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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi404 – 411ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Synonyms:valA
Ordered Locus Names:FTH_1609
OrganismiFrancisella tularensis subsp. holarctica (strain OSU18)
Taxonomic identifieri393011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei47 – 67HelicalUniRule annotationAdd BLAST21
Transmembranei88 – 108HelicalUniRule annotationAdd BLAST21
Transmembranei167 – 187HelicalUniRule annotationAdd BLAST21
Transmembranei190 – 210HelicalUniRule annotationAdd BLAST21
Transmembranei279 – 299HelicalUniRule annotationAdd BLAST21
Transmembranei305 – 325HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716261 – 609Lipid A export ATP-binding/permease protein MsbAAdd BLAST609

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ0BKJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 340ABC transmembrane type-1UniRule annotationAdd BLAST295
Domaini372 – 606ABC transporterUniRule annotationAdd BLAST235

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085
OMAiGDLMNRI

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR011917 ABC_transpr_lipidA
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02203 MsbA_lipidA, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51239 MSBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q0BKJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANMIDKIDL KSQGSSNLSG EMTNHQKVGT LYKRLLLQVK HLWHFLLLAA
60 70 80 90 100
IGSIFFSAAD ASMIYLINPI LNYGFGPGGG ITKQSATILM LMGVGMVGLL
110 120 130 140 150
ALRSVGSFVS QYFIGSLGQK VVYKFRKDIY KRLMGLPASF FDKHSTGQII
160 170 180 190 200
SRLLYNVDQV TEATSTAIIT VVQDGTFVIG LIVVMFVSSW QLSLFLIVVG
210 220 230 240 250
PFLGLFISII NKKFRNLSRN TQSSMGNVTH TAEETIRNYK EIRIFGAQQK
260 270 280 290 300
QQNKFFKNLD YTYSQQIRTI ALDALTSPVI QIIASLVLAF SLFTIAIFGT
310 320 330 340 350
NEGDGSSWLT AGSFASFFAA AAAILKPIKN LTKVNVVIQK AVAATEDIFY
360 370 380 390 400
ILDYPAEKET GSKELAKVDG NVTIKDLSFA FGEHKVLSGV SVDIKAGQTV
410 420 430 440 450
AFVGKSGSGK TTLTSIISRF YTQHEGEILL DGVDTRELTL ENLRSHLSIV
460 470 480 490 500
SQNVHLFDDT VYNNIAFGLS REVSEEEVID ALKRANAYEF VQELSDGINT
510 520 530 540 550
NIGNNGSKLS GGQRQRISIA RALLKNAPVL IFDEATSALD NESERVVQQA
560 570 580 590 600
LESLTKSCTT IVIAHRLSTV ENADKIVVMD GGMVVESGKH QELLEQGGLY

TRLYQSGLQ
Length:609
Mass (Da):66,677
Last modified:October 17, 2006 - v1
Checksum:i60CF78514FF19D39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000437 Genomic DNA Translation: ABI83391.1
RefSeqiWP_003017108.1, NC_017463.1

Genome annotation databases

EnsemblBacteriaiABI83391; ABI83391; FTH_1609
KEGGifth:FTH_1609

Similar proteinsi

Entry informationi

Entry nameiMSBA_FRATO
AccessioniPrimary (citable) accession number: Q0BKJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 17, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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