UniProtKB - Q0E8S4 (Q0E8S4_DROME)
Protein
Submitted name:
Semaphorin 1a, isoform D
Gene
Sema1a
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- semaphorin receptor binding Source: InterPro
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- nervous system development Source: UniProtKB-KW
Keywordsi
Biological process | DifferentiationARBA annotation, NeurogenesisARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Semaphorin 1a, isoform DImportedSubmitted name: Semaphorin 1a, isoform EImported |
Gene namesi | Name:Sema1aImported Synonyms:BcDNA:RE36155Imported, CT26404Imported, D-Sema 1aImported, D-Sema IImported, d-sema IImported, D-Sema-IImported, D-SemaIImported, D-semaIImported, d-semaIImported, Dmel\CG18405Imported, Dsema 1aImported, Dsema-IImported, Fas-IVImported, FasIVImported, l(2)k13702Imported, semaImported, Sema 1aImported, sema 1aImported, SEMA-1AImported, Sema-1aImported, sema-1aImported, Sema-IImported, sema-IImported, Sema1AImported, sema1aImported, SemaIImported ORF Names:CG18405Imported, Dmel_CG18405Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0011259, Sema1a |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 44 – 62 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 663 – 685 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
PRIDEi | Q0E8S4 |
Expressioni
Gene expression databases
Bgeei | FBgn0011259, Expressed in central nervous system and 39 other tissues |
Interactioni
GO - Molecular functioni
- semaphorin receptor binding Source: InterPro
Protein-protein interaction databases
IntActi | Q0E8S4, 106 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 543 | SemaInterPro annotationAdd BLAST | 470 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 741 – 772 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 804 – 905 | DisorderedSequence analysisAdd BLAST | 102 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 813 – 836 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 847 – 884 | PolarSequence analysisAdd BLAST | 38 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000167882 |
Family and domain databases
CDDi | cd11237, Sema_1A, 1 hit |
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR002165, Plexin_repeat IPR016201, PSI IPR042068, SEM1A_sema_dom IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR027231, Semaphorin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR11036, PTHR11036, 1 hit |
Pfami | View protein in Pfam PF01437, PSI, 1 hit PF01403, Sema, 1 hit |
SMARTi | View protein in SMART SM00423, PSI, 1 hit SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q0E8S4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNSHNTNHN NNSASNSNYN KGHKMHLKSA TAKATIMKHK LSKFYGYGWM
60 70 80 90 100
QVFLLLTVLV IGNQSAWQEN IRPKLYVELG PEDVLKFVGN ESVVDHFKLV
110 120 130 140 150
TKDGNSLLIG ARNTVFNLSI HDLVEQQRLV WTSPEDDTKM CLVKGKDEEA
160 170 180 190 200
CQNYIRIMVV PSPGRLFVCG TNSFRPMCNT YIISDSNYTL EATKNGQAVC
210 220 230 240 250
PYDPRHNSTS VLADNELYSG TVADFSGSDP IIYREPLQTE QYDSLSLNAP
260 270 280 290 300
NFVSSFTQGD FVYFFFRETA VEFINCGKAI YSRVARVCKW DKGGPHRFRN
310 320 330 340 350
RWTSFLKSRL NCSIPGDYPF YFNEIQSASN LVEGQYGSMS SKLIYGVFNT
360 370 380 390 400
PSNSIPGSAV CAFALQDIAD TFEGQFKEQT GINSNWLPVN NAKVPDPRPG
410 420 430 440 450
SCHNDSRALP DPTLNFIKTH SLMDENVPAF FSQPILVRTS TIYRFTQIAV
