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Entry version 108 (02 Jun 2021)
Sequence version 1 (17 Oct 2006)
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Protein

Protein ripply1

Gene

RIPPLY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q0D2K3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ripply1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIPPLY1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25117, RIPPLY1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300575, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q0D2K3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000147223.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
92129

Open Targets

More...
OpenTargetsi
ENSG00000147223

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162401348

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q0D2K3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RIPPLY1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003077561 – 151Protein ripply1Add BLAST151

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q0D2K3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0D2K3

PeptideAtlas

More...
PeptideAtlasi
Q0D2K3

PRoteomics IDEntifications database

More...
PRIDEi
Q0D2K3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58746 [Q0D2K3-1]
58747 [Q0D2K3-2]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0D2K3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147223, Expressed in right lobe of liver and 67 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0D2K3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000147223, Tissue enhanced (kidney, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q0D2K3
With#Exp.IntAct
AVPI1 [Q5T686]3EBI-10226430,EBI-8640233
BEND7 - isoform 2 [Q8N7W2-2]3EBI-10226430,EBI-10181188
CFAP58 [Q5T655]3EBI-10226430,EBI-10245749
CTNNA3 - isoform 2 [Q9UI47-2]3EBI-10226430,EBI-11962928
DCAF15 [Q66K64]3EBI-10226430,EBI-2559052
DIRAS2 [Q96HU8]3EBI-10226430,EBI-911391
FHL2 [Q14192]3EBI-10226430,EBI-701903
GRAPL [Q8TC17]3EBI-10226430,EBI-18300553
GRHL3 - isoform 2 [Q8TE85-2]3EBI-10226430,EBI-12827521
H3-4 [Q16695]3EBI-10226430,EBI-358900
HAND2 - isoform 2 [P61296-2]3EBI-10226430,EBI-13086076
HDAC7 - isoform 5 [Q8WUI4-5]3EBI-10226430,EBI-10276431
HDAC7 - isoform 6 [Q8WUI4-6]6EBI-10226430,EBI-12094670
IRAK1BP1 [Q5VVH5]3EBI-10226430,EBI-9658404
KRT34 [O76011]3EBI-10226430,EBI-1047093
MCCD1 [P59942]3EBI-10226430,EBI-11987923
MDFI [Q99750]6EBI-10226430,EBI-724076
MED19 - isoform 2 [A0JLT2-2]3EBI-10226430,EBI-13288755
MEOX2 [Q6FHY5]3EBI-10226430,EBI-16439278
NDUFB7 [P17568]3EBI-10226430,EBI-1246238
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-10226430,EBI-11022007
PBX4 [Q9BYU1]3EBI-10226430,EBI-10302990
PFDN5 [Q99471]3EBI-10226430,EBI-357275
PLAGL2 [Q9UPG8]5EBI-10226430,EBI-2876622
PRR20D [P86480]3EBI-10226430,EBI-12754095
PTTG2 - isoform 2 [Q9NZH5-2]3EBI-10226430,EBI-17630019
RBPMS [Q93062]3EBI-10226430,EBI-740322
REL [Q04864]3EBI-10226430,EBI-307352
RHOH [Q15669]3EBI-10226430,EBI-1244971
SAPCD1 - isoform 2 [Q5SSQ6-2]3EBI-10226430,EBI-13072754
THAP1 [Q9NVV9]6EBI-10226430,EBI-741515
TLE5 - isoform 2 [Q08117-2]3EBI-10226430,EBI-11741437
TRAF1 [Q13077]3EBI-10226430,EBI-359224
TRAF2 [Q12933]6EBI-10226430,EBI-355744
TRAF3 [Q13114]3EBI-10226430,EBI-357631
VAC14 [Q08AM6]3EBI-10226430,EBI-2107455
VGLL1 [Q99990]3EBI-10226430,EBI-11983165
ZMYND12 [Q9H0C1]3EBI-10226430,EBI-12030590
ZNF620 [Q6ZNG0]3EBI-10226430,EBI-4395669
ZNF784 [Q8NCA9]3EBI-10226430,EBI-7138303

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124912, 50 interactors

Protein interaction database and analysis system

More...
IntActi
Q0D2K3, 44 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000276173

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q0D2K3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni96 – 131Ripply homology domainSequence analysisAdd BLAST36
Regioni130 – 151DisorderedSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi57 – 60WRPW motifSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi132 – 151Acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ripply homology domain is required for transcriptional repression.By similarity
The WRPW motif is required for binding to TLE/GROUCHO proteins.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ripply family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S6U6, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161952

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_117697_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0D2K3

Identification of Orthologs from Complete Genome Data

More...
OMAi
ADSEFHH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0D2K3

TreeFam database of animal gene trees

More...
TreeFami
TF336045

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028127, Ripply_fam

The PANTHER Classification System

More...
PANTHERi
PTHR16770, PTHR16770, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14998, Ripply, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 12 Publications (identifier: Q0D2K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSAACAAAA TPVPALALAL APDLAQAPLA LPGLLSPSCL LSSGQEVNGS
60 70 80 90 100
ERGTCLWRPW LSSTNDSPRQ MRKLVDLAAG GATAAEVTKA ESKFHHPVRL
110 120 130 140 150
FWPKSRSFDY LYSAGEILLQ NFPVQATINL YEDSDSEEEE EDEEQEDEEE

K
Length:151
Mass (Da):16,379
Last modified:October 17, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i201C7BA5C5C8025F
GO
Isoform 22 Publications (identifier: Q0D2K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-99: Missing.

