UniProtKB - Q0DC43 (Q0DC43_ORYSJ)
Protein
Formate dehydrogenase, mitochondrial
Gene
N/A
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Catalyzes the NAD+-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
- EC:1.17.1.9UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 120 | Substrate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 144 | SubstrateUniRule annotation | 1 | |
Binding sitei | 145 | NADUniRule annotation | 1 | |
Binding sitei | 219 | NADUniRule annotation | 1 | |
Binding sitei | 280 | NAD; via carbonyl oxygenUniRule annotation | 1 | |
Sitei | 282 | Important for catalytic activityUniRule annotation | 1 | |
Binding sitei | 306 | NADUniRule annotation | 1 | |
Sitei | 330 | Important for catalytic activityUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 199 – 200 | NADUniRule annotation | 2 | |
Nucleotide bindingi | 254 – 258 | NADUniRule annotation | 5 | |
Nucleotide bindingi | 330 – 333 | NADUniRule annotation | 4 |
GO - Molecular functioni
- formate dehydrogenase (NAD+) activity Source: UniProtKB-UniRule
- NAD binding Source: InterPro
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
GO - Biological processi
- formate catabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Ligand | NADUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Formate dehydrogenase, mitochondrialUniRule annotation (EC:1.17.1.9UniRule annotation)Short name: FDHUniRule annotation Alternative name(s): NAD-dependent formate dehydrogenaseUniRule annotation |
Organismi | Oryza sativa subsp. japonica (Rice)Imported |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Subcellular locationi
Mitochondrion
- Mitochondrion UniRule annotation
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Other locations
- formate dehydrogenase complex Source: UniProtKB-EC
Keywords - Cellular componenti
MitochondrionUniRule annotationInteractioni
Subunit structurei
Homodimer.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 358 | 2-Hacid_dhInterPro annotationAdd BLAST | 298 | |
Domaini | 154 – 332 | 2-Hacid_dh_CInterPro annotationAdd BLAST | 179 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 145 – 331 | Coenzyme-bindingUniRule annotationAdd BLAST | 187 |
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_019796_0_0_1 |
OMAi | EVTYCNS |
OrthoDBi | 700058at2759 |
Family and domain databases
CDDi | cd05302, FDH, 1 hit |
HAMAPi | MF_03210, Formate_dehydrogenase, 1 hit |
InterProi | View protein in InterPro IPR006139, D-isomer_2_OHA_DH_cat_dom IPR029753, D-isomer_DH_CS IPR029752, D-isomer_DH_CS1 IPR006140, D-isomer_DH_NAD-bd IPR033689, FDH_NAD-dep IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389, 2-Hacid_dh, 1 hit PF02826, 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065, D_2_HYDROXYACID_DH_1, 1 hit PS00670, D_2_HYDROXYACID_DH_2, 1 hit PS00671, D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0DC43-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMWRAAAGH LLGRALGSRA AHTSAGSKKI VGVFYKGGEY ADKNPNFVGC
60 70 80 90 100
VEGALGIREW LESKGHHYIV TDDKEGLNSE LEKHIEDMHV LITTPFHPAY
110 120 130 140 150
VSAERIKKAK NLELLLTAGI GSDHIDLPAA AAAGLTVAEV TGSNTVSVAE
160 170 180 190 200
DELMRILILL RNFLPGYQQV VHGEWNVAGI AYRAYDLEGK TVGTVGAGRI
210 220 230 240 250
GRLLLQRLKP FNCNLLYHDR LKIDPELEKE IGAKYEEDLD AMLPKCDVIV
260 270 280 290 300
INTPLTEKTR GMFNKERIAK MKKGVIIVNN ARGAIMDTQA VADACSSGQV
310 320 330 340 350
AGYGGDVWFP QPAPKDHPWR YMPNHAMTPH ISGTTIDAQL RYAAGVKDML
360 370
DRYFKGEDFP VQNYIVKEGQ LASQYQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JN944369 mRNA Translation: AFI71280.1 AK065872 mRNA Translation: BAG89715.1 |
RefSeqi | XP_015643973.1, XM_015788487.1 |
Genome annotation databases
EnsemblPlantsi | Os06t0486800-01; Os06t0486800-01; Os06g0486800 |
GeneIDi | 4341069 |
Gramenei | Os06t0486800-01; Os06t0486800-01; Os06g0486800 |
KEGGi | osa:4341069 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JN944369 mRNA Translation: AFI71280.1 AK065872 mRNA Translation: BAG89715.1 |
RefSeqi | XP_015643973.1, XM_015788487.1 |
3D structure databases
SMRi | Q0DC43 |
ModBasei | Search... |
Genome annotation databases
EnsemblPlantsi | Os06t0486800-01; Os06t0486800-01; Os06g0486800 |
GeneIDi | 4341069 |
Gramenei | Os06t0486800-01; Os06t0486800-01; Os06g0486800 |
KEGGi | osa:4341069 |
Phylogenomic databases
HOGENOMi | CLU_019796_0_0_1 |
OMAi | EVTYCNS |
OrthoDBi | 700058at2759 |
Gene expression databases
ExpressionAtlasi | Q0DC43, baseline and differential |
Family and domain databases
CDDi | cd05302, FDH, 1 hit |
HAMAPi | MF_03210, Formate_dehydrogenase, 1 hit |
InterProi | View protein in InterPro IPR006139, D-isomer_2_OHA_DH_cat_dom IPR029753, D-isomer_DH_CS IPR029752, D-isomer_DH_CS1 IPR006140, D-isomer_DH_NAD-bd IPR033689, FDH_NAD-dep IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389, 2-Hacid_dh, 1 hit PF02826, 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065, D_2_HYDROXYACID_DH_1, 1 hit PS00670, D_2_HYDROXYACID_DH_2, 1 hit PS00671, D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q0DC43_ORYSJ | |
Accessioni | Q0DC43Primary (citable) accession number: Q0DC43 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 17, 2006 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |