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Protein

Intermediate filament family orphan 1

Gene

IFFO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate filament family orphan 1
Alternative name(s):
Tumor antigen HOM-TES-103
Gene namesi
Name:IFFO1
Synonyms:IFFO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000010295.19
HGNCiHGNC:24970 IFFO1
MIMi610495 gene
neXtProtiNX_Q0D2I5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament

Pathology & Biotechi

Organism-specific databases

DisGeNETi25900
OpenTargetsiENSG00000010295
PharmGKBiPA164720809

Polymorphism and mutation databases

BioMutaiIFFO1
DMDMi259016254

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003167941 – 559Intermediate filament family orphan 1Add BLAST559

Proteomic databases

PaxDbiQ0D2I5
PeptideAtlasiQ0D2I5
PRIDEiQ0D2I5
ProteomicsDBi58734
58735 [Q0D2I5-2]
58736 [Q0D2I5-3]
58737 [Q0D2I5-4]
58738 [Q0D2I5-5]
58739 [Q0D2I5-6]
58740 [Q0D2I5-7]

PTM databases

iPTMnetiQ0D2I5
PhosphoSitePlusiQ0D2I5

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000010295 Expressed in 217 organ(s), highest expression level in tendon
CleanExiHS_IFFO1
ExpressionAtlasiQ0D2I5 baseline and differential
GenevisibleiQ0D2I5 HS

Organism-specific databases

HPAiHPA069344

Interactioni

Protein-protein interaction databases

BioGridi117407, 31 interactors
IntActiQ0D2I5, 4 interactors
STRINGi9606.ENSP00000349364

Structurei

3D structure databases

ProteinModelPortaliQ0D2I5
SMRiQ0D2I5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 526IF rodPROSITE-ProRule annotationAdd BLAST454

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili85 – 117Sequence analysisAdd BLAST33
Coiled coili237 – 301Sequence analysisAdd BLAST65
Coiled coili455 – 501Sequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi173 – 182Poly-Ser10
Compositional biasi538 – 542Poly-Pro5

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE4D Eukaryota
ENOG410ZMWF LUCA
GeneTreeiENSGT00510000046803
HOGENOMiHOG000049269
HOVERGENiHBG100545
InParanoidiQ0D2I5
PhylomeDBiQ0D2I5
TreeFamiTF331217

Family and domain databases

InterProiView protein in InterPro
IPR039008 IF_rod_dom
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q0D2I5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA
60 70 80 90 100
YSPPGPGPAP PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL
110 120 130 140 150
LEKQLQQALE EGKQGRRGLG RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS
160 170 180 190 200
PSARVLGSPA RSPAGPLAPS AASLSSSSTS TSTTYSSSAR FMPGTIWSFS
210 220 230 240 250
HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA LYNVLAKVKR
260 270 280 290 300
ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE
310 320 330 340 350
LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE
360 370 380 390 400
DMIQMFQVPS MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN
410 420 430 440 450
EEMQRMLNQL REYDFEDDCD SLTWEETEET LLLWEDFSGY AMAAAEAQGE
460 470 480 490 500
QEDSLEKVIK DTESLFKTRE KEYQETIDQI ELELATAKND MNRHLHEYME
510 520 530 540 550
MCSMKRGLDV QMETCRRLIT QSGDRKSPAF TAVPLSDPPP PPSEAEDSDR

DVSSDSSMR
Length:559
Mass (Da):61,979
Last modified:September 22, 2009 - v2
Checksum:i050FCFFB4953CBD8
GO
Isoform 2 (identifier: Q0D2I5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):22,790
Checksum:i85B455C4F759C047
GO
Isoform 3 (identifier: Q0D2I5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-264: WEEEYT → CFYRVK
     265-559: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:264
Mass (Da):28,128
Checksum:i5FC1FFA8036C1478
GO
Isoform 4 (identifier: Q0D2I5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKKL

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):62,348
Checksum:iA23759D144A4F602
GO
Isoform 5 (identifier: Q0D2I5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKKL
     451-451: Q → QQ

Show »
Length:563
Mass (Da):62,476
Checksum:iFD057A78376C2486
GO
Isoform 6 (identifier: Q0D2I5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.
     451-451: Q → QQ

Show »
Length:200
Mass (Da):22,918
Checksum:i9652F97422DFD9B0
GO
Isoform 7 (identifier: Q0D2I5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKL
     451-451: Q → QQ

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):62,348
Checksum:i540FFA923014FCA3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZ16A0A087WZ16_HUMAN
Intermediate filament family orphan...
IFFO1
571Annotation score:
E9PPX7E9PPX7_HUMAN
Intermediate filament family orphan...
IFFO1
255Annotation score:
F8W8H2F8W8H2_HUMAN
Intermediate filament family orphan...
IFFO1
256Annotation score:

