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Protein

Alcohol dehydrogenase class-3

Gene

Os02g0815500

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49Zinc 1; catalyticBy similarity1
Binding sitei50NADBy similarity1
Binding sitei51SubstrateBy similarity1
Metal bindingi71Zinc 1; catalyticBy similarity1
Binding sitei71SubstrateBy similarity1
Metal bindingi72Zinc 1By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi179Zinc 1; catalyticBy similarity1
Binding sitei228NADBy similarity1
Binding sitei233NADBy similarity1
Binding sitei274NAD; via carbonyl oxygenBy similarity1
Binding sitei374NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 209NADBy similarity6
Nucleotide bindingi297 – 299NADBy similarity3
Nucleotide bindingi322 – 324NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-OSA-2161541 Abacavir metabolism
R-OSA-5365859 RA biosynthesis pathway
R-OSA-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 (EC:1.1.1.1By similarity)
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284By similarity)
Gene namesi
Ordered Locus Names:Os02g0815500, LOC_Os02g57040
ORF Names:OsJ_008550, P0643F09.4
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607731 – 381Alcohol dehydrogenase class-3Add BLAST381

Proteomic databases

PaxDbiQ0DWH1
PRIDEiQ0DWH1

Expressioni

Gene expression databases

ExpressionAtlasiQ0DWH1 differential
GenevisibleiQ0DWH1 OS

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os02g57040.1

Structurei

3D structure databases

ProteinModelPortaliQ0DWH1
SMRiQ0DWH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
InParanoidiQ0DWH1
KOiK00121
OMAiCIGNVNT
OrthoDBiEOG09360BVQ

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q0DWH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTQGQVI TCKAAVAWEA NRPMTIEDVQ VAPPQAGEVR VKILFTALCH
60 70 80 90 100
TDHYTWSGKD PEGLFPCILG HEAAGIVESV GEGVTEVQPG DHVIPCYQAE
110 120 130 140 150
CRECKFCKSG KTNLCGKVRA ATGVGVMMND RKSRFSINGK PIYHFMGTST
160 170 180 190 200
FSQYTVVHDV SVAKINPQAP LDKVCLLGCG VSTGLGAVWN TAKVEAGSIV
210 220 230 240 250
AIFGLGTVGL AVAEGAKSAG ASRIIGIDID SKKFDVAKNF GVTEFVNPKD
260 270 280 290 300
HDKPIQQVIV DLTDGGVDYS FECIGNVSVM RSALECCHKG WGTSVIVGVA
310 320 330 340 350
ASGQEISTRP FQLVTGRVWK GTAFGGFKSR SQVPWLVEKY LNKEIKVDEY
360 370 380
VTHSMNLTDI NKAFDLLHEG GCLRCVLATD K
Length:381
Mass (Da):40,823
Last modified:October 17, 2006 - v1
Checksum:iC107E6B8B2CB7F58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti318V → I in AK099733 (PubMed:12869764).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004120 Genomic DNA Translation: BAD21676.1
AP005111 Genomic DNA Translation: BAD21999.1
AP008208 Genomic DNA Translation: BAF10417.1
AP014958 Genomic DNA Translation: BAS81559.1
CM000139 Genomic DNA Translation: EAZ25067.1
AK099733 mRNA No translation available.
RefSeqiXP_015627169.1, XM_015771683.1
UniGeneiOs.59290

Genome annotation databases

EnsemblPlantsiOs02t0815500-01; Os02t0815500-01; Os02g0815500
GeneIDi4331130
GrameneiOs02t0815500-01; Os02t0815500-01; Os02g0815500
KEGGiosa:4331130

Similar proteinsi

Entry informationi

Entry nameiADHX_ORYSJ
AccessioniPrimary (citable) accession number: Q0DWH1
Secondary accession number(s): A0A0P0VRA8, P93436, Q6K6C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

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