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UniProtKB - Q0CW42 (DCL1_ASPTN)

Entry version 77 (07 Apr 2021)
Sequence version 2 (02 Oct 2007)
Previous versions | rss
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Protein

Dicer-like protein 1

Gene

dcl1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1275Magnesium or manganeseBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1368Important for activityBy similarity1
Metal bindingi1373Magnesium or manganeseBy similarity1
Metal bindingi1376Magnesium or manganeseBy similarity1
Metal bindingi1433ZincBy similarity1
Metal bindingi1460Zinc; via tele nitrogenBy similarity1
Metal bindingi1501ZincBy similarity1
Metal bindingi1503ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi129 – 136ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntiviral protein, Helicase, Hydrolase, RNA-binding
Biological processAntiviral defense
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dicer-like protein 1
Including the following 2 domains:
Endoribonuclease dcl1 (EC:3.1.26.-)
ATP-dependent helicase dcl1 (EC:3.6.4.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dcl1
ORF Names:ATEG_02092
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri341663 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Circumdati ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007963 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:ATEG_02092

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003067771 – 1519Dicer-like protein 1Add BLAST1519

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q0CW42

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		33178.CADATEAP00007720

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini116 – 297Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST182
Domaini431 – 601Helicase C-terminalPROSITE-ProRule annotationAdd BLAST171
Domaini634 – 724Dicer dsRNA-binding foldPROSITE-ProRule annotationAdd BLAST91
Domaini1026 – 1184RNase III 1PROSITE-ProRule annotationAdd BLAST159
Domaini1235 – 1387RNase III 2PROSITE-ProRule annotationAdd BLAST153
Domaini1421 – 1489DRBMAdd BLAST69

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi242 – 245DEAH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0701, Eukaryota

