Os02g0815500

Functionⁱ

Catalytic activityⁱ

A primary alcohol + NAD⁺ = an aldehyde + NADH.By similarity

A secondary alcohol + NAD⁺ = a ketone + NADH.By similarity

S-(hydroxymethyl)glutathione + NAD(P)⁺ = S-formylglutathione + NAD(P)H.By similarity

Cofactorⁱ

Zn²⁺By similarityNote: Binds 2 Zn²⁺ ions per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	49	Zinc 1; catalyticBy similarity	1
Binding siteⁱ	50	NADBy similarity	1
Binding siteⁱ	51	SubstrateBy similarity	1
Metal bindingⁱ	71	Zinc 1; catalyticBy similarity	1
Binding siteⁱ	71	SubstrateBy similarity	1
Metal bindingⁱ	72	Zinc 1By similarity	1
Metal bindingⁱ	101	Zinc 2By similarity	1
Metal bindingⁱ	104	Zinc 2By similarity	1
Metal bindingⁱ	107	Zinc 2By similarity	1
Metal bindingⁱ	115	Zinc 2By similarity	1
Metal bindingⁱ	179	Zinc 1; catalyticBy similarity	1
Binding siteⁱ	228	NADBy similarity	1
Binding siteⁱ	233	NADBy similarity	1
Binding siteⁱ	274	NAD; via carbonyl oxygenBy similarity	1
Binding siteⁱ	374	NADBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	204 – 209	NADBy similarity	6
Nucleotide bindingⁱ	297 – 299	NADBy similarity	3
Nucleotide bindingⁱ	322 – 324	NADBy similarity	3

GO - Molecular functionⁱ

alcohol dehydrogenase (NAD) activity Source: UniProtKB-EC
S-(hydroxymethyl)glutathione dehydrogenase activity Source: UniProtKB-EC
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ethanol oxidation Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	Metal-binding, NAD, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-OSA-2161541 Abacavir metabolism R-OSA-5365859 RA biosynthesis pathway R-OSA-71384 Ethanol oxidation

Reactomeⁱ

R-OSA-2161541 Abacavir metabolism
R-OSA-5365859 RA biosynthesis pathway
R-OSA-71384 Ethanol oxidation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alcohol dehydrogenase class-3 (EC:1.1.1.1By similarity) Alternative name(s): Alcohol dehydrogenase class-III Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-) Short name: FALDH Short name: FDH Short name: GSH-FDH S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284By similarity)
Gene namesⁱ	Ordered Locus Names:Os02g0815500, LOC_Os02g57040 ORF Names:OsJ_008550, P0643F09.4
Organismⁱ	Oryza sativa subsp. japonica (Rice)
Taxonomic identifierⁱ	39947 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
Proteomesⁱ	UP000059680 Componentⁱ: Chromosome 2

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000160773	1 – 381	Alcohol dehydrogenase class-3Add BLAST		381

Proteomic databases

PaxDbⁱ	Q0DWH1
PRIDEⁱ	Q0DWH1

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	Q0DWH1 differential
Genevisibleⁱ	Q0DWH1 OS

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os02g57040.1

STRINGⁱ

39947.LOC_Os02g57040.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q0DWH1
SMRⁱ	Q0DWH1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0022 Eukaryota COG1062 LUCA
InParanoidⁱ	Q0DWH1
KEGG Orthology (KO) More...KOⁱ	K00121
OMAⁱ	CIGNVNT
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360BVQ

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08300 alcohol_DH_class_III, 1 hit
InterProⁱ	View protein in InterPro IPR014183 ADH_3 IPR013149 ADH_C IPR013154 ADH_N IPR002328 ADH_Zn_CS IPR011032 GroES-like_sf IPR036291 NAD(P)-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08240 ADH_N, 1 hit PF00107 ADH_zinc_N, 1 hit
SUPFAMⁱ	SSF50129 SSF50129, 2 hits SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR02818 adh_III_F_hyde, 1 hit
PROSITEⁱ	View protein in PROSITE PS00059 ADH_ZINC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q0DWH1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASSTQGQVI TCKAAVAWEA NRPMTIEDVQ VAPPQAGEVR VKILFTALCH 
        60         70         80         90        100
TDHYTWSGKD PEGLFPCILG HEAAGIVESV GEGVTEVQPG DHVIPCYQAE 
       110        120        130        140        150
CRECKFCKSG KTNLCGKVRA ATGVGVMMND RKSRFSINGK PIYHFMGTST 
       160        170        180        190        200
FSQYTVVHDV SVAKINPQAP LDKVCLLGCG VSTGLGAVWN TAKVEAGSIV 
       210        220        230        240        250
AIFGLGTVGL AVAEGAKSAG ASRIIGIDID SKKFDVAKNF GVTEFVNPKD 
       260        270        280        290        300
HDKPIQQVIV DLTDGGVDYS FECIGNVSVM RSALECCHKG WGTSVIVGVA 
       310        320        330        340        350
ASGQEISTRP FQLVTGRVWK GTAFGGFKSR SQVPWLVEKY LNKEIKVDEY 
       360        370        380 
VTHSMNLTDI NKAFDLLHEG GCLRCVLATD K

