UniProtKB - Q0D2I5 (IFFO1_HUMAN)
Protein
Intermediate filament family orphan 1
Gene
IFFO1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Intermediate filament family orphan 1Alternative name(s): Tumor antigen HOM-TES-103 |
Gene namesi | Name:IFFO1 Synonyms:IFFO |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000010295.19 |
HGNCi | HGNC:24970, IFFO1 |
MIMi | 610495, gene |
neXtProti | NX_Q0D2I5 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Keywords - Cellular componenti
Intermediate filamentPathology & Biotechi
Organism-specific databases
DisGeNETi | 25900 |
OpenTargetsi | ENSG00000010295 |
PharmGKBi | PA164720809 |
Miscellaneous databases
Pharosi | Q0D2I5, Tdark |
Polymorphism and mutation databases
BioMutai | IFFO1 |
DMDMi | 259016254 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000316794 | 1 – 559 | Intermediate filament family orphan 1Add BLAST | 559 |
Proteomic databases
MassIVEi | Q0D2I5 |
PaxDbi | Q0D2I5 |
PeptideAtlasi | Q0D2I5 |
PRIDEi | Q0D2I5 |
ProteomicsDBi | 58734 [Q0D2I5-1] 58735 [Q0D2I5-2] 58736 [Q0D2I5-3] 58737 [Q0D2I5-4] 58738 [Q0D2I5-5] 58739 [Q0D2I5-6] 58740 [Q0D2I5-7] |
PTM databases
iPTMneti | Q0D2I5 |
PhosphoSitePlusi | Q0D2I5 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000010295, Expressed in tendon and 230 other tissues |
ExpressionAtlasi | Q0D2I5, baseline and differential |
Genevisiblei | Q0D2I5, HS |
Organism-specific databases
HPAi | ENSG00000010295, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 117407, 33 interactors |
IntActi | Q0D2I5, 17 interactors |
STRINGi | 9606.ENSP00000482285 |
Miscellaneous databases
RNActi | Q0D2I5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q0D2I5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 73 – 526 | IF rodPROSITE-ProRule annotationAdd BLAST | 454 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 85 – 117 | Sequence analysisAdd BLAST | 33 | |
Coiled coili | 237 – 301 | Sequence analysisAdd BLAST | 65 | |
Coiled coili | 455 – 501 | Sequence analysisAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 173 – 182 | Poly-Ser | 10 | |
Compositional biasi | 538 – 542 | Poly-Pro | 5 |
Sequence similaritiesi
Belongs to the intermediate filament family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QRD7, Eukaryota |
GeneTreei | ENSGT00510000046803 |
HOGENOMi | CLU_085236_0_0_1 |
InParanoidi | Q0D2I5 |
OrthoDBi | 792412at2759 |
PhylomeDBi | Q0D2I5 |
TreeFami | TF331217 |
Family and domain databases
Gene3Di | 1.20.5.1160, 2 hits |
InterProi | View protein in InterPro IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS51842, IF_ROD_2, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q0D2I5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA
60 70 80 90 100
YSPPGPGPAP PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL
110 120 130 140 150
LEKQLQQALE EGKQGRRGLG RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS
160 170 180 190 200
PSARVLGSPA RSPAGPLAPS AASLSSSSTS TSTTYSSSAR FMPGTIWSFS
210 220 230 240 250
HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA LYNVLAKVKR
260 270 280 290 300
ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE
310 320 330 340 350
LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE
