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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei280PROSITE-ProRule annotation1
Active sitei472PROSITE-ProRule annotation1
Active sitei534PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:ATEG_03401
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_03401

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040743918 – 138By similarityAdd BLAST121
ChainiPRO_0000407440139 – 557Carboxypeptidase Y homolog AAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi193 ↔ 433By similarity
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi327 ↔ 341By similarity
Disulfide bondi351 ↔ 374By similarity
Disulfide bondi358 ↔ 367By similarity
Disulfide bondi396 ↔ 403By similarity
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ0CSD3

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00006792

Structurei

3D structure databases

ProteinModelPortaliQ0CSD3
SMRiQ0CSD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000198296
OMAiMDNALPR
OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR008442 Propeptide_carboxypepY
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF05388 Carbpep_Y_N, 1 hit
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CSD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVLPATLLV GAATAAVPPF QQQFQQVLGI PQEEVEQAAP VAPSAPTTPK
60 70 80 90 100
PLQIFQDQLK SLSDEARKLW DEVSNFFPDS MDHNPVFSLP KKHTRRPDSH
110 120 130 140 150
WDHIVRGSDV QGVWVTGADG EKQREVDGKL EAYDLRVKKT DPSALGIDPG
160 170 180 190 200
VKQYTGYLDD NENDKHLFYW FFESRNDPEN DPVVLWLNGG PGCSSLTGLF
210 220 230 240 250
MELGPSSINE KIKPVYNEYS WNSNASVIFL DQPVNVGYSY SGSAVSDTVA
260 270 280 290 300
AGKDVYALLT LFFKQFPEYA KQDFHIAGES YAGHYIPVFA SEILSHKKRN
310 320 330 340 350
INLQSVLIGN GLTDGYTQYE YYRPMGCGEG GYPAVLDKGT CQSMDNALPR
360 370 380 390 400
CQSMIKSCYE SESSWVCIPA SIYCNNALIG PYQRTGQNVY DVRGKCEDES
410 420 430 440 450
NLCYKGMGYV SEYLNKAEVR QAVGAEVDGY DSCNFDINRN FLFHGDWMKP
460 470 480 490 500
YHRLVPGLLE QIPVLIYAGD ADYICNWLGN KAWTEALEWP GQKEYASAEM
510 520 530 540 550
EDLVIEQNAN TGKKIGQVKS HGNFTFMRIY GGGHMVPMDQ PESGLEFFNR

WLGGEWF
Length:557
Mass (Da):62,443
Last modified:October 17, 2006 - v1
Checksum:i5789C84F886F2EB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476597 Genomic DNA Translation: EAU36675.1
RefSeqiXP_001212579.1, XM_001212579.1

Genome annotation databases

EnsemblFungiiEAU36675; EAU36675; ATEG_03401
GeneIDi4317774

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476597 Genomic DNA Translation: EAU36675.1
RefSeqiXP_001212579.1, XM_001212579.1

3D structure databases

ProteinModelPortaliQ0CSD3
SMRiQ0CSD3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi33178.CADATEAP00006792

Protein family/group databases

MEROPSiS10.001

Proteomic databases

PRIDEiQ0CSD3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAU36675; EAU36675; ATEG_03401
GeneIDi4317774

Organism-specific databases

EuPathDBiFungiDB:ATEG_03401

Phylogenomic databases

HOGENOMiHOG000198296
OMAiMDNALPR
OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR008442 Propeptide_carboxypepY
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF05388 Carbpep_Y_N, 1 hit
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBPYA_ASPTN
AccessioniPrimary (citable) accession number: Q0CSD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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