460 470 480 490 500
DAQIKTPGGK TYDVIFVGTD HGKIIKSVNA ESADSADKVT SVVIEEIDVL
510 520 530 540 550
TKSEPIRNLE IVRTMQYDQP KDGSYDDGKL IIVTDSQVVA IQLHRCHNDK
560 570 580 590 600
ITSCSECVAL QDPYCAWDKI AGKCRSHGAP RWLEENYFYQ NVATGQHAAC
610 620 630 640 650
PSGKINSKDA NAGEQKGFRN DMDLLDSRRQ SKDQEIIDNI DKNFEGPQIS
660 670 680 690 700
ADIINAQYTV ETLVMAVLAG SIFSLLVGFF TGYFCGRRCH KDEDDNLPYP
710 720 730 740 750
DTEYEYFEQR QNVNSFPSSC RIQQEPKLLP QVEEVTYAEP VLLPQPPPPN
760 770 780 790 800
KMHSPKNTLR KPPMHQMHQG PNSETLFQFQ PDGYNTQQSY RGRDNFGTLR
810 820 830 840 850
SHQVMGDNYR RGDGFSTTRS VKKAVNNTNT RNRSLGRARR QPPRHGIVTQ
860 870 880 890 900
HRSNSPQQQQ QQSQQPHSSS GSSPVMSNSS SSPAPPSSSP SPQESPKNCS
YIYRD
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ24322 | SEM1A_DROME | Semaphorin-1A | Sema1a Dsema-I, Sema-1a, CG18405 | 899 | Annotation score: | ||
M9PCL7 | M9PCL7_DROME | Semaphorin 1a, isoform G | Sema1a BcDNA:RE36155, CT26404, D-Sema 1a, D-Sema I, d-sema I | 1,131 | Annotation score: | ||
M9PB77 | M9PB77_DROME | Semaphorin 1a, isoform I | Sema1a BcDNA:RE36155, CT26404, D-Sema 1a, D-Sema I, d-sema I | 817 | Annotation score: | ||
M9PFA5 | M9PFA5_DROME | Semaphorin 1a, isoform H | Sema1a BcDNA:RE36155, CT26404, D-Sema 1a, D-Sema I, d-sema I | 820 | Annotation score: | ||
M9MRI2 | M9MRI2_DROME | Semaphorin 1a, isoform F | Sema1a BcDNA:RE36155, CT26404, D-Sema 1a, D-Sema I, d-sema I | 826 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAN10677.3 AE014134 Genomic DNA Translation: ADV36981.1 |
RefSeqi | NP_001188731.1, NM_001201802.2 NP_609243.3, NM_135399.5 |
Genome annotation databases
EnsemblMetazoai | FBtr0303877; FBpp0292880; FBgn0011259 FBtr0303878; FBpp0292881; FBgn0011259 |
GeneIDi | 34192 |
UCSCi | CG18405-RB, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAN10677.3 AE014134 Genomic DNA Translation: ADV36981.1 |
RefSeqi | NP_001188731.1, NM_001201802.2 NP_609243.3, NM_135399.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q0E8S4, 106 interactors |
Proteomic databases
PRIDEi | Q0E8S4 |
Genome annotation databases
EnsemblMetazoai | FBtr0303877; FBpp0292880; FBgn0011259 FBtr0303878; FBpp0292881; FBgn0011259 |
GeneIDi | 34192 |
UCSCi | CG18405-RB, d. melanogaster |
Organism-specific databases
CTDi | 34192 |
FlyBasei | FBgn0011259, Sema1a |
Phylogenomic databases
GeneTreei | ENSGT00940000167882 |
Miscellaneous databases
BioGRID-ORCSi | 34192, 0 hits in 3 CRISPR screens |
ChiTaRSi | Sema-1a, fly |
GenomeRNAii | 34192 |
Gene expression databases
Bgeei | FBgn0011259, Expressed in central nervous system and 39 other tissues |
Family and domain databases
CDDi | cd11237, Sema_1A, 1 hit |
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR002165, Plexin_repeat IPR016201, PSI IPR042068, SEM1A_sema_dom IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR027231, Semaphorin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR11036, PTHR11036, 1 hit |
Pfami | View protein in Pfam PF01437, PSI, 1 hit PF01403, Sema, 1 hit |
SMARTi | View protein in SMART SM00423, PSI, 1 hit SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q0E8S4_DROME | |
Accessioni | Q0E8S4Primary (citable) accession number: Q0E8S4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 17, 2006 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |