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UniProtKB - Q0CYP4 (M2DH_ASPTN)
Protein
Mannitol 2-dehydrogenase
Gene
ATEG_01190
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Functioni
Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.
By similarityCatalytic activityi
- EC:1.1.1.67
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 37 – 48 | NADBy similarityAdd BLAST | 12 |
GO - Molecular functioni
- mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:ATEG_01190 |
Organismi | Aspergillus terreus (strain NIH 2624 / FGSC A1156) |
Taxonomic identifieri | 341663 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Circumdati › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:ATEG_01190 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000371543 | 1 – 502 | Mannitol 2-dehydrogenaseAdd BLAST | 502 |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 33178.CADATEAP00000339 |
Family & Domainsi
Sequence similaritiesi
Belongs to the mannitol dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QT30, Eukaryota |
HOGENOMi | CLU_027324_0_1_1 |
OMAi | YKPYDNL |
OrthoDBi | 1095102at2759 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR000669, Mannitol_DH IPR013118, Mannitol_DH_C IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
PRINTSi | PR00084, MTLDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0CYP4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPLKLNSRN LAQIFAAGKD RVKVPTYQRG SAVKEGIVHV GVGGFHRAHL
60 70 80 90 100
AVYVDQLMQN HGVNDYAICG VGLQPFDAAM RDALRSQDHL YTVIERSAKG
110 120 130 140 150
SFAHVVGSIN SYLFAPDNRE AVIAKMAHPD THIVSLTITE SGYYYNENTH
160 170 180 190 200
ELQAEHPDIQ FDLDPANEKT PRTTFGFLYA ALARRHQQGL RPFTVLSCDN
210 220 230 240 250
MQKNGSITRH MLESFARLRN PELAKWIAEQ GAFPNAMVDR ITPQTSPTDK
260 270 280 290 300
KALAETIGIE DSWPVVTEPF MQWVLEDQFS DGRPPFEKAG AQVVKNVHDV
310 320 330 340 350
EQFEKHKLRL LNGSHSAIGY AGQMAGFEYV HEVMEHPLYN RFVWQMMQEE
360 370 380 390 400
VKPLLPEIPG VDIDEYCKTL MERFSNPTIM DQLPRICLNA SGKIPQFIMP
410 420 430 440 450
SIAEAIWVTG PFRRLCFVAA AWFRYLNGID DSGKTFNVDD PMREELQAKA
460 470 480 490 500
RAGGTNPAEL LNVKSLFGDD LRSDKRFLQE ITTAMEAIAR DGIMKTMPKY
VD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH476595 Genomic DNA Translation: EAU37947.1 |
RefSeqi | XP_001208555.1, XM_001208555.1 |
Genome annotation databases
EnsemblFungii | EAU37947; EAU37947; ATEG_01190 |
GeneIDi | 4316123 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH476595 Genomic DNA Translation: EAU37947.1 |
RefSeqi | XP_001208555.1, XM_001208555.1 |
3D structure databases
SMRi | Q0CYP4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 33178.CADATEAP00000339 |
Genome annotation databases
EnsemblFungii | EAU37947; EAU37947; ATEG_01190 |
GeneIDi | 4316123 |
Organism-specific databases
VEuPathDBi | FungiDB:ATEG_01190 |
Phylogenomic databases
eggNOGi | ENOG502QT30, Eukaryota |
HOGENOMi | CLU_027324_0_1_1 |
OMAi | YKPYDNL |
OrthoDBi | 1095102at2759 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR000669, Mannitol_DH IPR013118, Mannitol_DH_C IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
PRINTSi | PR00084, MTLDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M2DH_ASPTN | |
Accessioni | Q0CYP4Primary (citable) accession number: Q0CYP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families