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Protein

Agmatinase, mitochondrial

Gene

Agmat

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

May have little or no activity due to the lack of several residues essential for manganese binding and catalytic activity.Curated

Catalytic activityi

Agmatine + H2O = putrescine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotation

Pathwayi: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatinase, mitochondrial (Agmat)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi163Manganese 1PROSITE-ProRule annotation1
Metal bindingi188Manganese 2PROSITE-ProRule annotation1
Metal bindingi279Manganese 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPutrescine biosynthesis, Spermidine biosynthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-351143 Agmatine biosynthesis
UniPathwayiUPA00534; UER00287

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase, mitochondrial (EC:3.5.3.11By similarity)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:Agmat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1308424 Agmat

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionSequence analysisAdd BLAST33
ChainiPRO_000032007334 – 353Agmatinase, mitochondrialAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194N6-acetyllysineBy similarity1
Modified residuei218N6-acetyllysine; alternateBy similarity1
Modified residuei218N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ0D2L3
PRIDEiQ0D2L3

PTM databases

iPTMnetiQ0D2L3
PhosphoSitePlusiQ0D2L3

Expressioni

Gene expression databases

BgeeiENSRNOG00000012315
GenevisibleiQ0D2L3 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016646

Structurei

3D structure databases

ProteinModelPortaliQ0D2L3
SMRiQ0D2L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2964 Eukaryota
COG0010 LUCA
GeneTreeiENSGT00530000063082
HOGENOMiHOG000204320
HOVERGENiHBG023165
InParanoidiQ0D2L3
KOiK01480
OMAiDTYFGAE
OrthoDBiEOG091G0HCM
PhylomeDBiQ0D2L3
TreeFamiTF328612

Family and domain databases

InterProiView protein in InterPro
IPR005925 Agmatinase-rel
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01230 agmatinase, 1 hit
PROSITEiView protein in PROSITE
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0D2L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQLLKSSWV RSAGSGVVTW RASAGLFCPG TRQASDTSDT LHHPSPSSES
60 70 80 90 100
QVQPVRVCSM MHLPLQSSPE GLDAAFVGVP LDTGTSNRPG ARFGPRRIRE
110 120 130 140 150
ESLMLGTVNP STGALPFQSL RVADLGNVNV NLYNLQDSCR LIREAYQNIL
160 170 180 190 200
ATGCIPLTLG GDHTITYPIL QAVAKEHGPV GLVHVGAHSN TSDKPLEDKV
210 220 230 240 250
YHRTPFRRSV DEGLLDSKRV VQIGIRGSSR TLDPYRYSRS QGFRVVLAED
260 270 280 290 300
CWMKSLVPLM AEIRQQMGGV PLYISFAIDA LDPAYAPGTG TPEIAGLTPS
310 320 330 340 350
QALEIIRGCQ GLNVVGCDLV EVSPPYDLSG NTALLAANLL FEMLCALPKV

TTV
Length:353
Mass (Da):37,987
Last modified:October 17, 2006 - v1
Checksum:iE59BC1FECE84735A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091231 mRNA Translation: AAH91231.1
BC105628 mRNA Translation: AAI05629.1
RefSeqiNP_001041650.1, NM_001048185.1
UniGeneiRn.7880

Genome annotation databases

EnsembliENSRNOT00000016648; ENSRNOP00000016646; ENSRNOG00000012315
GeneIDi298607
KEGGirno:298607
UCSCiRGD:1308424 rat

Similar proteinsi

Entry informationi

Entry nameiSPEB_RAT
AccessioniPrimary (citable) accession number: Q0D2L3
Secondary accession number(s): Q5BK25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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