Show »
Length:104
Mass (Da):11,219
Checksum:iCFDC92C64319535F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI10437 differs from that shown. Intron retention.Curated
The sequence CAI40159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI40160 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05255553 – 99Missing in isoform 2. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL591849 Genomic DNA Translation: CAI40159.1 Different initiation.
AL591849 Genomic DNA Translation: CAI40160.1 Different initiation.
CH471120 Genomic DNA Translation: EAX02733.1
BC105691 mRNA Translation: AAI05692.1
BC105692 mRNA Translation: AAI05693.1
BC110436 mRNA Translation: AAI10437.1 Sequence problems.
BC127250 mRNA Translation: AAI27251.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48145.1 [Q0D2K3-1]
CCDS55471.1 [Q0D2K3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001165177.1, NM_001171706.1 [Q0D2K3-2]
NP_612391.1, NM_138382.2 [Q0D2K3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276173; ENSP00000276173; ENSG00000147223 [Q0D2K3-1]
ENST00000411805; ENSP00000400539; ENSG00000147223 [Q0D2K3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92129

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92129

UCSC genome browser

More...
UCSCi
uc004emr.3, human [Q0D2K3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591849 Genomic DNA Translation: CAI40159.1 Different initiation.
AL591849 Genomic DNA Translation: CAI40160.1 Different initiation.
CH471120 Genomic DNA Translation: EAX02733.1
BC105691 mRNA Translation: AAI05692.1
BC105692 mRNA Translation: AAI05693.1
BC110436 mRNA Translation: AAI10437.1 Sequence problems.
BC127250 mRNA Translation: AAI27251.1
CCDSiCCDS48145.1 [Q0D2K3-1]
CCDS55471.1 [Q0D2K3-2]
RefSeqiNP_001165177.1, NM_001171706.1 [Q0D2K3-2]
NP_612391.1, NM_138382.2 [Q0D2K3-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124912, 50 interactors
IntActiQ0D2K3, 44 interactors
STRINGi9606.ENSP00000276173

PTM databases

PhosphoSitePlusiQ0D2K3

Genetic variation databases

BioMutaiRIPPLY1

Proteomic databases

MassIVEiQ0D2K3
PaxDbiQ0D2K3
PeptideAtlasiQ0D2K3
PRIDEiQ0D2K3
ProteomicsDBi58746 [Q0D2K3-1]
58747 [Q0D2K3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
63924, 12 antibodies

The DNASU plasmid repository

More...
DNASUi
92129

Genome annotation databases

EnsembliENST00000276173; ENSP00000276173; ENSG00000147223 [Q0D2K3-1]
ENST00000411805; ENSP00000400539; ENSG00000147223 [Q0D2K3-2]
GeneIDi92129
KEGGihsa:92129
UCSCiuc004emr.3, human [Q0D2K3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92129
DisGeNETi92129

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RIPPLY1
HGNCiHGNC:25117, RIPPLY1
HPAiENSG00000147223, Tissue enhanced (kidney, liver)
MIMi300575, gene
neXtProtiNX_Q0D2K3
OpenTargetsiENSG00000147223
PharmGKBiPA162401348
VEuPathDBiHostDB:ENSG00000147223.5

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S6U6, Eukaryota
GeneTreeiENSGT00940000161952
HOGENOMiCLU_117697_0_0_1
InParanoidiQ0D2K3
OMAiADSEFHH
PhylomeDBiQ0D2K3
TreeFamiTF336045

Enzyme and pathway databases

PathwayCommonsiQ0D2K3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
92129, 6 hits in 614 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
92129
PharosiQ0D2K3, Tdark

Protein Ontology

More...
PROi
PR:Q0D2K3
RNActiQ0D2K3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147223, Expressed in right lobe of liver and 67 other tissues
GenevisibleiQ0D2K3, HS

Family and domain databases

InterProiView protein in InterPro
IPR028127, Ripply_fam
PANTHERiPTHR16770, PTHR16770, 1 hit
PfamiView protein in Pfam
PF14998, Ripply, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIPP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0D2K3
Secondary accession number(s): A0JP63
, Q0VGB3, Q5JRB8, Q5JRB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 17, 2006
Last modified: June 2, 2021
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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