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Entry version 119 (11 Dec 2019)
Sequence version 1 (17 Oct 2006)
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Protein
Submitted name:

Simjang, isoform A

Gene

simj

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Simjang, isoform AImported
Submitted name:
Simjang, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:simjImported
Synonyms:68-likeImported, anon-WO0118547.361Imported, CG7983Imported, CG8000Imported, Dmel\CG32067Imported, dp66Imported, l(3)01814Imported, l(3)j4A5Imported, l(3)rN672Imported, p66Imported, SIMJImported
ORF Names:CG32067Imported, Dmel_CG32067Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010762 simj

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010762 Expressed in 24 organ(s), highest expression level in eye disc (Drosophila)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q0E8G1, 8 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini184 – 228P66_CCInterPro annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni14 – 35DisorderedSequence analysisAdd BLAST22
Regioni48 – 173DisorderedSequence analysisAdd BLAST126
Regioni249 – 290DisorderedSequence analysisAdd BLAST42
Regioni338 – 428DisorderedSequence analysisAdd BLAST91
Regioni554 – 604DisorderedSequence analysisAdd BLAST51
Regioni619 – 731DisorderedSequence analysisAdd BLAST113
Regioni860 – 916DisorderedSequence analysisAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili183 – 213Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi48 – 122PolarSequence analysisAdd BLAST75
Compositional biasi126 – 140PolyampholyteSequence analysisAdd BLAST15
Compositional biasi338 – 405PolarSequence analysisAdd BLAST68
Compositional biasi554 – 595PolarSequence analysisAdd BLAST42
Compositional biasi627 – 645Pro-richSequence analysisAdd BLAST19
Compositional biasi687 – 720PolyampholyteSequence analysisAdd BLAST34
Compositional biasi860 – 885PolarSequence analysisAdd BLAST26
Compositional biasi896 – 916PolarSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3740 Eukaryota
ENOG410XRVM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004097

Database of Orthologous Groups

More...
OrthoDBi
765642at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040386 P66
IPR032346 P66_CC

The PANTHER Classification System

More...
PANTHERi
PTHR13455 PTHR13455, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16563 P66_CC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q0E8G1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKMEVDDVV DLSLGSGRDP ALTITPAPPP AALSNRDLRA LTANNAGLTI
60 70 80 90 100
TPSASPATNN GTTSNSSNTN SNSSSTTTTT NNNNNSSSNT NSSSANNNNN
110 120 130 140 150
NNSINASDGV TGATSGSIGG GQDENKVQRR VLRPRTEPKS YAEAPDIVLL
160 170 180 190 200
PARTNGRQQN GNIDSETDDE EMPPYVPIKE LSHAELKERE KSLRKLRQDL
210 220 230 240 250
RNEETKLMLL KKLKQSQQVM KENLVVTPTS VSPNNPLSAI PAALTSKGSL
260 270 280 290 300
SVTPTSAVPL PAHSKGSRSS LSGSGGPAVS ISATNSRTGS SSSAAAAASA
310 320 330 340 350
IAAAAMSGQH RSGSNSILPP PRSSLPAGAT LAAGTTITPA TSSSHRSSNL
360 370 380 390 400
PPRTNLPNLT ITPSVTITPT SAPPSSLKPR NVPGTISNSV SITPALPLSQ
410 420 430 440 450
SHQNQHNDQK NDRSTPREDA QTPAQRQAAA KMALRKQLEK TLLQIPPPKP
460 470 480 490 500
PPPEMHFIPN PSNTDFVYLL GLETVVDYLT VNKKANAVAA PFRCAQCKID
510 520 530 540 550
FTPVWKWEKQ TNKDPKVICE QCVTSNVKKA LKAEHTNRLK QAFVKALQQE
560 570 580 590 600
QEIEQRLASQ SSPSPVDNHG SSGGGNSLSV SAVSSNSSSS HMQREREQLQ
610 620 630 640 650
ASHASAAAAL VNLPPSVTVI PTKCQTPTPA TPRPTPPPPQ SQATPPPSSG
660 670 680 690 700
GSRSSRAAAT AAAAAIAAQQ AGILSPGPSP AHHHEPTTSS RSSRNDRLDH
710 720 730 740 750
HHQSQQQQQR DQRERDQQQR DQQSQQQAQN YDKYSAATLA AAAHLSALGG
760 770 780 790 800
MGGLNINSLA SLGNLGNLGN LSQLGNLAAL GGLGNFGGAS TGSANPAAGL
810 820 830 840 850
SGSSPAATAA AMQAFQQQLF RALGQGLGGN PQHMMQFAPL LYSYQMAMAQ
860 870 880 890 900
AAQVAAFNNN NKKSSSSSGS AKNSSSSNSM AEVQRAAELQ RQYLLEMIPP
910
QQQSGASGSR QNNWKA
Length:916
Mass (Da):95,753
Last modified:October 17, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA821EAA45E2B8306
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PET3M9PET3_DROME
Simjang, isoform D
simj 68-like, anon-WO0118547.361, CG7983, CG8000, Dmel\CG32067
924Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PF79M9PF79_DROME
Simjang, isoform E
simj 68-like, anon-WO0118547.361, CG7983, CG8000, Dmel\CG32067
937Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q960V1Q960V1_DROME
LD33361p
simj 68-like, anon-WO0118547.361, CG7983, CG8000, Dmel\CG32067
912Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50140.1
AE014296 Genomic DNA Translation: AAF50141.2

NCBI Reference Sequences

More...
RefSeqi
NP_729624.1, NM_168420.2
NP_729625.1, NM_168421.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0076262; FBpp0075991; FBgn0010762
FBtr0076263; FBpp0075992; FBgn0010762

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39212

UCSC genome browser

More...
UCSCi
CG32067-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50140.1
AE014296 Genomic DNA Translation: AAF50141.2
RefSeqiNP_729624.1, NM_168420.2
NP_729625.1, NM_168421.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ0E8G1, 8 interactors

Genome annotation databases

EnsemblMetazoaiFBtr0076262; FBpp0075991; FBgn0010762
FBtr0076263; FBpp0075992; FBgn0010762
GeneIDi39212
UCSCiCG32067-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39212
FlyBaseiFBgn0010762 simj

Phylogenomic databases

eggNOGiKOG3740 Eukaryota
ENOG410XRVM LUCA
GeneTreeiENSGT00390000004097
OrthoDBi765642at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
simj fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39212

Gene expression databases

BgeeiFBgn0010762 Expressed in 24 organ(s), highest expression level in eye disc (Drosophila)

Family and domain databases

InterProiView protein in InterPro
IPR040386 P66
IPR032346 P66_CC
PANTHERiPTHR13455 PTHR13455, 2 hits
PfamiView protein in Pfam
PF16563 P66_CC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ0E8G1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0E8G1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: December 11, 2019
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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