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Entry version 124 (02 Dec 2020)
Sequence version 2 (28 Feb 2018)
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Protein

Sodium/bile acid cotransporter 7

Gene

SLC10A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:30082715, PubMed:29878199). Also involved in the regulation of cellular calcium homeostasis (PubMed:30082715, PubMed:31191616). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q0GE19

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.28.3.1, the bile acid:na(+) symporter (bass) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/bile acid cotransporter 7
Alternative name(s):
Na(+)/bile acid cotransporter 7
Solute carrier family 10 member 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC10A7
Synonyms:C4orf13, P7
ORF Names:PSEC0051
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000120519.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23088, SLC10A7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611459, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q0GE19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10Cytoplasmic1 Publication10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 37Extracellular1 Publication6
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 71Cytoplasmic1 PublicationAdd BLAST13
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93 – 116Extracellular1 PublicationAdd BLAST24
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138Cytoplasmic1 Publication1
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 163Extracellular1 Publication4
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 201Cytoplasmic1 PublicationAdd BLAST17
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 234Extracellular1 PublicationAdd BLAST12
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 270Cytoplasmic1 PublicationAdd BLAST15
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 298Extracellular1 Publication7
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 340Cytoplasmic1 PublicationAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis (SSASKS)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by disproportionate short stature, defective tooth enamel formation, and skeletal dysplasia with severe scoliosis in some patients. Variable features include facial dysmorphism, hearing impairment, and mildly impaired intellectual development.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08205674L → P in SSASKS; decreased protein levels; decreased expression at the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1560980659EnsemblClinVar.1
Natural variantiVAR_082057112G → D in SSASKS. 1 PublicationCorresponds to variant dbSNP:rs1560973571EnsemblClinVar.1
Natural variantiVAR_082058130G → R in SSASKS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1560973467EnsemblClinVar.1
Natural variantiVAR_082059185 – 340Missing in SSASKS. 1 PublicationAdd BLAST156
Natural variantiVAR_082060303P → L in SSASKS; mild skeletal features; results in altered regulation of calcium homeostasis and abnormal distribution of cellular calcium in patient fibroblasts. 1 Publication1

Keywords - Diseasei

Amelogenesis imperfecta, Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
84068

MalaCards human disease database

More...
MalaCardsi
SLC10A7
MIMi618363, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000120519

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162403478

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q0GE19, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC10A7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121946408

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002782501 – 340Sodium/bile acid cotransporter 7Add BLAST340

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q0GE19

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q0GE19

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q0GE19

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0GE19

PeptideAtlas

More...
PeptideAtlasi
Q0GE19

PRoteomics IDEntifications database

More...
PRIDEi
Q0GE19

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58749 [Q0GE19-1]
58750 [Q0GE19-2]
58751 [Q0GE19-3]
58752 [Q0GE19-4]
58753 [Q0GE19-5]
58754 [Q0GE19-6]
58755 [Q0GE19-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0GE19

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0GE19

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:15932064, PubMed:17628207). Expressed at high levels in liver and at lower levels in prostate, placenta, kidney, heart, lung, thymus and spleen (PubMed:15932064, PubMed:17628207). Strongly expressed in testis and also detected in brain, ovary, colon and small intestine (PubMed:17628207). Weakly expressed in testis and not detected in brain, ovary, colon or small intestine (PubMed:15932064). Isoform 1: Expressed in liver, testis and placenta (PubMed:17628207). Isoform 4: Expressed in liver, testis and placenta (PubMed:17628207).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in the heart and vertebrae in embryos at 8 weeks of gestation (Carnegie stage 16), and in the long-bone cartilage at 9 weeks (Carnegie stages 19).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120519, Expressed in colon and 195 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q0GE19, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000120519, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123863, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q0GE19, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000421275

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q0GE19, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4821, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011932

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039013_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0GE19

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFFYGLK

Database of Orthologous Groups

More...
OrthoDBi
949808at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0GE19

TreeFam database of animal gene trees

More...
TreeFami
TF329411

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038770, Na+/solute_symporter_sf
IPR016833, Put_Na-Bile_cotransptr

The PANTHER Classification System

More...
PANTHERi
PTHR18640, PTHR18640, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13593, SBF_like, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF026166, UCP026166, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: Q0GE19-2) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI
60 70 80 90 100
FFNSGLSLKT EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI
110 120 130 140 150
NEWLLKGLQT VGCMPPPVSS AVILTKAVGG NEAAAIFNSA FGSFLGIVIT
160 170 180 190 200
PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP LIIGQIVRRY IKDWLERKKP
210 220 230 240 250
PFGAISSSVL LMIIYTTFCD TFSNPNIDLD KFSLVLILFI IFSIQLSFML
260 270 280 290 300
LTFIFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI
310 320 330 340
SVPLLIYHPA QILLGSVLVP TIKSWMVSRQ KGVKLTRPTV
Length:340
Mass (Da):37,432
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9D4F4FFAF6DC9DF
GO
Isoform 1 (identifier: Q0GE19-1) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     332-340: GVKLTRPTV → KLLQTRGPLANLNNPEGLEYLSIKFGH

Show »
Length:358
Mass (Da):39,485
Checksum:iD23352F5F3990822
GO
Isoform 3 (identifier: Q0GE19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-145: Missing.