Length:381

Mass (Da):40,823

Last modified:October 17, 2006 - v1

Checksum:ⁱC107E6B8B2CB7F58

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	318	V → I in AK099733 (PubMed:12869764).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP004120 Genomic DNA Translation: BAD21676.1 AP005111 Genomic DNA Translation: BAD21999.1 AP008208 Genomic DNA Translation: BAF10417.1 AP014958 Genomic DNA Translation: BAS81559.1 CM000139 Genomic DNA Translation: EAZ25067.1 AK099733 mRNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_015627169.1, XM_015771683.1
UniGeneⁱ	Os.59290

Genome annotation databases

EnsemblPlantsⁱ	Os02t0815500-01; Os02t0815500-01; Os02g0815500
GeneIDⁱ	4331130
Grameneⁱ	Os02t0815500-01; Os02t0815500-01; Os02g0815500
KEGGⁱ	osa:4331130

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q0DWH1	Alcohol dehydrogenase class-3		MAIZE		381
S-(hydroxymethyl)glutathione dehydrogenase		Leersia perrieri		388
S-(hydroxymethyl)glutathione dehydrogenase		ORYPU		385
S-(hydroxymethyl)glutathione dehydrogenase		ORYRU		464
S-(hydroxymethyl)glutathione dehydrogenase		Oryza glumipatula		381
+83

Protein	Similar proteins		Species	Score	Length
Q0DWH1	Alcohol dehydrogenase class-3	)	HUMAN		374
UPI00064B25B7		SORAR		456
UPI0003BB9D17		MYOBR		395
UPI000CCC5FD8		MYOLU		389
UPI0003EC4532		MYODS		386
+559

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP004120 Genomic DNA Translation: BAD21676.1 AP005111 Genomic DNA Translation: BAD21999.1 AP008208 Genomic DNA Translation: BAF10417.1 AP014958 Genomic DNA Translation: BAS81559.1 CM000139 Genomic DNA Translation: EAZ25067.1 AK099733 mRNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_015627169.1, XM_015771683.1
UniGeneⁱ	Os.59290

3D structure databases

ProteinModelPortalⁱ	Q0DWH1
SMRⁱ	Q0DWH1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os02g57040.1

STRINGⁱ

39947.LOC_Os02g57040.1

Proteomic databases

PaxDbⁱ	Q0DWH1
PRIDEⁱ	Q0DWH1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	Os02t0815500-01; Os02t0815500-01; Os02g0815500
GeneIDⁱ	4331130
Grameneⁱ	Os02t0815500-01; Os02t0815500-01; Os02g0815500
KEGGⁱ	osa:4331130

Phylogenomic databases

eggNOGⁱ	KOG0022 Eukaryota COG1062 LUCA
InParanoidⁱ	Q0DWH1
KEGG Orthology (KO) More...KOⁱ	K00121
OMAⁱ	CIGNVNT
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360BVQ

Enzyme and pathway databases

Reactomeⁱ	R-OSA-2161541 Abacavir metabolism R-OSA-5365859 RA biosynthesis pathway R-OSA-71384 Ethanol oxidation

Reactomeⁱ

R-OSA-2161541 Abacavir metabolism
R-OSA-5365859 RA biosynthesis pathway
R-OSA-71384 Ethanol oxidation

Gene expression databases

ExpressionAtlasⁱ	Q0DWH1 differential
Genevisibleⁱ	Q0DWH1 OS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08300 alcohol_DH_class_III, 1 hit
InterProⁱ	View protein in InterPro IPR014183 ADH_3 IPR013149 ADH_C IPR013154 ADH_N IPR002328 ADH_Zn_CS IPR011032 GroES-like_sf IPR036291 NAD(P)-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08240 ADH_N, 1 hit PF00107 ADH_zinc_N, 1 hit
SUPFAMⁱ	SSF50129 SSF50129, 2 hits SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR02818 adh_III_F_hyde, 1 hit
PROSITEⁱ	View protein in PROSITE PS00059 ADH_ZINC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADHX_ORYSJ
Accessionⁱ	Q0DWH1Primary (citable) accession number: Q0DWH1 Secondary accession number(s): A0A0P0VRA8, P93436, Q6K6C1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
	Last sequence update:	October 17, 2006
	Last modified:	May 23, 2018
	This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q0DWH1 (ADHX_ORYSJ)

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Alcohol dehydrogenase class-3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

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Sequence databases

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Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

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Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