Sequence cautioni

The sequence AF124432 differs from that shown. Reason: Frameshift at positions 119, 226 and 384.Curated
The sequence AF124432 differs from that shown. Reason: Frameshift at positions 121, 227 and 385.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152 – 153SA → LE in AF124432 (PubMed:12032826).Curated2
Sequence conflicti285A → V in AF124432 (PubMed:12032826).Curated1
Sequence conflicti358V → F in AAI10388 (PubMed:15489334).Curated1
Sequence conflicti387P → A in AF124432 (PubMed:12032826).Curated1
Sequence conflicti471K → M in AF124432 (PubMed:12032826).Curated1
Sequence conflicti474Q → H in AF124432 (PubMed:12032826).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0307811 – 360Missing in isoform 2 and isoform 6. 1 PublicationAdd BLAST360
Alternative sequenceiVSP_030782259 – 264WEEEYT → CFYRVK in isoform 3. 1 Publication6
Alternative sequenceiVSP_030783265 – 559Missing in isoform 3. 1 PublicationAdd BLAST295
Alternative sequenceiVSP_030784357Q → QKKL in isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_039709357Q → QKL in isoform 7. 1 Publication1
Alternative sequenceiVSP_038240451Q → QQ in isoform 5, isoform 6 and isoform 7. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471116 Genomic DNA Translation: EAW88781.1
CH471116 Genomic DNA Translation: EAW88783.1
BC002857 mRNA Translation: AAH02857.2
BC004384 mRNA Translation: AAH04384.2
BC010431 mRNA No translation available.
BC071170 mRNA Translation: AAH71170.1
BC103817 mRNA Translation: AAI03818.1
BC103818 mRNA Translation: AAI03819.1
BC110387 mRNA Translation: AAI10388.1
BC113848 mRNA Translation: AAI13849.1
BC114454 mRNA Translation: AAI14455.1
AF124432 mRNA No translation available.
CCDSiCCDS41741.1 [Q0D2I5-5]
CCDS81655.1 [Q0D2I5-1]
CCDS8550.2 [Q0D2I5-4]
RefSeqiNP_001034759.1, NM_001039670.2 [Q0D2I5-5]
NP_001317253.1, NM_001330324.1 [Q0D2I5-1]
NP_542768.2, NM_080730.4 [Q0D2I5-4]
XP_006719038.1, XM_006718975.3 [Q0D2I5-7]
UniGeneiHs.15243

Genome annotation databases

EnsembliENST00000336604; ENSP00000337593; ENSG00000010295 [Q0D2I5-4]
ENST00000356896; ENSP00000349364; ENSG00000010295 [Q0D2I5-5]
ENST00000396840; ENSP00000380052; ENSG00000010295 [Q0D2I5-1]
ENST00000487279; ENSP00000432493; ENSG00000010295 [Q0D2I5-3]
GeneIDi25900
KEGGihsa:25900
UCSCiuc001qpc.3 human [Q0D2I5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471116 Genomic DNA Translation: EAW88781.1
CH471116 Genomic DNA Translation: EAW88783.1
BC002857 mRNA Translation: AAH02857.2
BC004384 mRNA Translation: AAH04384.2
BC010431 mRNA No translation available.
BC071170 mRNA Translation: AAH71170.1
BC103817 mRNA Translation: AAI03818.1
BC103818 mRNA Translation: AAI03819.1
BC110387 mRNA Translation: AAI10388.1
BC113848 mRNA Translation: AAI13849.1
BC114454 mRNA Translation: AAI14455.1
AF124432 mRNA No translation available.
CCDSiCCDS41741.1 [Q0D2I5-5]
CCDS81655.1 [Q0D2I5-1]
CCDS8550.2 [Q0D2I5-4]
RefSeqiNP_001034759.1, NM_001039670.2 [Q0D2I5-5]
NP_001317253.1, NM_001330324.1 [Q0D2I5-1]
NP_542768.2, NM_080730.4 [Q0D2I5-4]
XP_006719038.1, XM_006718975.3 [Q0D2I5-7]
UniGeneiHs.15243

3D structure databases

ProteinModelPortaliQ0D2I5
SMRiQ0D2I5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117407, 31 interactors
IntActiQ0D2I5, 4 interactors
STRINGi9606.ENSP00000349364

PTM databases

iPTMnetiQ0D2I5
PhosphoSitePlusiQ0D2I5

Polymorphism and mutation databases

BioMutaiIFFO1
DMDMi259016254

Proteomic databases

PaxDbiQ0D2I5
PeptideAtlasiQ0D2I5
PRIDEiQ0D2I5
ProteomicsDBi58734
58735 [Q0D2I5-2]
58736 [Q0D2I5-3]
58737 [Q0D2I5-4]
58738 [Q0D2I5-5]
58739 [Q0D2I5-6]
58740 [Q0D2I5-7]

Protocols and materials databases

DNASUi25900
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336604; ENSP00000337593; ENSG00000010295 [Q0D2I5-4]
ENST00000356896; ENSP00000349364; ENSG00000010295 [Q0D2I5-5]
ENST00000396840; ENSP00000380052; ENSG00000010295 [Q0D2I5-1]
ENST00000487279; ENSP00000432493; ENSG00000010295 [Q0D2I5-3]
GeneIDi25900
KEGGihsa:25900
UCSCiuc001qpc.3 human [Q0D2I5-1]

Organism-specific databases

CTDi25900
DisGeNETi25900
EuPathDBiHostDB:ENSG00000010295.19
GeneCardsiIFFO1
HGNCiHGNC:24970 IFFO1
HPAiHPA069344
MIMi610495 gene
neXtProtiNX_Q0D2I5
OpenTargetsiENSG00000010295
PharmGKBiPA164720809
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE4D Eukaryota
ENOG410ZMWF LUCA
GeneTreeiENSGT00510000046803
HOGENOMiHOG000049269
HOVERGENiHBG100545
InParanoidiQ0D2I5
PhylomeDBiQ0D2I5
TreeFamiTF331217

Miscellaneous databases

ChiTaRSiIFFO1 human
GenomeRNAii25900
PROiPR:Q0D2I5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000010295 Expressed in 217 organ(s), highest expression level in tendon
CleanExiHS_IFFO1
ExpressionAtlasiQ0D2I5 baseline and differential
GenevisibleiQ0D2I5 HS

Family and domain databases

InterProiView protein in InterPro
IPR039008 IF_rod_dom
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFFO1_HUMAN
AccessioniPrimary (citable) accession number: Q0D2I5
Secondary accession number(s): Q24JT6
, Q7L5J9, Q7Z5X4, Q9BQ46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 22, 2009
Last modified: September 12, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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