Show »
Length:327
Mass (Da):36,134
Checksum:i865D59F098CD5C7C
GO
Isoform 4 (identifier: Q0GE19-4) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     186-186: I → E
     187-340: Missing.

Show »
Length:186
Mass (Da):20,093
Checksum:i6B62BA3395691D22
GO
Isoform 5 (identifier: Q0GE19-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-159: GIVITPLLLLLFLG → VSKHSLTCLLQLLL
     160-340: Missing.

Show »
Length:159
Mass (Da):17,283
Checksum:iF92AC92F76B5F229
GO
Isoform 6 (identifier: Q0GE19-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: E → L
     65-340: Missing.

Show »
Length:64
Mass (Da):6,978
Checksum:i14DD8861CECDB2CF
GO
Isoform 7 (identifier: Q0GE19-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-85: ELTSALVHLKLHLFIQIFTLAFFP → FADSRLHASACVFCSDFNQGSWWK
     86-340: Missing.

Show »
Length:85
Mass (Da):9,396
Checksum:iDA0C615FA70F592B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11571 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti296H → Y in BAC11571 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08205674L → P in SSASKS; decreased protein levels; decreased expression at the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1560980659EnsemblClinVar.1
Natural variantiVAR_082057112G → D in SSASKS. 1 PublicationCorresponds to variant dbSNP:rs1560973571EnsemblClinVar.1
Natural variantiVAR_082058130G → R in SSASKS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1560973467EnsemblClinVar.1
Natural variantiVAR_082059185 – 340Missing in SSASKS. 1 PublicationAdd BLAST156
Natural variantiVAR_082060303P → L in SSASKS; mild skeletal features; results in altered regulation of calcium homeostasis and abnormal distribution of cellular calcium in patient fibroblasts. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02321562 – 85ELTSA…LAFFP → FADSRLHASACVFCSDFNQG SWWK in isoform 7. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_02321662E → L in isoform 6. 1 Publication1
Alternative sequenceiVSP_02321765 – 340Missing in isoform 6. 1 PublicationAdd BLAST276
Alternative sequenceiVSP_02321886 – 340Missing in isoform 7. 1 PublicationAdd BLAST255
Alternative sequenceiVSP_023219133 – 145Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_023220146 – 159GIVIT…LLFLG → VSKHSLTCLLQLLL in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_023221160 – 340Missing in isoform 5. 1 PublicationAdd BLAST181
Alternative sequenceiVSP_023222186I → E in isoform 4. 1 Publication1
Alternative sequenceiVSP_023223187 – 340Missing in isoform 4. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_059321332 – 340GVKLTRPTV → KLLQTRGPLANLNNPEGLEY LSIKFGH in isoform 1. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY346324 mRNA Translation: AAQ84722.1
DQ122860 mRNA Translation: AAZ32256.1
DQ122861 mRNA Translation: AAZ32257.1
DQ871036 mRNA Translation: ABI31650.1
CR933647 mRNA Translation: CAI45948.1
CH471056 Genomic DNA Translation: EAX05026.1
BC023288 mRNA Translation: AAH23288.1
BC063471 mRNA Translation: AAH63471.1
BC120971 mRNA Translation: AAI20972.1
BC127626 mRNA Translation: AAI27627.1
BC127627 mRNA Translation: AAI27628.1
BC120970 mRNA Translation: AAI20971.1
BC148252 mRNA Translation: AAI48253.1
BC150308 mRNA Translation: AAI50309.1
AL136728 mRNA Translation: CAB66662.2
AK075364 mRNA Translation: BAC11571.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS34073.1 [Q0GE19-2]
CCDS3768.1 [Q0GE19-5]
CCDS75198.1 [Q0GE19-1]
CCDS82962.1 [Q0GE19-7]
CCDS82963.1 [Q0GE19-3]
CCDS82964.1 [Q0GE19-6]

NCBI Reference Sequences

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RefSeqi
NP_001025169.1, NM_001029998.5 [Q0GE19-2]
NP_001287771.1, NM_001300842.2 [Q0GE19-1]
NP_001304745.1, NM_001317816.1 [Q0GE19-3]
NP_001304746.1, NM_001317817.1 [Q0GE19-7]
NP_001304747.1, NM_001317818.1 [Q0GE19-6]
NP_115504.1, NM_032128.4 [Q0GE19-5]
XP_016864181.1, XM_017008692.1 [Q0GE19-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000335472; ENSP00000334594; ENSG00000120519 [Q0GE19-2]
ENST00000394059; ENSP00000377623; ENSG00000120519 [Q0GE19-5]
ENST00000432059; ENSP00000411297; ENSG00000120519 [Q0GE19-3]
ENST00000502607; ENSP00000422577; ENSG00000120519 [Q0GE19-6]
ENST00000507030; ENSP00000421275; ENSG00000120519 [Q0GE19-1]
ENST00000511374; ENSP00000421603; ENSG00000120519 [Q0GE19-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84068

