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Protein

Serine/threonine-protein kinase STK11

Gene

STK11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78ATPPROSITE-ProRule annotationBy similarity1
Active sitei176Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi55 – 63ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Cell cycle, DNA damage
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-380972 Energy dependent regulation of mTOR by LKB1-AMPK

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase STK11 (EC:2.7.11.1)
Alternative name(s):
Liver kinase B1 homolog
Short name:
LKB1
Gene namesi
Name:STK11Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600331 – 440Serine/threonine-protein kinase STK11Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336Phosphothreonine; by autocatalysisBy similarity1
Modified residuei365Phosphothreonine; by autocatalysisBy similarity1
Modified residuei435Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0GGW5
PRIDEiQ0GGW5

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues tested. High levels were observed in duodenum and skeletal muscle, lower levels in liver and pancreas.1 Publication

Interactioni

Subunit structurei

Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004239

Structurei

3D structure databases

ProteinModelPortaliQ0GGW5
SMRiQ0GGW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 309Protein kinasePROSITE-ProRule annotationAdd BLAST261

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063214
HOGENOMiHOG000007002
HOVERGENiHBG054467
InParanoidiQ0GGW5
KOiK07298
PhylomeDBiQ0GGW5

Family and domain databases

CDDicd14119 STKc_LKB1, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR039154 LKB1_c
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q0GGW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMQESQQLG MFGESELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL
60 70 80 90 100
MGDLLGEGSY GKVKEMLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ
110 120 130 140 150
LLRRLRHKNV IQLVDVLYNE EKQKMYMVME YCVCGMQEML DSVPEKRFPV
160 170 180 190 200
FQAHGYFCQL IDGLEYLHSQ GIVHKDIKPG NLLLTTNGTL KISDLGVAEA
210 220 230 240 250
LHPFAEDDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS AGVTLYNITT
260 270 280 290 300
GLYPFEGDNI YKLFENIGKG DFTIPEDCGP PLSDLLRGML EYDPAKRFSI
310 320 330 340 350
QQIRQHNWFR KKHAQAETLV PIPPSPETKD KWRSMTAVPY LEDLHGYNED
360 370 380 390 400
EDDDLYDIED DIIYTQDFTV PGQVPEEEAG QNGQSRGRGL PKAICMNGTE
410 420 430 440
PGQLSTKSKA ERRASASSNP SRKACSASSK IRKLSTCKQQ
Length:440
Mass (Da):49,793
Last modified:October 3, 2006 - v1
Checksum:iEE79DB8129E4770A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ864976 mRNA Translation: ABI23430.1
RefSeqiNP_001039298.1, NM_001045833.1
UniGeneiGga.12596

Genome annotation databases

EnsembliENSGALT00000067287; ENSGALP00000055443; ENSGALG00000040008
GeneIDi420105
KEGGigga:420105

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ864976 mRNA Translation: ABI23430.1
RefSeqiNP_001039298.1, NM_001045833.1
UniGeneiGga.12596

3D structure databases

ProteinModelPortaliQ0GGW5
SMRiQ0GGW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004239

Proteomic databases

PaxDbiQ0GGW5
PRIDEiQ0GGW5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000067287; ENSGALP00000055443; ENSGALG00000040008
GeneIDi420105
KEGGigga:420105

Organism-specific databases

CTDi6794

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063214
HOGENOMiHOG000007002
HOVERGENiHBG054467
InParanoidiQ0GGW5
KOiK07298
PhylomeDBiQ0GGW5

Enzyme and pathway databases

ReactomeiR-GGA-380972 Energy dependent regulation of mTOR by LKB1-AMPK

Miscellaneous databases

PROiPR:Q0GGW5

Family and domain databases

CDDicd14119 STKc_LKB1, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR039154 LKB1_c
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTK11_CHICK
AccessioniPrimary (citable) accession number: Q0GGW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: October 3, 2006
Last modified: October 10, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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