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UniProtKB - Q0GBZ5 (OX1R_BOVIN)
Protein
Orexin/Hypocretin receptor type 1
Gene
HCRTR1
Organism
Bos taurus (Bovine)
Status
Functioni
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 36 | Important for responses to orexinBy similarity | 1 |
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- orexin receptor activity Source: UniProtKB
GO - Biological processi
- feeding behavior Source: InterPro
- G protein-coupled receptor signaling pathway Source: GO_Central
- neuropeptide signaling pathway Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- regulation of cytosolic calcium ion concentration Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Orexin/Hypocretin receptor type 1By similarity |
Gene namesi | Name:HCRTR1By similarity |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000010366 |
VGNCi | VGNC:29781, HCRTR1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 46 | ExtracellularBy similarityAdd BLAST | 46 | |
Transmembranei | 47 – 67 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 68 – 82 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 83 – 105 | Helical; Name=2By similarityAdd BLAST | 23 | |
Topological domaini | 106 – 119 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 120 – 140 | Helical; Name=3By similarityAdd BLAST | 21 | |
Topological domaini | 141 – 160 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 161 – 182 | Helical; Name=4By similarityAdd BLAST | 22 | |
Topological domaini | 183 – 213 | ExtracellularBy similarityAdd BLAST | 31 | |
Transmembranei | 214 – 235 | Helical; Name=5By similarityAdd BLAST | 22 | |
Topological domaini | 236 – 298 | CytoplasmicBy similarityAdd BLAST | 63 | |
Transmembranei | 299 – 321 | Helical; Name=6By similarityAdd BLAST | 23 | |
Topological domaini | 322 – 336 | ExtracellularBy similarityAdd BLAST | 15 | |
Transmembranei | 337 – 360 | Helical; Name=7By similarityAdd BLAST | 24 | |
Topological domaini | 361 – 425 | CytoplasmicBy similarityAdd BLAST | 65 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000269712 | 1 – 425 | Orexin/Hypocretin receptor type 1Add BLAST | 425 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 119 ↔ 202 | By similarity | ||
Glycosylationi | 194 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q0GBZ5 |
PRIDEi | Q0GBZ5 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000010366, Expressed in bone marrow and 80 other tissues |
ExpressionAtlasi | Q0GBZ5, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 26 – 41 | Required for response to orexin-ABy similarityAdd BLAST | 16 |
Domaini
The N-terminal region is required for orexin signaling.By similarity
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230390 |
HOGENOMi | CLU_009579_6_3_1 |
InParanoidi | Q0GBZ5 |
OMAi | LMEPSAT |
OrthoDBi | 981089at2759 |
TreeFami | TF315303 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000204, Orexin_rcpt IPR004059, Orexin_rcpt_1 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01521, OREXIN1R PR01064, OREXINR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q0GBZ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPSATPGPQ MGVPTEGRER SPEPPDYEDE FLRYLWRDYL YPKQYEWVLI
60 70 80 90 100
AAYVAVFFVA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL
110 120 130 140 150
PASLLVDITE SWLFGHALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH
160 170 180 190 200
PLLFKSTARR ARGSILGIWA VSLAVMVPQA AVMECSSVLP ELANRTRLFS
210 220 230 240 250
VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR KLWGRQIPGT
260 270 280 290 300
TSALVRNWKR PSVQLEEQGQ GLGAEPQPRA RAFLAEVKQM RARRKTAKML
310 320 330 340 350
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN
360 370 380 390 400
SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPCVSLKVPS PRSSASHKSL
410 420
SLQSRCSVSK ASEHVLLTSV TTVLP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A452DID0 | A0A452DID0_BOVIN | Orexin receptor type 1 | HCRTR1 | 402 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ874350 mRNA Translation: ABI34075.1 |
RefSeqi | NP_001041647.1, NM_001048182.1 |
Genome annotation databases
Ensembli | ENSBTAT00000076106; ENSBTAP00000062326; ENSBTAG00000010366 |
GeneIDi | 282248 |
KEGGi | bta:282248 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ874350 mRNA Translation: ABI34075.1 |
RefSeqi | NP_001041647.1, NM_001048182.1 |
3D structure databases
SMRi | Q0GBZ5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000013687 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PaxDbi | Q0GBZ5 |
PRIDEi | Q0GBZ5 |
Genome annotation databases
Ensembli | ENSBTAT00000076106; ENSBTAP00000062326; ENSBTAG00000010366 |
GeneIDi | 282248 |
KEGGi | bta:282248 |
Organism-specific databases
CTDi | 3061 |
VEuPathDBi | HostDB:ENSBTAG00000010366 |
VGNCi | VGNC:29781, HCRTR1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230390 |
HOGENOMi | CLU_009579_6_3_1 |
InParanoidi | Q0GBZ5 |
OMAi | LMEPSAT |
OrthoDBi | 981089at2759 |
TreeFami | TF315303 |
Gene expression databases
Bgeei | ENSBTAG00000010366, Expressed in bone marrow and 80 other tissues |
ExpressionAtlasi | Q0GBZ5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000204, Orexin_rcpt IPR004059, Orexin_rcpt_1 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01521, OREXIN1R PR01064, OREXINR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OX1R_BOVIN | |
Accessioni | Q0GBZ5Primary (citable) accession number: Q0GBZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | October 3, 2006 | |
Last modified: | September 29, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families