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84068

UCSC genome browser

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UCSCi
uc003ikr.3, human [Q0GE19-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY346324 mRNA Translation: AAQ84722.1
DQ122860 mRNA Translation: AAZ32256.1
DQ122861 mRNA Translation: AAZ32257.1
DQ871036 mRNA Translation: ABI31650.1
CR933647 mRNA Translation: CAI45948.1
CH471056 Genomic DNA Translation: EAX05026.1
BC023288 mRNA Translation: AAH23288.1
BC063471 mRNA Translation: AAH63471.1
BC120971 mRNA Translation: AAI20972.1
BC127626 mRNA Translation: AAI27627.1
BC127627 mRNA Translation: AAI27628.1
BC120970 mRNA Translation: AAI20971.1
BC148252 mRNA Translation: AAI48253.1
BC150308 mRNA Translation: AAI50309.1
AL136728 mRNA Translation: CAB66662.2
AK075364 mRNA Translation: BAC11571.1 Different initiation.
CCDSiCCDS34073.1 [Q0GE19-2]
CCDS3768.1 [Q0GE19-5]
CCDS75198.1 [Q0GE19-1]
CCDS82962.1 [Q0GE19-7]
CCDS82963.1 [Q0GE19-3]
CCDS82964.1 [Q0GE19-6]
RefSeqiNP_001025169.1, NM_001029998.5 [Q0GE19-2]
NP_001287771.1, NM_001300842.2 [Q0GE19-1]
NP_001304745.1, NM_001317816.1 [Q0GE19-3]
NP_001304746.1, NM_001317817.1 [Q0GE19-7]
NP_001304747.1, NM_001317818.1 [Q0GE19-6]
NP_115504.1, NM_032128.4 [Q0GE19-5]
XP_016864181.1, XM_017008692.1 [Q0GE19-7]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123863, 13 interactors
IntActiQ0GE19, 11 interactors
STRINGi9606.ENSP00000421275

Protein family/group databases

TCDBi2.A.28.3.1, the bile acid:na(+) symporter (bass) family

PTM databases

iPTMnetiQ0GE19
PhosphoSitePlusiQ0GE19

Polymorphism and mutation databases

BioMutaiSLC10A7
DMDMi121946408

Proteomic databases

EPDiQ0GE19
jPOSTiQ0GE19
MassIVEiQ0GE19
PaxDbiQ0GE19
PeptideAtlasiQ0GE19
PRIDEiQ0GE19
ProteomicsDBi58749 [Q0GE19-1]
58750 [Q0GE19-2]
58751 [Q0GE19-3]
58752 [Q0GE19-4]
58753 [Q0GE19-5]
58754 [Q0GE19-6]
58755 [Q0GE19-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27520, 91 antibodies

The DNASU plasmid repository

More...
DNASUi
84068

Genome annotation databases

EnsembliENST00000335472; ENSP00000334594; ENSG00000120519 [Q0GE19-2]
ENST00000394059; ENSP00000377623; ENSG00000120519 [Q0GE19-5]
ENST00000432059; ENSP00000411297; ENSG00000120519 [Q0GE19-3]
ENST00000502607; ENSP00000422577; ENSG00000120519 [Q0GE19-6]
ENST00000507030; ENSP00000421275; ENSG00000120519 [Q0GE19-1]
ENST00000511374; ENSP00000421603; ENSG00000120519 [Q0GE19-7]
GeneIDi84068
KEGGihsa:84068
UCSCiuc003ikr.3, human [Q0GE19-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84068
DisGeNETi84068
EuPathDBiHostDB:ENSG00000120519.14

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC10A7
HGNCiHGNC:23088, SLC10A7
HPAiENSG00000120519, Low tissue specificity
MalaCardsiSLC10A7
MIMi611459, gene
618363, phenotype
neXtProtiNX_Q0GE19
OpenTargetsiENSG00000120519
PharmGKBiPA162403478

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4821, Eukaryota
GeneTreeiENSGT00390000011932
HOGENOMiCLU_039013_0_0_1
InParanoidiQ0GE19
OMAiFFFYGLK
OrthoDBi949808at2759
PhylomeDBiQ0GE19
TreeFamiTF329411

Enzyme and pathway databases

PathwayCommonsiQ0GE19

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84068, 11 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC10A7, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC10A7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84068
PharosiQ0GE19, Tdark

Protein Ontology

More...
PROi
PR:Q0GE19
RNActiQ0GE19, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120519, Expressed in colon and 195 other tissues
GenevisibleiQ0GE19, HS

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR038770, Na+/solute_symporter_sf
IPR016833, Put_Na-Bile_cotransptr
PANTHERiPTHR18640, PTHR18640, 1 hit
PfamiView protein in Pfam
PF13593, SBF_like, 1 hit
PIRSFiPIRSF026166, UCP026166, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTCP7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0GE19
Secondary accession number(s): A7E2E6
, A7MAX9, Q0VAP9, Q45NG1, Q45NG2, Q5H9S6, Q6P4E6, Q8IZ62, Q8NBP8, Q9H0M9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 28, 2018
Last modified: December 2, 2020
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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