Identification of Orthologs from Complete Genome Data

More...OMAi		FNMYVQT

Database of Orthologous Groups

More...OrthoDBi		1337630at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00593, RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1520.10, 2 hits
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038248, Dicer_dimer_sf
IPR005034, Dicer_dimerisation_dom
IPR006935, Helicase/UvrB_N
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000999, RNase_III_dom
IPR036389, RNase_III_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00271, Helicase_C, 1 hit
PF04851, ResIII, 1 hit
PF00636, Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00535, RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit
SSF69065, SSF69065, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51327, DICER_DSRBF, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50142, RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q0CW42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHQNTETAS LATTKGALEP LPPDKTAGLS TGAGHEISSD ESEGSEEETG 
        60         70         80         90        100
LHKDPSQRQR QQNATFQAFL SHHAETIVNS PVKPNQAQSE LSISSLIGRN 
       110        120        130        140        150
ASGTGILNPR EYQIELFERA KVQNTIAVLD TGSGKTLIAV LLLKHVIQTE 
       160        170        180        190        200
LIDRANGNPP RISFFLVDSV TLVYQQASVL RNNLDQNVAH FFGAMGVDLW 
       210        220        230        240        250
NKQTWAEHFE KNMVIVCTAE ILNQCLLNAY ITMQQINLLV FDEAHHTKKD 
       260        270        280        290        300
HPYARIIRDS YLRVPPSSRP RIFGMTASPV DTKGDVLEAA RNLEALLDSK 
       310        320        330        340        350
IATTSKLTIL RQVVNRPNEE VWIYDKLQPT FTSDLYKLME SRFGDISHLE 
       360        370        380        390        400
PMFRFARHAT SELGTWCADR VWVSALADDV LPKVEGSIGG KRQSTGLGQL 
       410        420        430        440        450
PKDVHRDITR IKEASELVES HPPNDPGAPE ALSSKVRVLW KEISQCFGQE 
       460        470        480        490        500
TNTKCIVFTE KRYTAKVLFD LFTVLNVPGL RPGVLIGVRS SDRIGMNVTF 
       510        520        530        540        550
RQQILTMVRF RTGEINCLFA TAVAEEGLDI PDCNLVVRFD LYKTLIQYVQ 
       560        570        580        590        600
SRGRARHADS TYASMIEKDN ADHESILVQV NDAEKIMQSF CQLLPEDRIL 
       610        620        630        640        650
HGNDDDTDAV LDREEWEEPY TLPSTAARLT HHSAITVLAR YASSLQYEND 
       660        670        680        690        700
TSAQVTYVVL PVNDAYVCEV ILPEKSPIRG ATGMPAMKKS TAKRYAAFEA 
       710        720        730        740        750
CRLLRKHRLL DEYLNSVYHR RLPAMRNARL AITSHRTNEY KILPKSSLWN 
       760        770        780        790        800
KQIGVIPGKL YGTVISLKPL TPLAREHGSM ILFTRDRLPQ FPTFPIFLGE 
       810        820        830        840        850
DVETIVLTVP VNMELQPSAD ELDYMTTFTL RIFRDVFRKT YDKEPEKLPY 
       860        870        880        890        900
WLLPAISFPC NQEADPRDVV NWEILSSVHE RDDIEYQADM PPEMLVDRFV 
       910        920        930        940        950
YDHWDGRYRY FTLAVDENLQ PSSPPPSHVA RRRHMDTIMN YSISLSKNSR 
       960        970        980        990       1000
AKFLSRCNWN QPVLHAELVR LRRNLLDRMT DKERKLETRS VICIEPLKIS 
      1010       1020       1030       1040       1050
AIPAAIAATC LAFPAIISRL DAYLIGLEAC KKLGLEISLE YALEALTKDS 
      1060       1070       1080       1090       1100
DNTHEHRSQQ VHMQRGMGKN YERLEFLGDC FLKMATSISL FNQHPDDNEF 
      1110       1120       1130       1140       1150
DYHVNRMCLI CNRNLFNSAV KKELYQFIRS RGFSRDTWYP EGLTLLQGRD 
      1160       1170       1180       1190       1200
HSKKIGSESK HALAEKTIAD VCEALIGAAL LTPGPQHRFD MGVRAVSAVV 
      1210       1220       1230       1240       1250
DSNEHNAASW RDYISLYSIP KYQEQAPDGS EIDLCRRVEE KLGYHFRYPR 
      1260       1270       1280       1290       1300
LLHSAFTHPS YPSAWARVPC YQSLEFLGDA LLDMVCVEDL FRRFPDRDPQ 
      1310       1320       1330       1340       1350
WLTEHKMAMV SNKFLGALAV KLGLHTHLSY FSSALQSQIT HYAEEAQAAA 
      1360       1370       1380       1390       1400
SQSDVAVDYW TLTQDPPKVC LPDMVEAYLG AVFVDSNFRF EEVEVFFQQH 
      1410       1420       1430       1440       1450
IKPYFHDMAI YDTFANRHPT TFLHNKLTNE YGCLNYCLKA GEIPGADGDA 
      1460       1470       1480       1490       1500
STVLAAVIVH DTILTTGVAS SGRYAKVKAS ENALTELLHI DRNEFRKRYQ 
      1510 
CDCVQENGEH GERDVGTPI
Length:1,519
Mass (Da):172,077
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A8FB9F68058DCCF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAU37054 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH476596 Genomic DNA Translation: EAU37054.1 Sequence problems.

NCBI Reference Sequences

More...RefSeqi		XP_001211270.1, XM_001211270.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4316974

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476596 Genomic DNA Translation: EAU37054.1 Sequence problems.
RefSeqiXP_001211270.1, XM_001211270.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi33178.CADATEAP00007720

Proteomic databases

PRIDEiQ0CW42

Genome annotation databases

GeneIDi4316974

Organism-specific databases

VEuPathDBiFungiDB:ATEG_02092

Phylogenomic databases

eggNOGiKOG0701, Eukaryota
OMAiFNMYVQT
OrthoDBi1337630at2759

Family and domain databases

CDDicd00593, RIBOc, 2 hits
Gene3Di1.10.1520.10, 2 hits
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248, Dicer_dimer_sf
IPR005034, Dicer_dimerisation_dom
IPR006935, Helicase/UvrB_N
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000999, RNase_III_dom
IPR036389, RNase_III_sf
PfamiView protein in Pfam
PF00271, Helicase_C, 1 hit
PF04851, ResIII, 1 hit
PF00636, Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00535, RIBOc, 2 hits
SUPFAMiSSF52540, SSF52540, 1 hit
SSF69065, SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327, DICER_DSRBF, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50142, RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCL1_ASPTN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0CW42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 7, 2021
This is version 77 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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