360 370 380 390 400
DMIQMFQVPS MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN
410 420 430 440 450
EEMQRMLNQL REYDFEDDCD SLTWEETEET LLLWEDFSGY AMAAAEAQGE
460 470 480 490 500
QEDSLEKVIK DTESLFKTRE KEYQETIDQI ELELATAKND MNRHLHEYME
510 520 530 540 550
MCSMKRGLDV QMETCRRLIT QSGDRKSPAF TAVPLSDPPP PPSEAEDSDR
DVSSDSSMR
Isoform 3 (identifier: Q0D2I5-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
259-264: WEEEYT → CFYRVK
265-559: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZ16 | A0A087WZ16_HUMAN | Intermediate filament family orphan... | IFFO1 | 571 | Annotation score: | ||
E9PPX7 | E9PPX7_HUMAN | Intermediate filament family orphan... | IFFO1 | 255 | Annotation score: | ||
F8W8H2 | F8W8H2_HUMAN | Intermediate filament family orphan... | IFFO1 | 256 | Annotation score: |
Sequence cautioni
The sequence AF124432 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 152 – 153 | SA → LE in AF124432 (PubMed:12032826).Curated | 2 | |
Sequence conflicti | 285 | A → V in AF124432 (PubMed:12032826).Curated | 1 | |
Sequence conflicti | 358 | V → F in AAI10388 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 387 | P → A in AF124432 (PubMed:12032826).Curated | 1 | |
Sequence conflicti | 471 | K → M in AF124432 (PubMed:12032826).Curated | 1 | |
Sequence conflicti | 474 | Q → H in AF124432 (PubMed:12032826).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030781 | 1 – 360 | Missing in isoform 2 and isoform 6. 1 PublicationAdd BLAST | 360 | |
Alternative sequenceiVSP_030782 | 259 – 264 | WEEEYT → CFYRVK in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_030783 | 265 – 559 | Missing in isoform 3. 1 PublicationAdd BLAST | 295 | |
Alternative sequenceiVSP_030784 | 357 | Q → QKKL in isoform 4 and isoform 5. 2 Publications | 1 | |
Alternative sequenceiVSP_039709 | 357 | Q → QKL in isoform 7. 1 Publication | 1 | |
Alternative sequenceiVSP_038240 | 451 | Q → QQ in isoform 5, isoform 6 and isoform 7. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471116 Genomic DNA Translation: EAW88781.1 CH471116 Genomic DNA Translation: EAW88783.1 BC002857 mRNA Translation: AAH02857.2 BC004384 mRNA Translation: AAH04384.2 BC010431 mRNA No translation available. BC071170 mRNA Translation: AAH71170.1 BC103817 mRNA Translation: AAI03818.1 BC103818 mRNA Translation: AAI03819.1 BC110387 mRNA Translation: AAI10388.1 BC113848 mRNA Translation: AAI13849.1 BC114454 mRNA Translation: AAI14455.1 AF124432 mRNA No translation available. |
CCDSi | CCDS41741.1 [Q0D2I5-5] CCDS81655.1 [Q0D2I5-1] CCDS8550.2 [Q0D2I5-4] |
RefSeqi | NP_001034759.1, NM_001039670.2 [Q0D2I5-5] NP_001317253.1, NM_001330324.1 [Q0D2I5-1] NP_542768.2, NM_080730.4 [Q0D2I5-4] XP_006719038.1, XM_006718975.3 [Q0D2I5-7] |
Genome annotation databases
Ensembli | ENST00000336604; ENSP00000337593; ENSG00000010295 [Q0D2I5-4] ENST00000356896; ENSP00000349364; ENSG00000010295 [Q0D2I5-5] ENST00000396840; ENSP00000380052; ENSG00000010295 [Q0D2I5-1] ENST00000487279; ENSP00000432493; ENSG00000010295 [Q0D2I5-3] |
GeneIDi | 25900 |
KEGGi | hsa:25900 |
