
ExpressionAtlasⁱ	Q0GK43, baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000779, IL-2 IPR030477, IL-2_CS
Pfamⁱ	View protein in Pfam PF00715, IL2, 1 hit
PRINTSⁱ	PR00265, INTERLEUKIN2
SMARTⁱ	View protein in SMART SM00189, IL2, 1 hit
SUPFAMⁱ	SSF47266, SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00424, INTERLEUKIN_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q0GK43_HUMAN
Accessionⁱ	Q0GK43Primary (citable) accession number: Q0GK43
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 3, 2006
	Last sequence update:	October 3, 2006
	Last modified:	June 2, 2021
	This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Supporting data

UniProtKB - Q0GK43 (Q0GK43_HUMAN)

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Interleukin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