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Protein

Protein ripply1

Gene

RIPPLY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ripply1
Gene namesi
Name:RIPPLY1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147223.5
HGNCiHGNC:25117 RIPPLY1
MIMi300575 gene
neXtProtiNX_Q0D2K3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi92129
OpenTargetsiENSG00000147223
PharmGKBiPA162401348

Polymorphism and mutation databases

BioMutaiRIPPLY1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077561 – 151Protein ripply1Add BLAST151

Proteomic databases

PaxDbiQ0D2K3
PRIDEiQ0D2K3
ProteomicsDBi58746
58747 [Q0D2K3-2]

PTM databases

PhosphoSitePlusiQ0D2K3

Expressioni

Gene expression databases

BgeeiENSG00000147223
CleanExiHS_RIPPLY1
GenevisibleiQ0D2K3 HS

Organism-specific databases

HPAiHPA052284

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124912, 12 interactors
IntActiQ0D2K3, 39 interactors
STRINGi9606.ENSP00000276173

Structurei

3D structure databases

ProteinModelPortaliQ0D2K3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 131Ripply homology domainSequence analysisAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi57 – 60WRPW motifSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 10Poly-AlaSequence analysis7
Compositional biasi137 – 150Poly-GluSequence analysisAdd BLAST14

Domaini

The ripply homology domain is required for transcriptional repression.By similarity
The WRPW motif is required for binding to TLE/GROUCHO proteins.By similarity

Sequence similaritiesi

Belongs to the ripply family.Curated

Phylogenomic databases

eggNOGiENOG410J6ZC Eukaryota
ENOG4112884 LUCA
GeneTreeiENSGT00390000008909
HOGENOMiHOG000154131
HOVERGENiHBG098215
InParanoidiQ0D2K3
OMAiFWPKSRS
OrthoDBiEOG091G0SRT
PhylomeDBiQ0D2K3
TreeFamiTF336045

Family and domain databases

InterProiView protein in InterPro
IPR028127 Ripply_fam
PANTHERiPTHR16770 PTHR16770, 1 hit
PfamiView protein in Pfam
PF14998 Ripply, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q0D2K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSAACAAAA TPVPALALAL APDLAQAPLA LPGLLSPSCL LSSGQEVNGS
60 70 80 90 100
ERGTCLWRPW LSSTNDSPRQ MRKLVDLAAG GATAAEVTKA ESKFHHPVRL
110 120 130 140 150
FWPKSRSFDY LYSAGEILLQ NFPVQATINL YEDSDSEEEE EDEEQEDEEE

K
Note: No experimental confirmation available.Curated
Length:151
Mass (Da):16,379
Last modified:October 17, 2006 - v1
Checksum:i201C7BA5C5C8025F
GO
Isoform 22 Publications (identifier: Q0D2K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-99: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:104
Mass (Da):11,219
Checksum:iCFDC92C64319535F
GO

Sequence cautioni

The sequence AAI10437 differs from that shown. Intron retention.Curated
The sequence CAI40159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI40160 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05255553 – 99Missing in isoform 2. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591849 Genomic DNA Translation: CAI40159.1 Different initiation.
AL591849 Genomic DNA Translation: CAI40160.1 Different initiation.
CH471120 Genomic DNA Translation: EAX02733.1
BC105691 mRNA Translation: AAI05692.1
BC105692 mRNA Translation: AAI05693.1
BC110436 mRNA Translation: AAI10437.1 Sequence problems.
BC127250 mRNA Translation: AAI27251.1
CCDSiCCDS48145.1 [Q0D2K3-1]
CCDS55471.1 [Q0D2K3-2]
RefSeqiNP_001165177.1, NM_001171706.1 [Q0D2K3-2]
NP_612391.1, NM_138382.2 [Q0D2K3-1]
UniGeneiHs.334726

Genome annotation databases

EnsembliENST00000276173; ENSP00000276173; ENSG00000147223 [Q0D2K3-1]
ENST00000411805; ENSP00000400539; ENSG00000147223 [Q0D2K3-2]
GeneIDi92129
KEGGihsa:92129
UCSCiuc004emr.3 human [Q0D2K3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRIPP1_HUMAN
AccessioniPrimary (citable) accession number: Q0D2K3
Secondary accession number(s): A0JP63
, Q0VGB3, Q5JRB8, Q5JRB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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