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UniProtKB - Q0DWH1 (ADHX_ORYSJ)
Protein
Alcohol dehydrogenase class-3
Gene
Os02g0815500
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Catalytic activityi
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 49 | Zinc 1; catalyticBy similarity | 1 | |
Binding sitei | 50 | NADBy similarity | 1 | |
Binding sitei | 51 | SubstrateBy similarity | 1 | |
Metal bindingi | 71 | Zinc 1; catalyticBy similarity | 1 | |
Binding sitei | 71 | SubstrateBy similarity | 1 | |
Metal bindingi | 72 | Zinc 1By similarity | 1 | |
Metal bindingi | 101 | Zinc 2By similarity | 1 | |
Metal bindingi | 104 | Zinc 2By similarity | 1 | |
Metal bindingi | 107 | Zinc 2By similarity | 1 | |
Metal bindingi | 115 | Zinc 2By similarity | 1 | |
Metal bindingi | 179 | Zinc 1; catalyticBy similarity | 1 | |
Binding sitei | 228 | NADBy similarity | 1 | |
Binding sitei | 233 | NADBy similarity | 1 | |
Binding sitei | 274 | NAD; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 374 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 204 – 209 | NADBy similarity | 6 | |
Nucleotide bindingi | 297 – 299 | NADBy similarity | 3 | |
Nucleotide bindingi | 322 – 324 | NADBy similarity | 3 |
GO - Molecular functioni
- alcohol dehydrogenase activity, zinc-dependent Source: GO_Central
- S-(hydroxymethyl)glutathione dehydrogenase activity Source: GO_Central
- S-(hydroxymethyl)glutathione dehydrogenase NAD activity Source: UniProtKB-EC
- S-(hydroxymethyl)glutathione dehydrogenase NADP activity Source: UniProtKB-EC
- S-nitrosoglutathione reductase activity Source: EnsemblPlants
- zinc ion binding Source: GO_Central
GO - Biological processi
- cell death Source: EnsemblPlants
- ethanol oxidation Source: InterPro
- formaldehyde catabolic process Source: GO_Central
- heat acclimation Source: EnsemblPlants
- seed development Source: EnsemblPlants
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Enzyme and pathway databases
PlantReactomei | R-OSA-1119267, Phenylalanine degradation III |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Ordered Locus Names:Os02g0815500, LOC_Os02g57040 ORF Names:OsJ_008550, P0643F09.4 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160773 | 1 – 381 | Alcohol dehydrogenase class-3Add BLAST | 381 |
Proteomic databases
PaxDbi | Q0DWH1 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 4530.OS02T0815500-01 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0022, Eukaryota |
HOGENOMi | CLU_026673_14_0_1 |
InParanoidi | Q0DWH1 |
OMAi | CIRCVVN |
OrthoDBi | 664798at2759 |
Family and domain databases
CDDi | cd08300, alcohol_DH_class_III, 1 hit |
InterProi | View protein in InterPro IPR014183, ADH_3 IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 2 hits SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR02818, adh_III_F_hyde, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0DWH1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSTQGQVI TCKAAVAWEA NRPMTIEDVQ VAPPQAGEVR VKILFTALCH
60 70 80 90 100
TDHYTWSGKD PEGLFPCILG HEAAGIVESV GEGVTEVQPG DHVIPCYQAE
110 120 130 140 150
CRECKFCKSG KTNLCGKVRA ATGVGVMMND RKSRFSINGK PIYHFMGTST
160 170 180 190 200
FSQYTVVHDV SVAKINPQAP LDKVCLLGCG VSTGLGAVWN TAKVEAGSIV
210 220 230 240 250
AIFGLGTVGL AVAEGAKSAG ASRIIGIDID SKKFDVAKNF GVTEFVNPKD
260 270 280 290 300
HDKPIQQVIV DLTDGGVDYS FECIGNVSVM RSALECCHKG WGTSVIVGVA
310 320 330 340 350
ASGQEISTRP FQLVTGRVWK GTAFGGFKSR SQVPWLVEKY LNKEIKVDEY
360 370 380
VTHSMNLTDI NKAFDLLHEG GCLRCVLATD K
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 318 | V → I in AK099733 (PubMed:12869764).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP004120 Genomic DNA Translation: BAD21676.1 AP005111 Genomic DNA Translation: BAD21999.1 AP008208 Genomic DNA Translation: BAF10417.1 AP014958 Genomic DNA Translation: BAS81559.1 CM000139 Genomic DNA Translation: EAZ25067.1 AK099733 mRNA No translation available. |
RefSeqi | XP_015627169.1, XM_015771683.1 |
Genome annotation databases
EnsemblPlantsi | Os02t0815500-01; Os02t0815500-01; Os02g0815500 |
GeneIDi | 4331130 |
Gramenei | Os02t0815500-01; Os02t0815500-01; Os02g0815500 |
KEGGi | osa:4331130 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP004120 Genomic DNA Translation: BAD21676.1 AP005111 Genomic DNA Translation: BAD21999.1 AP008208 Genomic DNA Translation: BAF10417.1 AP014958 Genomic DNA Translation: BAS81559.1 CM000139 Genomic DNA Translation: EAZ25067.1 AK099733 mRNA No translation available. |
RefSeqi | XP_015627169.1, XM_015771683.1 |
3D structure databases
SMRi | Q0DWH1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS02T0815500-01 |
Proteomic databases
PaxDbi | Q0DWH1 |
Genome annotation databases
EnsemblPlantsi | Os02t0815500-01; Os02t0815500-01; Os02g0815500 |
GeneIDi | 4331130 |
Gramenei | Os02t0815500-01; Os02t0815500-01; Os02g0815500 |
KEGGi | osa:4331130 |
Phylogenomic databases
eggNOGi | KOG0022, Eukaryota |
HOGENOMi | CLU_026673_14_0_1 |
InParanoidi | Q0DWH1 |
OMAi | CIRCVVN |
OrthoDBi | 664798at2759 |
Enzyme and pathway databases
PlantReactomei | R-OSA-1119267, Phenylalanine degradation III |
Gene expression databases
Genevisiblei | Q0DWH1, OS |
Family and domain databases
CDDi | cd08300, alcohol_DH_class_III, 1 hit |
InterProi | View protein in InterPro IPR014183, ADH_3 IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 2 hits SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR02818, adh_III_F_hyde, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADHX_ORYSJ | |
Accessioni | Q0DWH1Primary (citable) accession number: Q0DWH1 Secondary accession number(s): A0A0P0VRA8, P93436, Q6K6C1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 12, 2007 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 23, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - SIMILARITY comments
Index of protein domains and families