UCSCi | uc001qpc.3, human [Q0D2I5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471116 Genomic DNA Translation: EAW88781.1 CH471116 Genomic DNA Translation: EAW88783.1 BC002857 mRNA Translation: AAH02857.2 BC004384 mRNA Translation: AAH04384.2 BC010431 mRNA No translation available. BC071170 mRNA Translation: AAH71170.1 BC103817 mRNA Translation: AAI03818.1 BC103818 mRNA Translation: AAI03819.1 BC110387 mRNA Translation: AAI10388.1 BC113848 mRNA Translation: AAI13849.1 BC114454 mRNA Translation: AAI14455.1 AF124432 mRNA No translation available. |
CCDSi | CCDS41741.1 [Q0D2I5-5] CCDS81655.1 [Q0D2I5-1] CCDS8550.2 [Q0D2I5-4] |
RefSeqi | NP_001034759.1, NM_001039670.2 [Q0D2I5-5] NP_001317253.1, NM_001330324.1 [Q0D2I5-1] NP_542768.2, NM_080730.4 [Q0D2I5-4] XP_006719038.1, XM_006718975.3 [Q0D2I5-7] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6ABO | X-ray | 2.65 | B | 450-525 | [»] | |
SMRi | Q0D2I5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117407, 33 interactors |
IntActi | Q0D2I5, 17 interactors |
STRINGi | 9606.ENSP00000482285 |
PTM databases
iPTMneti | Q0D2I5 |
PhosphoSitePlusi | Q0D2I5 |
Polymorphism and mutation databases
BioMutai | IFFO1 |
DMDMi | 259016254 |
Proteomic databases
MassIVEi | Q0D2I5 |
PaxDbi | Q0D2I5 |
PeptideAtlasi | Q0D2I5 |
PRIDEi | Q0D2I5 |
ProteomicsDBi | 58734 [Q0D2I5-1] 58735 [Q0D2I5-2] 58736 [Q0D2I5-3] 58737 [Q0D2I5-4] 58738 [Q0D2I5-5] 58739 [Q0D2I5-6] 58740 [Q0D2I5-7] |
Protocols and materials databases
Antibodypediai | 22511, 60 antibodies |
DNASUi | 25900 |
Genome annotation databases
Ensembli | ENST00000336604; ENSP00000337593; ENSG00000010295 [Q0D2I5-4] ENST00000356896; ENSP00000349364; ENSG00000010295 [Q0D2I5-5] ENST00000396840; ENSP00000380052; ENSG00000010295 [Q0D2I5-1] ENST00000487279; ENSP00000432493; ENSG00000010295 [Q0D2I5-3] |
GeneIDi | 25900 |
KEGGi | hsa:25900 |
UCSCi | uc001qpc.3, human [Q0D2I5-1] |
Organism-specific databases
CTDi | 25900 |
DisGeNETi | 25900 |
EuPathDBi | HostDB:ENSG00000010295.19 |
GeneCardsi | IFFO1 |
HGNCi | HGNC:24970, IFFO1 |
HPAi | ENSG00000010295, Low tissue specificity |
MIMi | 610495, gene |
neXtProti | NX_Q0D2I5 |
OpenTargetsi | ENSG00000010295 |
PharmGKBi | PA164720809 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRD7, Eukaryota |
GeneTreei | ENSGT00510000046803 |
HOGENOMi | CLU_085236_0_0_1 |
InParanoidi | Q0D2I5 |
OrthoDBi | 792412at2759 |
PhylomeDBi | Q0D2I5 |
TreeFami | TF331217 |
Enzyme and pathway databases
PathwayCommonsi | Q0D2I5 |
Miscellaneous databases
BioGRID-ORCSi | 25900, 4 hits in 839 CRISPR screens |
ChiTaRSi | IFFO1, human |
GenomeRNAii | 25900 |
Pharosi | Q0D2I5, Tdark |
PROi | PR:Q0D2I5 |
RNActi | Q0D2I5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000010295, Expressed in tendon and 230 other tissues |
ExpressionAtlasi | Q0D2I5, baseline and differential |
Genevisiblei | Q0D2I5, HS |
Family and domain databases
Gene3Di | 1.20.5.1160, 2 hits |
InterProi | View protein in InterPro IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS51842, IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFFO1_HUMAN | |
Accessioni | Q0D2I5Primary (citable) accession number: Q0D2I5 Secondary accession number(s): Q24JT6 Q9BQ46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | September 22, 2009 | |
Last modified: | December 2, 2020 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM