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Protein

Malate dehydrogenase

Gene

mdh

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:HNE_3218
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
Proteomesi
  • UP000001959 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000264761 – 320Malate dehydrogenaseAdd BLAST320

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_3218

Structurei

3D structure databases

ProteinModelPortaliQ0BXA0
SMRiQ0BXA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiQCTPKVE
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q0BXA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARNKIALIG SGMIGGTLAH VAAREELGDV ILFDIAEGLP QGKGLDIAES
60 70 80 90 100
TPVYGASVNL KGVNDYAGIA GADVCIVTAG VPRKPGMSRD DLLGINLKVM
110 120 130 140 150
KAVGEGIKAH APNAFVICIT NPLDAMVWAL QKFSGLPTEK VVGMAGVLDS
160 170 180 190 200
SRFAYFLSEK TGVSVADIHA WTLGGHGDDM VPMVRHSTVG GLPLTQLVAQ
210 220 230 240 250
GWMSQAELDA IVERTRKGGG EIVNLLKTGS AYYAPAESAI AMAKSYLADQ
260 270 280 290 300
KRVLPVASYC SGQYGLKDMY VGVPTLIGAG GAEKIVEFDF NADEKAMFDK
310 320
SVASVNGLIE ACKGIDPSLA
Length:320
Mass (Da):33,388
Last modified:October 17, 2006 - v1
Checksum:i6E76137CC84E83E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA Translation: ABI78288.1
RefSeqiWP_011648189.1, NC_008358.1

Genome annotation databases

EnsemblBacteriaiABI78288; ABI78288; HNE_3218
KEGGihne:HNE_3218

Similar proteinsi

Entry informationi

Entry nameiMDH_HYPNA
AccessioniPrimary (citable) accession number: Q0BXA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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